SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hl8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 5hl8 TYPE II SECRETION
SYSTEM PROTEIN L
(Klebsiella
pneumoniae) 		4 / 8 PHE A 364
ILE A 328
PHE A 372
LEU A 351
 None
 0.88A 1fslB-5hl8A:
undetectable		 1fslB-5hl8A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 5hl8 TYPE II SECRETION
SYSTEM PROTEIN L
(Klebsiella
pneumoniae) 		5 / 12 LEU A 390
ILE A 353
ALA A 368
PHE A 364
LEU A 329
 None
 1.13A 2qb4A-5hl8A:
undetectable		 2qb4A-5hl8A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 5hl8 TYPE II SECRETION
SYSTEM PROTEIN L
(Klebsiella
pneumoniae) 		5 / 11 LEU A 390
ILE A 353
ALA A 368
PHE A 364
LEU A 329
 None
 1.18A 2qjuA-5hl8A:
undetectable		 2qjuA-5hl8A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 5hl8 TYPE II SECRETION
SYSTEM PROTEIN L
(Klebsiella
pneumoniae) 		4 / 5 ASP A 352
GLU A 387
GLY A 388
GLN A 350
 None
 1.25A 3w9tE-5hl8A:
undetectable		 3w9tE-5hl8A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 5hl8 TYPE II SECRETION
SYSTEM PROTEIN L
(Klebsiella
pneumoniae) 		4 / 5 ASP A 352
GLU A 387
GLY A 388
GLN A 350
 None
 1.29A 3w9tG-5hl8A:
undetectable		 3w9tG-5hl8A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 5hl8 TYPE II SECRETION
SYSTEM PROTEIN L
(Klebsiella
pneumoniae) 		4 / 8 ARG A 371
ARG A 373
GLU A 393
HIS A 315
 None
 1.41A 3zmdA-5hl8A:
undetectable
3zmdB-5hl8A:
undetectable		 3zmdA-5hl8A:
23.39
3zmdB-5hl8A:
23.39