SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hlb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 6 LEU A 229
LEU A 316
LEU A 394
LEU A 390
 None
 0.80A 1errA-5hlbA:
undetectable		 1errA-5hlbA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		6 / 12 SER A 510
LYS A 513
SER A 572
ASN A 574
LYS A 698
GLY A 700
 AZR  A 902 (-1.4A)
AZR  A 902 ( 4.0A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.3A)
 0.38A 1ghmA-5hlbA:
16.6		 1ghmA-5hlbA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		7 / 12 SER A 510
LYS A 513
SER A 572
ASN A 574
THR A 682
LYS A 698
GLY A 700
 AZR  A 902 (-1.4A)
AZR  A 902 ( 4.0A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.3A)
 0.61A 1i2wA-5hlbA:
17.2		 1i2wA-5hlbA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		6 / 12 SER A 510
LYS A 513
SER A 572
ASN A 574
THR A 682
GLY A 700
 AZR  A 902 (-1.4A)
AZR  A 902 ( 4.0A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 (-3.4A)
AZR  A 902 (-3.3A)
 0.59A 1i2wB-5hlbA:
17.3		 1i2wB-5hlbA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7G_A_BCZA801_0
(NEURAMINIDASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 12 LEU A 128
ASP A 198
ARG A 156
GLU A 340
GLU A 341
 None
 1.49A 1l7gA-5hlbA:
undetectable		 1l7gA-5hlbA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 12 LEU A 417
ALA A 449
ALA A 453
ALA A 450
VAL A 484
 None
 1.34A 1rbpA-5hlbA:
undetectable		 1rbpA-5hlbA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		3 / 3 PHE A  76
TYR A 292
TYR A  83
 None
 0.96A 1x70B-5hlbA:
undetectable		 1x70B-5hlbA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 8 PHE A 480
ARG A 660
ALA A 667
LEU A 757
 None
 1.16A 1x8vA-5hlbA:
undetectable		 1x8vA-5hlbA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		7 / 12 SER A 510
LYS A 513
SER A 572
ASN A 574
THR A 682
LYS A 698
GLY A 700
 AZR  A 902 (-1.4A)
AZR  A 902 ( 4.0A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.3A)
 0.61A 1ymxA-5hlbA:
18.3		 1ymxA-5hlbA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		6 / 12 SER A 510
LYS A 513
SER A 572
ASN A 574
LYS A 698
GLY A 700
 AZR  A 902 (-1.4A)
AZR  A 902 ( 4.0A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.3A)
 0.44A 1ymxB-5hlbA:
18.3		 1ymxB-5hlbA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 11 ASN A 749
THR A 719
ILE A 474
ARG A 745
THR A 472
 None
 1.12A 2f9wA-5hlbA:
undetectable
2f9wB-5hlbA:
undetectable		 2f9wA-5hlbA:
16.46
2f9wB-5hlbA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 8 ARG A 745
THR A 472
THR A 719
ILE A 474
 None
 0.92A 2f9wA-5hlbA:
undetectable
2f9wB-5hlbA:
undetectable		 2f9wA-5hlbA:
16.46
2f9wB-5hlbA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 8 LEU A 394
LEU A 342
VAL A 401
GLY A 400
 None
 0.93A 2po5A-5hlbA:
undetectable		 2po5A-5hlbA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 11 ALA A 171
LEU A 128
ILE A 152
ILE A 119
PHE A 175
 None
 1.06A 2w9sB-5hlbA:
undetectable		 2w9sB-5hlbA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y4N_B_PACB503_0
(PHENYLACETATE-COENZY
ME A LIGASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 4 SER A 741
GLY A 683
GLY A 687
LYS A 689
 None
 1.49A 2y4nB-5hlbA:
undetectable		 2y4nB-5hlbA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 4 LEU A 569
GLN A 676
THR A 673
THR A 699
 None
None
None
AZR  A 902 (-3.5A)
 1.50A 2zj0D-5hlbA:
undetectable		 2zj0D-5hlbA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 12 SER A 716
MET A 154
PHE A 175
ILE A 152
ASP A 443
 None
 1.47A 3aocC-5hlbA:
undetectable		 3aocC-5hlbA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 12 GLY A 509
ALA A 613
LEU A 614
