SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hm5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 ASP A 219
ARG A 151
TYR A 149
THR A  96
 None
 1.40A 1ceaA-5hm5A:
undetectable
1ceaB-5hm5A:
undetectable		 1ceaA-5hm5A:
7.90
1ceaB-5hm5A:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ILE A 380
ALA A 382
PHE A 374
ARG A 396
LEU A 397
 None
 1.23A 1ddrB-5hm5A:
undetectable		 1ddrB-5hm5A:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 9 ILE A 740
VAL A 704
GLY A 705
ALA A 744
LEU A 748
 None
 1.01A 1e7bA-5hm5A:
undetectable		 1e7bA-5hm5A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 10 ARG A 308
PRO A 330
TYR A 331
PRO A 364
ALA A 367
 None
 1.41A 1mskA-5hm5A:
undetectable		 1mskA-5hm5A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A  27
ILE A 278
MET A  40
ARG A 112
 None
 1.12A 1opjB-5hm5A:
undetectable		 1opjB-5hm5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 PHE A 576
ALA A 581
LEU A 584
ILE A 594
 None
 1.04A 1sbrA-5hm5A:
undetectable
1sbrB-5hm5A:
undetectable		 1sbrA-5hm5A:
12.88
1sbrB-5hm5A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_A_PAUA6001_0
(PANTOTHENATE KINASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 9 ASP A 532
LEU A 528
LEU A 502
TYR A 491
ILE A 473
 None
 1.33A 1sq5A-5hm5A:
undetectable		 1sq5A-5hm5A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_B_PAUB6003_0
(PANTOTHENATE KINASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 10 ASP A 532
LEU A 528
LEU A 502
TYR A 491
ILE A 473
 None
 1.33A 1sq5B-5hm5A:
undetectable		 1sq5B-5hm5A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_C_PAUC6002_0
(PANTOTHENATE KINASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 9 ASP A 532
LEU A 528
LEU A 502
TYR A 491
ILE A 473
 None
 1.37A 1sq5C-5hm5A:
undetectable		 1sq5C-5hm5A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 10 ASP A 532
LEU A 528
LEU A 502
TYR A 491
ILE A 473
 None
 1.34A 1sq5D-5hm5A:
undetectable		 1sq5D-5hm5A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 4 LYS A  28
LEU A 254
LEU A  62
SER A  65
 None
 1.42A 1tt6A-5hm5A:
undetectable		 1tt6A-5hm5A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 TYR A  30
ARG A 288
GLN A 292
 None
 0.87A 1tw4A-5hm5A:
undetectable		 1tw4A-5hm5A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 4 LYS A  28
LEU A 254
LEU A  62
SER A  65
 None
 1.41A 1tz8D-5hm5A:
undetectable		 1tz8D-5hm5A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 LEU A 760
GLY A 759
LYS A 796
LEU A 792
 None
 0.87A 1ya4A-5hm5A:
undetectable		 1ya4A-5hm5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 CYH A  68
PRO A  72
THR A  63
SER A  65
 None
 1.20A 1ymxA-5hm5A:
undetectable		 1ymxA-5hm5A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		6 / 12 ILE A 380
ALA A 382
PHE A 374
ARG A 396
LEU A 397
ILE A 388
 None
 1.22A 2d0kB-5hm5A:
undetectable		 2d0kB-5hm5A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 PHE A  87
ILE A 225
THR A  96
ARG A  90
GLU A 375
 None
 1.19A 2j0dA-5hm5A:
undetectable		 2j0dA-5hm5A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 LEU A 315
ASP A 340
ASP A 310
GLU A 345
 None
 1.23A 2j2pE-5hm5A:
undetectable
2j2pF-5hm5A:
undetectable		 2j2pE-5hm5A:
13.12
2j2pF-5hm5A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 GLU A 171
ILE A 174
GLU A 186
ILE A 181
 None
 0.85A 2j9dJ-5hm5A:
undetectable
2j9dK-5hm5A:
undetectable
2j9dL-5hm5A:
undetectable		 2j9dJ-5hm5A:
9.72
2j9dK-5hm5A:
9.72
2j9dL-5hm5A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 GLU A 186
ILE A 181
GLU A 171
ILE A 174
 None
 0.93A 2j9dJ-5hm5A:
undetectable
2j9dK-5hm5A:
undetectable
2j9dL-5hm5A:
undetectable		 2j9dJ-5hm5A:
9.72
2j9dK-5hm5A:
