SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hm1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LQU_B_ACTB1424_0 (FPRA)	5hm1	LAMA VHH ANTIBODY 2E7 (Lama glama)	4 / 4	ALA A 88 ARG A 38 GLN A 39 GLU A 46	None	1.39A	1lquB-5hm1A: undetectable	1lquB-5hm1A: 18.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXT_B_MTXB2000_1 (ANTI-METHOTREXATE CDR1-3 GRAFT VHH)	5hm1	LAMA VHH ANTIBODY 2E7 (Lama glama)	6 / 12	VAL A 2 LEU A 4 ALA A 24 VAL A 78 ALA A 94 TYR A 102	None	0.74A	3qxtB-5hm1A: 18.7	3qxtB-5hm1A: 68.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXV_B_MTXB2000_1 (ANTI-METHOTREXATE CDR1-4 GRAFT VHH)	5hm1	LAMA VHH ANTIBODY 2E7 (Lama glama)	5 / 12	VAL A 2 ALA A 24 VAL A 78 ALA A 94 TYR A 102	None	0.64A	3qxvB-5hm1A: 18.6	3qxvB-5hm1A: 68.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXV_D_MTXD2000_1 (ANTI-METHOTREXATE CDR1-4 GRAFT VHH)	5hm1	LAMA VHH ANTIBODY 2E7 (Lama glama)	5 / 12	VAL A 2 ALA A 24 VAL A 78 ALA A 94 TYR A 102	None	0.69A	3qxvD-5hm1A: 18.7	3qxvD-5hm1A: 68.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6CJK_B_ACTB302_0 (IMMUNOGLOBULIN FAB HEAVY CHAIN)	5hm1	LAMA VHH ANTIBODY 2E7 (Lama glama)	3 / 3	TYR A 59 GLY A 65 THR A 68	None	0.18A	6cjkB-5hm1A: 17.4	6cjkB-5hm1A: 52.07

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1LQU_B_ACTB1424_0","FPRA","5hm1","LAMA VHH ANTIBODY 2E7","Lama glama",4,"ALA A  88;ARG A  38;GLN A  39;GLU A  46","None","1.39A","1lquB-5hm1A:undetectable","1lquB-5hm1A:18.06"],["3QXT_B_MTXB2000_1","ANTI-METHOTREXATE CDR1-3 GRAFT VHH","5hm1","LAMA VHH ANTIBODY 2E7","Lama glama",6,"VAL A   2;LEU A   4;ALA A  24;VAL A  78;ALA A  94;TYR A 102","None","0.74A","3qxtB-5hm1A:18.7","3qxtB-5hm1A:68.80"],["3QXV_B_MTXB2000_1","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","5hm1","LAMA VHH ANTIBODY 2E7","Lama glama",5,"VAL A   2;ALA A  24;VAL A  78;ALA A  94;TYR A 102","None","0.64A","3qxvB-5hm1A:18.6","3qxvB-5hm1A:68.00"],["3QXV_D_MTXD2000_1","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","5hm1","LAMA VHH ANTIBODY 2E7","Lama glama",5,"VAL A   2;ALA A  24;VAL A  78;ALA A  94;TYR A 102","None","0.69A","3qxvD-5hm1A:18.7","3qxvD-5hm1A:68.00"],["6CJK_B_ACTB302_0","IMMUNOGLOBULIN FAB HEAVY CHAIN","5hm1","LAMA VHH ANTIBODY 2E7","Lama glama",3,"TYR A  59;GLY A  65;THR A  68","None","0.18A","6cjkB-5hm1A:17.4","6cjkB-5hm1A:52.07"]]