PRO A 514
PHE A 625
 AZR  A 902 ( 3.9A)
None
None
None
None
 0.95A 3dmhA-5hlbA:
undetectable		 3dmhA-5hlbA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 7 MET A 204
LEU A 201
SER A 319
GLY A 326
 None
 1.00A 3hcnA-5hlbA:
undetectable		 3hcnA-5hlbA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_A_CE3A301_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		6 / 12 LYS A 513
SER A 572
ASN A 574
THR A 682
LYS A 698
GLY A 700
 AZR  A 902 ( 4.0A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.3A)
 0.58A 3hlwA-5hlbA:
18.3		 3hlwA-5hlbA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		6 / 12 SER A 572
ASN A 574
THR A 682
LYS A 698
THR A 699
GLY A 700
 AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
 0.53A 3hlwB-5hlbA:
18.3		 3hlwB-5hlbA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 12 LYS A 513
ASN A 574
LYS A 698
THR A 699
GLY A 700
 AZR  A 902 ( 4.0A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
 0.47A 3huoA-5hlbA:
18.4		 3huoA-5hlbA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 12 LEU A 128
ASP A 198
ARG A 156
GLU A 340
GLU A 341
 None
 1.39A 3k39C-5hlbA:
undetectable		 3k39C-5hlbA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 12 LEU A 128
ASP A 198
ARG A 156
GLU A 340
GLU A 341
 None
 1.40A 3k39D-5hlbA:
undetectable		 3k39D-5hlbA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 12 LEU A 128
ASP A 198
ARG A 156
GLU A 340
GLU A 341
 None
 1.40A 3k39I-5hlbA:
undetectable		 3k39I-5hlbA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 12 LEU A 128
ASP A 198
ARG A 156
GLU A 340
GLU A 341
 None
 1.40A 3k39J-5hlbA:
undetectable		 3k39J-5hlbA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 12 LEU A 128
ASP A 198
ARG A 156
GLU A 340
GLU A 341
 None
 1.39A 3k39K-5hlbA:
undetectable		 3k39K-5hlbA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 12 LEU A 128
ASP A 198
ARG A 156
GLU A 340
GLU A 341
 None
 1.38A 3k39L-5hlbA:
undetectable		 3k39L-5hlbA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 11 ALA A 696
ILE A 713
GLY A 712
LEU A 671
ALA A 629
 None
 1.05A 3kw2A-5hlbA:
undetectable		 3kw2A-5hlbA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		6 / 12 SER A 510
LYS A 513
ASN A 574
THR A 699
GLY A 700
THR A 702
 AZR  A 902 (-1.4A)
AZR  A 902 ( 4.0A)
AZR  A 902 (-3.4A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
AZR  A 902 (-4.1A)
 0.87A 3mzeA-5hlbA:
15.1		 3mzeA-5hlbA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA308_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		7 / 12 SER A 510
SER A 572
THR A 682
LYS A 698
THR A 699
GLY A 700
THR A 701
 AZR  A 902 (-1.4A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
AZR  A 902 (-4.3A)
 0.67A 3ny4A-5hlbA:
17.5		 3ny4A-5hlbA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 12 LYS A 513
SER A 572
ASN A 574
LYS A 698
GLY A 700
 AZR  A 902 ( 4.0A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.3A)
 0.52A 3q07A-5hlbA:
18.3		 3q07A-5hlbA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 12 LYS A 513
SER A 572
ASN A 574
LYS A 698
GLY A 700
 AZR  A 902 ( 4.0A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.3A)
 0.58A 3q07B-5hlbA:
18.2		 3q07B-5hlbA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 7 VAL A 678
LEU A 686
TYR A 743
LEU A 511
 None
 1.03A 3qeoB-5hlbA:
undetectable		 3qeoB-5hlbA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		6 / 12 SER A 510
SER A 572
ASN A 574
LYS A 698
THR A 699
GLY A 700
 AZR  A 902 (-1.4A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
 0.38A 3sh8A-5hlbA:
18.0		 3sh8A-5hlbA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		6 / 12 SER A 510