9.72
2j9dL-5hm5A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 VAL A 152
THR A 242
ARG A 245
LYS A 248
 None
 1.15A 2kotA-5hm5A:
undetectable		 2kotA-5hm5A:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ARG A 108
ALA A  67
ILE A  60
ALA A 127
ILE A 128
 None
 0.94A 2nmyB-5hm5A:
undetectable		 2nmyB-5hm5A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 VAL A 106
THR A  96
ARG A 144
ILE A 145
SER A 227
 None
 1.42A 2vdyA-5hm5A:
undetectable		 2vdyA-5hm5A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 ARG A 231
ARG A 436
PRO A 220
 None
 1.12A 2wljA-5hm5A:
2.1		 2wljA-5hm5A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 10 ARG A 108
ALA A  67
ILE A  60
ALA A 127
ILE A 128
 None
 1.00A 3ekwA-5hm5A:
undetectable		 3ekwA-5hm5A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ARG A 108
ALA A  67
ILE A  60
ALA A 127
ILE A 128
 None
 0.91A 3ekwB-5hm5A:
undetectable		 3ekwB-5hm5A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 LEU A 142
ALA A 167
PRO A 163
PRO A 156
 None
 1.24A 3gv1A-5hm5A:
undetectable
3gv1B-5hm5A:
undetectable		 3gv1A-5hm5A:
9.48
3gv1B-5hm5A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 GLU A 435
LEU A 397
ARG A 390
GLY A 432
LEU A 385
 None
 1.23A 3j6pB-5hm5A:
undetectable		 3j6pB-5hm5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 VAL A  27
ILE A 278
MET A  40
ARG A 112
 None
 1.27A 3oezA-5hm5A:
undetectable		 3oezA-5hm5A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 VAL A 437
VAL A 419
LEU A 413
GLY A 456
LEU A 463
 None
 1.09A 3pghA-5hm5A:
0.0		 3pghA-5hm5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 VAL A  27
ILE A 278
MET A  40
ARG A 112
 None
 1.14A 3pyyB-5hm5A:
undetectable		 3pyyB-5hm5A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 8 TYR A 103
LEU A  94
ALA A 382
SER A 222
SER A 227
 None
 1.45A 3rodA-5hm5A:
undetectable		 3rodA-5hm5A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 PHE A 374
TYR A 402
LEU A 353
 None
 0.65A 3sueB-5hm5A:
undetectable		 3sueB-5hm5A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 LEU A  24
PHE A  23
PRO A 126
ALA A 115
 None
 1.37A 3vm4A-5hm5A:
undetectable		 3vm4A-5hm5A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 ARG A 461
ARG A 458
ILE A 471
 None
 0.88A 4b7qC-5hm5A:
undetectable		 4b7qC-5hm5A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 TYR A 177
LEU A 173
LEU A 154
ARG A 151
 None
 1.48A 4em2A-5hm5A:
2.5		 4em2A-5hm5A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 SER A  99
GLU A  19
GLU A  18
GLY A  26
 None
 0.95A 4fgzA-5hm5A:
undetectable
4fgzB-5hm5A:
undetectable		 4fgzA-5hm5A:
15.67
4fgzB-5hm5A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 ASP A 124
ARG A 283
ASP A 121
 None
 0.90A 4fp9C-5hm5A:
undetectable		 4fp9C-5hm5A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 ASP A 559
ARG A 553
ASP A 577
 None
 0.80A 4fp9D-5hm5A:
undetectable		 4fp9D-5hm5A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 ASP A 124
ARG A 283
ASP A 121
 None
 0.87A 4fp9F-5hm5A:
undetectable		 4fp9F-5hm5A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 ALA A 404
GLU A 369
LEU A 370
LEU A 362
 None
 1.05A 4iomA-5hm5A:
undetectable		 4iomA-5hm5A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 ALA A 113
THR A 333
VAL A 337
PHE A 319
 None
 1.01A 4ltwA-5hm5A:
undetectable		 4ltwA-5hm5A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 10 VAL A 437
VAL A 419
LEU A 413
GLY A 456
LEU A 463
 None
 1.10A 4ph9A-5hm5A:
undetectable		 4ph9A-5hm5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 10 VAL A 437
VAL A 419
LEU A 413
GLY A 456
LEU A 463
 None
 1.09A 4ph9B-5hm5A:
