SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hl6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 5hl6 PUTATIVE GAF SENSOR
PROTEIN
(Burkholderia
vietnamiensis) 		3 / 3 VAL A 119
VAL A  96
TRP A 132
 None
 0.84A 1bdwA-5hl6A:
undetectable
1bdwB-5hl6A:
undetectable		 1bdwA-5hl6A:
13.27
1bdwB-5hl6A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 5hl6 PUTATIVE GAF SENSOR
PROTEIN
(Burkholderia
vietnamiensis) 		3 / 3 ALA A  89
VAL A 119
TRP A 132
 None
 0.81A 1tkqB-5hl6A:
undetectable		 1tkqB-5hl6A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5hl6 PUTATIVE GAF SENSOR
PROTEIN
(Burkholderia
vietnamiensis) 		4 / 5 TRP A 162
ILE A 129
LEU A  33
ALA A 161
 None
 1.30A 1xvaA-5hl6A:
undetectable
1xvaB-5hl6A:
undetectable		 1xvaA-5hl6A:
20.00
1xvaB-5hl6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 5hl6 PUTATIVE GAF SENSOR
PROTEIN
(Burkholderia
vietnamiensis) 		3 / 3 MET A 150
VAL A  96
GLU A 145
 None
 0.90A 3c6gA-5hl6A:
undetectable		 3c6gA-5hl6A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5hl6 PUTATIVE GAF SENSOR
PROTEIN
(Burkholderia
vietnamiensis) 		4 / 5 THR A  87
VAL A  84
GLY A  83
LYS A  82
 None
 1.03A 3elzA-5hl6A:
undetectable		 3elzA-5hl6A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 5hl6 PUTATIVE GAF SENSOR
PROTEIN
(Burkholderia
vietnamiensis) 		5 / 12 LEU A  19
VAL A 134
TYR A  45
LEU A  48
TYR A  16
 None
 1.37A 3medA-5hl6A:
undetectable
3medB-5hl6A:
undetectable		 3medA-5hl6A:
15.21
3medB-5hl6A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SDR_A_210A822_1
(ALPHA-BISABOLENE
SYNTHASE)		 5hl6 PUTATIVE GAF SENSOR
PROTEIN
(Burkholderia
vietnamiensis) 		4 / 4 ASP A 146
ASP A 143
ARG A  50
ASP A  49
 None
 1.32A 3sdrA-5hl6A:
1.1		 3sdrA-5hl6A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SDV_A_911A822_0
(ALPHA-BISABOLENE
SYNTHASE)		 5hl6 PUTATIVE GAF SENSOR
PROTEIN
(Burkholderia
vietnamiensis) 		4 / 4 ASP A 146
ASP A 143
ARG A  50
ASP A  49
 None
 1.36A 3sdvA-5hl6A:
1.0		 3sdvA-5hl6A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5hl6 PUTATIVE GAF SENSOR
PROTEIN
(Burkholderia
vietnamiensis) 		5 / 12 GLY A  86
GLY A  81
ILE A 107
VAL A 131
LEU A  64
 None
 1.04A 4gc9A-5hl6A:
undetectable		 4gc9A-5hl6A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 5hl6 PUTATIVE GAF SENSOR
PROTEIN
(Burkholderia
vietnamiensis) 		5 / 11 ALA A 112
VAL A  66
GLY A  71
PHE A  69
GLY A  55
 None
 1.24A 4xp4A-5hl6A:
undetectable		 4xp4A-5hl6A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5hl6 PUTATIVE GAF SENSOR
PROTEIN
(Burkholderia
vietnamiensis) 		5 / 12 LEU A  19
VAL A 134
TYR A  45
LEU A  48
TYR A  16
 None
 1.25A 5cymA-5hl6A:
undetectable		 5cymA-5hl6A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5hl6 PUTATIVE GAF SENSOR
PROTEIN
(Burkholderia
vietnamiensis) 		5 / 12 LEU A  19
VAL A 134
TYR A  45
LEU A  48
TYR A  16
 None
 1.27A 5cyqA-5hl6A:
undetectable		 5cyqA-5hl6A:
14.18