LYS A 513
SER A 572
ASN A 574
LYS A 698
GLY A 700
 AZR  A 902 (-1.4A)
AZR  A 902 ( 4.0A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.3A)
 0.46A 3sh8B-5hlbA:
17.6		 3sh8B-5hlbA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		3 / 3 LEU A 272
MET A 293
ASP A  88
 None
 0.88A 3v5wA-5hlbA:
undetectable		 3v5wA-5hlbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 11 THR A 232
ALA A 231
LEU A 380
PHE A 327
VAL A 339
 None
 1.00A 4claA-5hlbA:
undetectable		 4claA-5hlbA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EUZ_A_MEMA401_1
(CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		8 / 12 LYS A 513
SER A 572
ASN A 574
THR A 682
LYS A 698
THR A 699
GLY A 700
THR A 701
 AZR  A 902 ( 4.0A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
AZR  A 902 (-4.3A)
 0.70A 4euzA-5hlbA:
18.0		 4euzA-5hlbA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 10 SER A 572
ASN A 574
LYS A 698
THR A 699
GLY A 700
 AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
 0.73A 4fh2A-5hlbA:
18.4		 4fh2A-5hlbA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 4 ASP A 234
LEU A 230
ARG A 218
THR A 267
 None
 1.37A 4kjjA-5hlbA:
undetectable		 4kjjA-5hlbA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 4 ASP A 234
LEU A 230
ARG A 218
THR A 267
 None
 1.40A 4kjkA-5hlbA:
undetectable		 4kjkA-5hlbA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 12 LEU A 128
ASP A 198
ARG A 156
GLU A 340
GLU A 341
 None
 1.44A 4mwvA-5hlbA:
undetectable		 4mwvA-5hlbA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		6 / 12 SER A 510
SER A 572
ASN A 574
LYS A 698
THR A 699
GLY A 700
 AZR  A 902 (-1.4A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
 0.42A 4n9kA-5hlbA:
17.8		 4n9kA-5hlbA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		6 / 12 SER A 510
SER A 572
ASN A 574
LYS A 698
THR A 699
GLY A 700
 AZR  A 902 (-1.4A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
 0.42A 4n9kB-5hlbA:
17.7		 4n9kB-5hlbA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 5 ASP A 234
LEU A 230
ARG A 218
THR A 267
 None
 1.37A 4p3qA-5hlbA:
undetectable		 4p3qA-5hlbA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		6 / 12 SER A 572
ASN A 574
THR A 682
LYS A 698
THR A 699
GLY A 700
 AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
 0.77A 4pm5A-5hlbA:
18.5		 4pm5A-5hlbA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM7_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		6 / 12 LYS A 513
SER A 572
ASN A 574
THR A 682
LYS A 698
GLY A 700
 AZR  A 902 ( 4.0A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.3A)
 0.81A 4pm7A-5hlbA:
18.5		 4pm7A-5hlbA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM9_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		6 / 12 SER A 572
ASN A 574
THR A 682
LYS A 698
THR A 699
GLY A 700
 AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
 0.74A 4pm9A-5hlbA:
18.3		 4pm9A-5hlbA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA907_0
(PROTEIN ARGONAUTE-2)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 5 ALA A 450
THR A 719
THR A 721
TYR A 743
 None
 1.32A 4w5oA-5hlbA:
undetectable		 4w5oA-5hlbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 6 ALA A 450
THR A 719
THR A 721
TYR A 743
 None
 1.30A 4w5qA-5hlbA:
undetectable		 4w5qA-5hlbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 6 ALA A 450
THR A 719
THR A 721
TYR A 743
 None
 1.32A 4w5rA-5hlbA:
undetectable		 4w5rA-5hlbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 6 ALA A 450
THR A 719
THR A 721
TYR A 743
 None
 1.30A 4w5tA-5hlbA:
undetectable		 4w5tA-5hlbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 6 ALA A 450