undetectable		 4ph9B-5hm5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 LEU A 207
THR A 198
LEU A 209
SER A 210
 None
 0.94A 4pwjB-5hm5A:
undetectable		 4pwjB-5hm5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 LEU A 207
THR A 198
LEU A 209
SER A 210
 None
 0.92A 5bojB-5hm5A:
undetectable		 5bojB-5hm5A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 GLY A 793
ASP A 794
ARG A 788
GLY A 791
 None
 0.91A 5cdnC-5hm5A:
2.3
5cdnD-5hm5A:
undetectable		 5cdnC-5hm5A:
22.07
5cdnD-5hm5A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 GLY A 793
ASP A 794
ARG A 788
GLY A 791
 None
 0.91A 5cdnT-5hm5A:
undetectable
5cdnU-5hm5A:
undetectable		 5cdnT-5hm5A:
22.07
5cdnU-5hm5A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ILE A 380
ALA A 382
PHE A 374
ARG A 396
LEU A 397
 None
 1.14A 5e8qB-5hm5A:
undetectable		 5e8qB-5hm5A:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 TYR A 289
LEU A 261
ILE A 278
ILE A 285
MET A 286
 None
 1.27A 5ifuA-5hm5A:
undetectable		 5ifuA-5hm5A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 TRP A 277
ASP A  31
LEU A  34
GLY A  32
ILE A 285
 None
 0.99A 5j7wD-5hm5A:
undetectable		 5j7wD-5hm5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 HIS A 281
GLU A 280
TRP A 277
 None
 0.87A 5odiD-5hm5A:
undetectable		 5odiD-5hm5A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 HIS A 281
GLU A 280
TRP A 277
 None
 0.89A 5odqD-5hm5A:
undetectable		 5odqD-5hm5A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 HIS A 281
GLU A 280
TRP A 277
 None
 0.82A 5odrD-5hm5A:
undetectable		 5odrD-5hm5A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ARG A 135
ASN A 136
SER A  65
GLY A  64
THR A  63
 None
 1.24A 5oj0A-5hm5A:
undetectable		 5oj0A-5hm5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 VAL A  80
TYR A  77
GLN A  78
 None
 0.69A 5qgkA-5hm5A:
undetectable		 5qgkA-5hm5A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 VAL A  80
TYR A  77
GLN A  78
 None
 0.72A 5qgrA-5hm5A:
undetectable		 5qgrA-5hm5A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 VAL A  80
TYR A  77
GLN A  78
 None
 0.73A 5qgtA-5hm5A:
undetectable		 5qgtA-5hm5A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ILE A 380
ALA A 382
PHE A 374
ARG A 396
LEU A 397
 None
 1.06A 5ujxB-5hm5A:
undetectable		 5ujxB-5hm5A:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 ILE A 285
ARG A 276
THR A 274
LEU A 273
 None
 0.89A 5xdqA-5hm5A:
2.6
5xdqJ-5hm5A:
undetectable		 5xdqA-5hm5A:
19.50
5xdqJ-5hm5A:
5.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 LEU A 138
GLU A 161
VAL A 162
PRO A 156
SER A  69
 None
 1.48A 5xiqB-5hm5A:
undetectable		 5xiqB-5hm5A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 11 ARG A 308
PRO A 330
TYR A 331
PRO A 364
ALA A 367
 None
 1.38A 6bm5A-5hm5A:
undetectable		 6bm5A-5hm5A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
LEU A 154
LEU A 146
ARG A 151
 None
 0.97A 6e43A-5hm5A:
undetectable		 6e43A-5hm5A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
LEU A 154
LEU A 146
ARG A 151
 None
 0.98A 6e43B-5hm5A:
undetectable		 6e43B-5hm5A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
LEU A 154
LEU A 146
ARG A 151
 None
 0.99A 6e43C-5hm5A:
undetectable		 6e43C-5hm5A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
LEU A 154
LEU A 146
ARG A 151
 None
 0.96A 6e43D-5hm5A:
undetectable		 6e43D-5hm5A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 THR A  96
ARG A 148
GLN A 439
ASP A 178
 None
 1.34A 6ectA-5hm5A:
undetectable		 6ectA-5hm5A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 5hm5 TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
PRO A 180
ILE A 181
GLU A 185
 None
 1.17A 6h7uA-5hm5A:
undetectable		 6h7uA-5hm5A:
20.05