SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hm7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 5hm7 BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1
(Homo
sapiens) 		3 / 3 ALA A 446
VAL A 369
TRP A 367
 None
 0.92A 1c4dC-5hm7A:
undetectable
1c4dD-5hm7A:
undetectable		 1c4dC-5hm7A:
3.81
1c4dD-5hm7A:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 5hm7 BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1
(Homo
sapiens) 		5 / 10 LEU A 434
ALA A 310
ASP A 311
ILE A 480
GLY A 356
 None
 1.16A 1d4sA-5hm7A:
undetectable		 1d4sA-5hm7A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 5hm7 BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1
(Homo
sapiens) 		5 / 11 ALA A 319
PHE A 348
LEU A 355
VAL A 332
VAL A 325
 None
 1.15A 1ukbA-5hm7A:
undetectable		 1ukbA-5hm7A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5hm7 BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1
(Homo
sapiens) 		4 / 7 TYR A 411
VAL A 371
GLY A 372
THR A 476
 None
 0.81A 2a1mA-5hm7A:
undetectable		 2a1mA-5hm7A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 5hm7 BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1
(Homo
sapiens) 		5 / 11 LEU A 434
ALA A 310
ASP A 311
ILE A 480
VAL A 381
 None
 1.28A 3oxxB-5hm7A:
undetectable		 3oxxB-5hm7A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5hm7 BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1
(Homo
sapiens) 		4 / 8 LEU A 423
SER A 286
VAL A 432
GLY A 431
 None
 0.97A 4klrB-5hm7A:
undetectable		 4klrB-5hm7A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 5hm7 BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1
(Homo
sapiens) 		3 / 3 TYR A 366
LYS A 304
LYS A 303
 None
 1.12A 5dbyA-5hm7A:
undetectable		 5dbyA-5hm7A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5hm7 BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1
(Homo
sapiens) 		3 / 3 LYS A 425
PRO A 426
LYS A 428
 None
 0.65A 5y9yA-5hm7A:
undetectable		 5y9yA-5hm7A:
24.76