THR A 719
THR A 721
TYR A 743
 None
 1.34A 4z4cA-5hlbA:
undetectable		 4z4cA-5hlbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 5 ALA A 450
THR A 719
THR A 721
TYR A 743
 None
 1.34A 4z4dA-5hlbA:
undetectable		 4z4dA-5hlbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA907_0
(PROTEIN ARGONAUTE-2)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 5 ALA A 450
THR A 719
THR A 721
TYR A 743
 None
 1.33A 4z4eA-5hlbA:
undetectable		 4z4eA-5hlbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 6 ALA A 450
THR A 719
THR A 721
TYR A 743
 None
 1.29A 4z4fA-5hlbA:
undetectable		 4z4fA-5hlbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 5 ALA A 450
THR A 719
THR A 721
TYR A 743
 None
 1.33A 4z4gA-5hlbA:
undetectable		 4z4gA-5hlbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 6 ALA A 450
THR A 719
THR A 721
TYR A 743
 None
 1.31A 4z4iA-5hlbA:
undetectable		 4z4iA-5hlbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		3 / 3 ARG A 745
LYS A 452
GLU A 456
 None
 0.82A 5d0yA-5hlbA:
undetectable		 5d0yA-5hlbA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		6 / 11 SER A 510
SER A 572
ASN A 574
LYS A 698
THR A 699
GLY A 700
 AZR  A 902 (-1.4A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
 0.41A 5ghzA-5hlbA:
17.6		 5ghzA-5hlbA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_B_CEDB301_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		6 / 10 SER A 510
SER A 572
ASN A 574
LYS A 698
THR A 699
GLY A 700
 AZR  A 902 (-1.4A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
 0.41A 5ghzB-5hlbA:
17.8		 5ghzB-5hlbA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 10 LEU A 637
ALA A 658
GLY A 631
ILE A 628
VAL A 477
 None
 1.03A 5kr1A-5hlbA:
undetectable		 5kr1A-5hlbA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		3 / 3 THR A 753
SER A 716
ASP A 443
 None
 0.69A 5kvaB-5hlbA:
undetectable		 5kvaB-5hlbA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		6 / 12 ARG A 555
SER A 572
ASN A 574
THR A 682
GLY A 700
THR A 701
 None
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 (-3.4A)
AZR  A 902 (-3.3A)
AZR  A 902 (-4.3A)
 1.44A 5oj0A-5hlbA:
25.8		 5oj0A-5hlbA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 12 PHE A 327
LEU A 229
THR A 232
TYR A 334
SER A 331
 None
 1.40A 5v1tA-5hlbA:
undetectable		 5v1tA-5hlbA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 5 GLY A 427
ASP A 428
GLN A 420
MET A 502
 None
 1.20A 5zrfB-5hlbA:
undetectable		 5zrfB-5hlbA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_B_9F2B400_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		7 / 12 SER A 510
SER A 572
THR A 682
LYS A 698
THR A 699
GLY A 700
THR A 701
 AZR  A 902 (-1.4A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
AZR  A 902 (-4.3A)
 0.63A 6b5yB-5hlbA:
17.7		 6b5yB-5hlbA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_D_9F2D400_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		7 / 12 SER A 510
SER A 572
THR A 682
LYS A 698
THR A 699
GLY A 700
THR A 701
 AZR  A 902 (-1.4A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
AZR  A 902 (-4.3A)
 0.69A 6b5yD-5hlbA:
17.6		 6b5yD-5hlbA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_B_9F2B301_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		7 / 12 SER A 510
SER A 572
THR A 682
LYS A 698
THR A 699
GLY A 700
THR A 701
 AZR  A 902 (-1.4A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
AZR  A 902 (-4.3A)
 0.52A 6b68B-5hlbA:
17.6		 6b68B-5hlbA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_D_9F2D400_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		6 / 12 SER A 510
