SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hl4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 5hl4 RING-HYDROXYLATING
DIOXYGENASE
(Sinorhizobium
meliloti) 		4 / 8 PHE A 316
HIS A 204
LEU A 212
HIS A 209
 None
FE  A 502 (-4.0A)
None
FE  A 502 (-3.7A)
 0.96A 1bzmA-5hl4A:
undetectable		 1bzmA-5hl4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_1
(HISTONE
METHYLTRANSFERASE
DOT1L)		 5hl4 RING-HYDROXYLATING
DIOXYGENASE
(Sinorhizobium
meliloti) 		4 / 4 THR A  27
GLN A 368
GLU A 197
ASP A 394
 None
 1.37A 1nw3A-5hl4A:
undetectable		 1nw3A-5hl4A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 5hl4 RING-HYDROXYLATING
DIOXYGENASE
(Sinorhizobium
meliloti) 		3 / 3 TRP A 353
PHE A 316
TRP A 305
 None
 1.43A 1r15C-5hl4A:
undetectable		 1r15C-5hl4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 5hl4 RING-HYDROXYLATING
DIOXYGENASE
(Sinorhizobium
meliloti) 		3 / 3 TRP A 353
PHE A 316
TRP A 305
 None
 1.44A 1r15F-5hl4A:
undetectable		 1r15F-5hl4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 5hl4 RING-HYDROXYLATING
DIOXYGENASE
(Sinorhizobium
meliloti) 		3 / 3 TRP A 353
PHE A 316
TRP A 305
 None
 1.43A 1r15G-5hl4A:
undetectable		 1r15G-5hl4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 5hl4 RING-HYDROXYLATING
DIOXYGENASE
(Sinorhizobium
meliloti) 		3 / 3 TRP A 353
PHE A 316
TRP A 305
 None
 1.43A 1r15H-5hl4A:
undetectable		 1r15H-5hl4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5hl4 RING-HYDROXYLATING
DIOXYGENASE
(Sinorhizobium
meliloti) 		4 / 6 VAL A  72
SER A  74
ARG A  80
LEU A 136
 None
 1.07A 2f8dA-5hl4A:
undetectable		 2f8dA-5hl4A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5hl4 RING-HYDROXYLATING
DIOXYGENASE
(Sinorhizobium
meliloti) 		4 / 8 VAL A 364
TRP A 196
ILE A 186
GLY A 190
 None
 0.95A 2gssA-5hl4A:
undetectable		 2gssA-5hl4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 5hl4 RING-HYDROXYLATING
DIOXYGENASE
(Sinorhizobium
meliloti) 		4 / 7 TYR A  26
TYR A 301
TYR A 381
GLY A 388
 None
 1.27A 2ha4B-5hl4A:
undetectable		 2ha4B-5hl4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 5hl4 RING-HYDROXYLATING
DIOXYGENASE
(Sinorhizobium
meliloti) 		4 / 8 ARG A  14
TYR A 376
VAL A 393
TYR A 396
 None
 1.27A 2y05A-5hl4A:
undetectable
2y05B-5hl4A:
undetectable		 2y05A-5hl4A:
21.86
2y05B-5hl4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 5hl4 RING-HYDROXYLATING
DIOXYGENASE
(Sinorhizobium
meliloti) 		4 / 6 TYR A  32
ALA A  33
LEU A  36
ALA A  66
 None
 0.69A 3b6hA-5hl4A:
undetectable		 3b6hA-5hl4A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 5hl4 RING-HYDROXYLATING
DIOXYGENASE
(Sinorhizobium
meliloti) 		4 / 6 TYR A  32
ALA A  33
LEU A  36
ALA A  66
 None
 0.92A 3b6hB-5hl4A:
undetectable		 3b6hB-5hl4A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5hl4 RING-HYDROXYLATING
DIOXYGENASE
(Sinorhizobium
meliloti) 		5 / 8 VAL A 334
ALA A 280
LEU A 271
THR A 274
LEU A 349
 None
 1.27A 3lfaA-5hl4A:
undetectable		 3lfaA-5hl4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5hl4 RING-HYDROXYLATING
DIOXYGENASE
(Sinorhizobium
meliloti) 		4 / 7 LEU A 349
ASP A 311
THR A 274
ALA A 280
 None
 1.16A 3mbgA-5hl4A:
undetectable
3mbgB-5hl4A:
undetectable		 3mbgA-5hl4A:
15.42
3mbgB-5hl4A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hl4 RING-HYDROXYLATING
DIOXYGENASE
(Sinorhizobium
meliloti) 		5 / 12 SER A 303
LEU A 147
PHE A 308
PHE A 162
ALA A 166
 None
 1.47A 3u9fD-5hl4A:
1.6
3u9fE-5hl4A:
1.7		 3u9fD-5hl4A:
20.14
3u9fE-5hl4A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5hl4 RING-HYDROXYLATING
DIOXYGENASE
(Sinorhizobium
meliloti) 		4 / 6 GLU A 188
THR A 326
THR A  27
ASN A 367
 None
 1.28A 4pfjB-5hl4A:
undetectable		 4pfjB-5hl4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 5hl4 RING-HYDROXYLATING
DIOXYGENASE
(Sinorhizobium
meliloti) 		4 / 7 VAL A  79
GLY A 146
VAL A  50
ARG A  73
 None
 0.81A 5fpdA-5hl4A:
undetectable		 5fpdA-5hl4A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5hl4 RING-HYDROXYLATING
DIOXYGENASE
(Sinorhizobium
meliloti) 		3 / 3 VAL A 318
SER A 303
TRP A 196
 None
 1.05A 5jwaA-5hl4A:
undetectable		 5jwaA-5hl4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5hl4 RING-HYDROXYLATING
DIOXYGENASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A  90
TYR A 113
CYH A  94
LEU A 136
GLY A 135
 None
 1.15A 6bp4B-5hl4A:
undetectable		 6bp4B-5hl4A:
20.79