SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hmm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		5 / 12 ALA A 129
GLY A  27
PHE A 112
LEU A 149
PHE A 281
 None
 1.32A 1brpA-5hmmA:
undetectable		 1brpA-5hmmA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		5 / 11 SER A 249
LEU A 253
LEU A 234
VAL A 209
ILE A 243
 None
 0.85A 1ee2A-5hmmA:
4.3		 1ee2A-5hmmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		5 / 11 SER A 249
LEU A 253
LEU A 234
VAL A 209
ILE A 243
 None
 0.86A 1ee2B-5hmmA:
3.5		 1ee2B-5hmmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		5 / 10 LEU A 262
LEU A 159
ILE A 136
PHE A  74
ILE A 270
 None
 1.11A 1i18A-5hmmA:
undetectable
1i18B-5hmmA:
undetectable		 1i18A-5hmmA:
16.73
1i18B-5hmmA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		5 / 10 PHE A  74
ILE A 270
LEU A 262
LEU A 159
ILE A 136
 None
 1.11A 1i18A-5hmmA:
undetectable
1i18B-5hmmA:
undetectable		 1i18A-5hmmA:
16.73
1i18B-5hmmA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		3 / 3 HIS A  78
ASP A 261
ASN A 226
 None
 0.82A 1wg8B-5hmmA:
3.8		 1wg8B-5hmmA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		5 / 12 LEU A 159
TRP A 156
LEU A 149
GLY A  27
LEU A  66
 None
 1.11A 2jfaB-5hmmA:
undetectable		 2jfaB-5hmmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		5 / 12 THR A 158
ASP A 130
GLU A 128
LYS A  83
ASP A 204
 None
MG  A 302 ( 2.7A)
None
None
MG  A 304 ( 4.5A)
 1.42A 2zj0C-5hmmA:
2.8		 2zj0C-5hmmA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		5 / 12 THR A 158
GLU A 128
LYS A  83
ASP A 204
GLY A 154
 None
None
None
MG  A 304 ( 4.5A)
None
 1.33A 2zj0C-5hmmA:
2.8		 2zj0C-5hmmA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		5 / 12 THR A 158
ASP A 130
GLU A 128
LYS A  83
ASP A 204
 None
MG  A 302 ( 2.7A)
None
None
MG  A 304 ( 4.5A)
 1.42A 3ce6C-5hmmA:
2.8		 3ce6C-5hmmA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		5 / 12 THR A 158
GLU A 128
LYS A  83
ASP A 204
GLY A 154
 None
None
None
MG  A 304 ( 4.5A)
None
 1.33A 3ce6C-5hmmA:
2.8		 3ce6C-5hmmA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		5 / 12 THR A 158
ASP A 130
GLU A 128
LYS A  83
ASP A 204
 None
MG  A 302 ( 2.7A)
None
None
MG  A 304 ( 4.5A)
 1.43A 3ce6D-5hmmA:
2.7		 3ce6D-5hmmA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		5 / 12 THR A 158
GLU A 128
LYS A  83
ASP A 204
GLY A 154
 None
None
None
MG  A 304 ( 4.5A)
None
 1.34A 3ce6D-5hmmA:
2.7		 3ce6D-5hmmA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		5 / 10 ASP A 130
GLY A  67
GLY A  27
LEU A  30
ILE A  24
 MG  A 302 ( 2.7A)
None
None
None
None
 1.03A 3em4V-5hmmA:
undetectable		 3em4V-5hmmA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		5 / 12 GLU A 128
ARG A 255
ASP A 204
ILE A 206
ASN A 205
 None
None
MG  A 304 ( 4.5A)
None
None
 1.02A 3jayA-5hmmA:
undetectable		 3jayA-5hmmA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_B_URFB521_1
(RNA DEPENDENT RNA
POLYMERASE)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		4 / 4 ARG A  86
ASP A 130
ASP A 153
ASP A  26
 None
MG  A 302 ( 2.7A)
MG  A 303 (-3.0A)
MG  A 302 ( 4.1A)
 1.35A 3naiB-5hmmA:
undetectable		 3naiB-5hmmA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		5 / 12 ILE A 285
PHE A 281
ALA A 289
THR A  62
MET A 132
 None
 1.24A 3s79A-5hmmA:
undetectable		 3s79A-5hmmA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		4 / 7 LEU A 160
GLU A 182
HIS A 183
HIS A 184
 None
 1.30A 4aq7A-5hmmA:
undetectable		 4aq7A-5hmmA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		4 / 7 MET A  23
LEU A  30
THR A  63
THR A 121
 None
 0.82A 4ik7A-5hmmA:
undetectable		 4ik7A-5hmmA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		6 / 12 ILE A 212
VAL A 209
LEU A 252
LEU A 246
ALA A 197
LEU A 195
 None
 1.44A 4m11B-5hmmA:
undetectable		 4m11B-5hmmA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		3 / 3 ASP A 187
ARG A 222
TYR A 181
 None
 0.91A 5a7mA-5hmmA:
undetectable		 5a7mA-5hmmA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		3 / 3 ASP A 187
ARG A 222
TYR A 181
 None
 0.92A 5a7mB-5hmmA:
undetectable		 5a7mB-5hmmA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		3 / 3 GLU A 210
TYR A 242
ARG A 216
 None
EDO  A 301 (-4.6A)
EDO  A 301 (-3.8A)
 0.80A 5uunB-5hmmA:
undetectable		 5uunB-5hmmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		5 / 10 ARG A 255
ALA A 248
LEU A 253
VAL A 209
GLY A 208
 None
 1.37A 5zbdA-5hmmA:
1.8		 5zbdA-5hmmA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		4 / 6 ASP A 201
TYR A  82
GLU A 128
ASP A 130
 MG  A 304 (-2.8A)
None
None
MG  A 302 ( 2.7A)
 1.14A 6mn5A-5hmmA:
undetectable		 6mn5A-5hmmA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5hmm EXODEOXYRIBONUCLEASE
(Escherichia
virus
T5) 		4 / 6 ASP A 201
TYR A  82
GLU A 128
ASP A 130
 MG  A 304 (-2.8A)
None
None
MG  A 302 ( 2.7A)
 1.21A 6mn5C-5hmmA:
undetectable		 6mn5C-5hmmA:
14.02