SER A 572
THR A 682
LYS A 698
GLY A 700
THR A 701
 AZR  A 902 (-1.4A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.3A)
AZR  A 902 (-4.3A)
 0.58A 6b68D-5hlbA:
17.6		 6b68D-5hlbA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		7 / 12 SER A 510
SER A 572
THR A 682
LYS A 698
THR A 699
GLY A 700
THR A 701
 AZR  A 902 (-1.4A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
AZR  A 902 (-4.3A)
 0.51A 6b69A-5hlbA:
17.7
6b69B-5hlbA:
17.6		 6b69A-5hlbA:
8.41
6b69B-5hlbA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_D_9F2D301_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		7 / 12 SER A 510
SER A 572
THR A 682
LYS A 698
THR A 699
GLY A 700
THR A 701
 AZR  A 902 (-1.4A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
AZR  A 902 (-4.3A)
 0.48A 6b69D-5hlbA:
17.6		 6b69D-5hlbA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		7 / 12 SER A 510
SER A 572
THR A 682
LYS A 698
THR A 699
GLY A 700
THR A 701
 AZR  A 902 (-1.4A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
AZR  A 902 (-4.3A)
 0.55A 6b6aB-5hlbA:
17.7		 6b6aB-5hlbA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_D_9F2D301_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		6 / 12 SER A 510
SER A 572
LYS A 698
THR A 699
GLY A 700
THR A 701
 AZR  A 902 (-1.4A)
AZR  A 902 ( 3.7A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
AZR  A 902 (-4.3A)
 0.50A 6b6aD-5hlbA:
17.5		 6b6aD-5hlbA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6C_A_9F2A301_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		6 / 12 SER A 510
SER A 572
LYS A 698
THR A 699
GLY A 700
THR A 701
 AZR  A 902 (-1.4A)
AZR  A 902 ( 3.7A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
AZR  A 902 (-4.3A)
 0.66A 6b6cA-5hlbA:
17.7		 6b6cA-5hlbA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6D_A_9F2A302_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		7 / 12 SER A 510
SER A 572
THR A 682
LYS A 698
THR A 699
GLY A 700
THR A 701
 AZR  A 902 (-1.4A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
AZR  A 902 (-4.3A)
 0.63A 6b6dA-5hlbA:
17.6		 6b6dA-5hlbA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		7 / 12 SER A 510
SER A 572
THR A 682
LYS A 698
THR A 699
GLY A 700
THR A 701
 AZR  A 902 (-1.4A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
AZR  A 902 (-4.3A)
 0.54A 6b6eA-5hlbA:
17.8		 6b6eA-5hlbA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6F_A_9F2A301_1
(BETA-LACTAMASE)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		6 / 12 SER A 510
SER A 572
LYS A 698
THR A 699
GLY A 700
THR A 701
 AZR  A 902 (-1.4A)
AZR  A 902 ( 3.7A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.5A)
AZR  A 902 (-3.3A)
AZR  A 902 (-4.3A)
 0.75A 6b6fA-5hlbA:
17.5		 6b6fA-5hlbA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 12 SER A 572
ASN A 574
THR A 682
LYS A 698
GLY A 700
 AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.3A)
 0.47A 6c79A-5hlbA:
18.4		 6c79A-5hlbA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 12 TRP A 672
LEU A 783
VAL A 785
THR A 787
PHE A 774
 None
 1.29A 6drxA-5hlbA:
undetectable		 6drxA-5hlbA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		5 / 12 ALA A 711
THR A 673
VAL A 718
VAL A 477
TYR A 746
 None
 1.40A 6hu9N-5hlbA:
undetectable		 6hu9N-5hlbA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 7 ASP A  96
ARG A  92
TYR A 301
ASP A  88
 None
 1.18A 6mn5E-5hlbA:
undetectable		 6mn5E-5hlbA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 5hlb PENICILLIN-BINDING
PROTEIN 1B
(Escherichia
coli) 		4 / 7 ALA A 739
GLY A 738
LEU A 733
GLY A 683
 None
 0.85A 6nm4A-5hlbA:
undetectable		 6nm4A-5hlbA:
14.35