SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hm2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hm2 3C PROTEINASE
(Foot-and-mouth
disease
virus) 		5 / 11 SER A 182
SER A  83
VAL A  36
PHE A 103
VAL A 194
 None
 1.44A 1q23J-5hm2A:
undetectable		 1q23J-5hm2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 5hm2 3C PROTEINASE
(Foot-and-mouth
disease
virus) 		4 / 7 LEU A 199
ALA A  40
GLY A  35
PHE A 103
 None
 0.97A 2wq5A-5hm2A:
undetectable		 2wq5A-5hm2A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5hm2 3C PROTEINASE
(Foot-and-mouth
disease
virus) 		5 / 12 HIS A  46
ASP A  84
GLY A 161
ALA A 163
ALA A 183
 None
 0.76A 3sudA-5hm2A:
9.8		 3sudA-5hm2A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5hm2 3C PROTEINASE
(Foot-and-mouth
disease
virus) 		5 / 12 HIS A  46
ASP A  84
GLY A 161
ALA A 163
ALA A 183
 None
 0.81A 3sudB-5hm2A:
10.0		 3sudB-5hm2A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5hm2 3C PROTEINASE
(Foot-and-mouth
disease
virus) 		5 / 12 HIS A  46
ASP A  84
GLY A 161
ALA A 163
ALA A 183
 None
 0.89A 3sudC-5hm2A:
0.4		 3sudC-5hm2A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5hm2 3C PROTEINASE
(Foot-and-mouth
disease
virus) 		5 / 12 HIS A  46
ASP A  84
GLY A 161
ALA A 163
ALA A 183
 None
 0.83A 3sudD-5hm2A:
10.4		 3sudD-5hm2A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5hm2 3C PROTEINASE
(Foot-and-mouth
disease
virus) 		4 / 6 LYS A 203
ILE A 206
VAL A  89
LEU A  87
 None
 1.09A 4em2A-5hm2A:
undetectable		 4em2A-5hm2A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 5hm2 3C PROTEINASE
(Foot-and-mouth
disease
virus) 		5 / 12 GLY A 157
ALA A 156
GLY A 187
THR A 135
GLY A 185
 None
 0.95A 4o3fA-5hm2A:
undetectable		 4o3fA-5hm2A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 5hm2 3C PROTEINASE
(Foot-and-mouth
disease
virus) 		4 / 6 GLY A 161
TYR A 162
GLY A 164
ASN A 121
 None
 0.92A 5k4pA-5hm2A:
undetectable		 5k4pA-5hm2A:
21.94