SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hl3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 5hl3 LMO2470 PROTEIN
(Listeria
monocytogenes) 		4 / 6 LEU A 226
LEU A 253
LEU A 221
LEU A 199
 None
 0.93A 1errA-5hl3A:
undetectable		 1errA-5hl3A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 5hl3 LMO2470 PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A 240
LEU A 231
LEU A 246
LEU A 248
LEU A 263
 None
 1.26A 1mx1C-5hl3A:
undetectable		 1mx1C-5hl3A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5hl3 LMO2470 PROTEIN
(Listeria
monocytogenes) 		4 / 5 PHE A 215
LEU A 209
PHE A 193
SER A 165
 None
 1.34A 1wrkB-5hl3A:
undetectable		 1wrkB-5hl3A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5hl3 LMO2470 PROTEIN
(Listeria
monocytogenes) 		4 / 6 LEU A 266
ASN A 233
GLN A 292
ILE A 287
 None
 1.24A 2jn3A-5hl3A:
undetectable		 2jn3A-5hl3A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 5hl3 LMO2470 PROTEIN
(Listeria
monocytogenes) 		5 / 10 MET A  90
ALA A  96
LEU A  75
LEU A  72
LEU A  78
 None
 1.39A 3erdB-5hl3A:
undetectable		 3erdB-5hl3A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5hl3 LMO2470 PROTEIN
(Listeria
monocytogenes) 		3 / 3 THR A 386
ASN A 388
GLU A 362
 None
 0.80A 3v4tA-5hl3A:
undetectable
3v4tC-5hl3A:
undetectable		 3v4tA-5hl3A:
20.79
3v4tC-5hl3A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 5hl3 LMO2470 PROTEIN
(Listeria
monocytogenes) 		4 / 7 TYR A 288
ASP A 272
SER A 291
TYR A 369
 None
 1.15A 4arcA-5hl3A:
undetectable		 4arcA-5hl3A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5hl3 LMO2470 PROTEIN
(Listeria
monocytogenes) 		4 / 8 LEU A 269
VAL A 283
LEU A 231
LEU A 253
 None
 0.96A 4l1xA-5hl3A:
undetectable		 4l1xA-5hl3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5hl3 LMO2470 PROTEIN
(Listeria
monocytogenes) 		3 / 3 ASN A 227
ASP A 203
ASP A 132
 None
None
CA  A 401 (-3.0A)
 0.83A 4obwD-5hl3A:
undetectable		 4obwD-5hl3A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5hl3 LMO2470 PROTEIN
(Listeria
monocytogenes) 		4 / 4 ASP A 103
ILE A 122
PRO A 123
LEU A 125
 None
 1.37A 6mkeB-5hl3A:
undetectable		 6mkeB-5hl3A:
12.77