SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hmp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		3 / 3 VAL A  83
TRP A  22
TRP A  14
 None
 1.12A 1c4dA-5hmpA:
undetectable
1c4dB-5hmpA:
undetectable		 1c4dA-5hmpA:
2.28
1c4dB-5hmpA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 12 ILE A 137
TYR A 173
TYR A 117
HIS A 645
ILE A 122
 None
None
ADP  A 803 (-4.6A)
None
None
 1.04A 1fmlB-5hmpA:
undetectable		 1fmlB-5hmpA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		4 / 8 SER A 170
ALA A 174
PHE A 178
ILE A 137
 None
 1.13A 1gm7A-5hmpA:
undetectable
1gm7B-5hmpA:
undetectable		 1gm7A-5hmpA:
14.23
1gm7B-5hmpA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		4 / 8 VAL A 624
LEU A 241
TYR A 437
GLU A 448
 None
 0.98A 1jtvA-5hmpA:
undetectable		 1jtvA-5hmpA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 11 THR A 222
ALA A 179
ILE A 122
ALA A 141
ASP A 119
 None
 1.29A 2admA-5hmpA:
undetectable		 2admA-5hmpA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		4 / 6 ASP A 443
PHE A 442
THR A 209
GLU A 254
 None
 1.20A 2dttB-5hmpA:
undetectable
2dttC-5hmpA:
undetectable		 2dttB-5hmpA:
10.46
2dttC-5hmpA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 12 GLU A 457
PHE A 439
LEU A 525
GLN A 549
ILE A 497
 None
 1.34A 2ogyA-5hmpA:
undetectable		 2ogyA-5hmpA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 10 LEU A 355
LEU A 574
VAL A 369
ILE A 405
PHE A 358
 None
 1.04A 2w9gA-5hmpA:
undetectable		 2w9gA-5hmpA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 10 LEU A 355
LEU A 574
VAL A 369
ILE A 405
PHE A 358
 None
 1.10A 2w9hA-5hmpA:
undetectable		 2w9hA-5hmpA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 11 ILE A 666
ASN A 456
LEU A 670
THR A  99
PRO A 652
 None
 1.35A 3a50B-5hmpA:
undetectable		 3a50B-5hmpA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 10 GLU A 162
ARG A 665
ILE A 666
LEU A  72
MET A 108
 None
 1.22A 3adsA-5hmpA:
undetectable		 3adsA-5hmpA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		4 / 5 ILE A 650
PRO A 652
PHE A 659
PRO A 110
 None
None
None
ADP  A 803 (-4.2A)
 1.34A 3bjwC-5hmpA:
0.9		 3bjwC-5hmpA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		4 / 7 LYS A 458
ASN A 490
TYR A 488
ASN A 533
 None
 1.43A 3frqB-5hmpA:
0.3		 3frqB-5hmpA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		4 / 7 VAL A 194
ILE A 431
THR A 429
GLY A 234
 None
 0.92A 3gssA-5hmpA:
undetectable		 3gssA-5hmpA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		3 / 3 HIS A  85
SER A  94
GLU A  93
 None
 0.83A 3s8pA-5hmpA:
undetectable		 3s8pA-5hmpA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 9 PHE A 226
ASN A 154
ILE A 431
GLY A 432
THR A 222
 None
 1.25A 3t3rB-5hmpA:
undetectable		 3t3rB-5hmpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 9 PHE A 226
ASN A 154
ILE A 431
GLY A 432
THR A 222
 None
 1.29A 3t3rC-5hmpA:
undetectable		 3t3rC-5hmpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 10 PHE A 226
ASN A 154
ILE A 431
GLY A 432
THR A 222
 None
 1.27A 3t3rD-5hmpA:
undetectable		 3t3rD-5hmpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		4 / 7 GLU A 457
ILE A 494
PHE A 551
HIS A 466
 None
 1.01A 4a97A-5hmpA:
undetectable		 4a97A-5hmpA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		4 / 6 GLU A 457
ILE A 494
PHE A 551
HIS A 466
 None
 1.00A 4a97I-5hmpA:
undetectable		 4a97I-5hmpA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		3 / 3 ARG A 648
ASP A 489
GLN A 491
 None
 0.72A 4azsA-5hmpA:
undetectable		 4azsA-5hmpA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		4 / 6 GLY A 561
ASN A 396
GLU A 564
GLN A 449
 None
 1.02A 4g0vB-5hmpA:
undetectable		 4g0vB-5hmpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		4 / 6 GLU A 448
ARG A 217
GLU A 243
SER A 245
 None
 1.08A 4kr3A-5hmpA:
undetectable		 4kr3A-5hmpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		4 / 5 ILE A 158
VAL A 159
PHE A 138
HIS A 466
 None
 1.28A 4rzvA-5hmpA:
undetectable		 4rzvA-5hmpA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		4 / 6 GLU A 537
PHE A 536
PHE A 546
TYR A 557
 None
 1.39A 4uciA-5hmpA:
undetectable		 4uciA-5hmpA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		4 / 7 GLU A 537
PHE A 536
PHE A 546
TYR A 557
 None
 1.40A 4uciB-5hmpA:
undetectable		 4uciB-5hmpA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 9 ARG A 398
LEU A 401
LEU A 364
ILE A 577
SER A 366
 DMS  A 805 (-3.4A)
None
None
None
None
 1.24A 4z69A-5hmpA:
2.6		 4z69A-5hmpA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 9 SER A 170
GLY A 438
SER A 163
ILE A 436
ALA A 455
 None
VO4  A 802 (-3.5A)
VO4  A 802 (-2.6A)
None
None
 1.43A 5entC-5hmpA:
undetectable		 5entC-5hmpA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 12 GLU A 223
LEU A 434
MET A 636
LEU A 632
ALA A 455
 None
 1.36A 5kbwA-5hmpA:
undetectable		 5kbwA-5hmpA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 12 PHE A  91
PHE A 661
ILE A 650
ALA A 107
GLY A  68
 None
 0.91A 5veuA-5hmpA:
undetectable		 5veuA-5hmpA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 12 PHE A  91
PHE A 661
ILE A 650
ALA A 107
GLY A  68
 None
 0.92A 5veuH-5hmpA:
undetectable		 5veuH-5hmpA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		4 / 9 LYS A 325
ILE A 326
ILE A 330
LEU A 333
 None
 0.71A 5vkqB-5hmpA:
2.5
5vkqC-5hmpA:
2.4		 5vkqB-5hmpA:
19.19
5vkqC-5hmpA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 10 TYR A 117
ILE A 121
PHE A 138
ALA A 107
LEU A 105
 ADP  A 803 (-4.6A)
None
None
None
None
 1.04A 5y7pH-5hmpA:
undetectable		 5y7pH-5hmpA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		4 / 5 GLU A 162
PHE A 439
ASP A 553
THR A 441
 None
 1.29A 6b58A-5hmpA:
0.3		 6b58A-5hmpA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		3 / 3 TYR A  77
PRO A  63
LEU A  66
 None
 0.77A 6beoA-5hmpA:
undetectable		 6beoA-5hmpA:
1.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 12 ILE A 158
GLY A 432
PHE A 430
ILE A 436
LEU A 635
 None
 0.97A 6dwnC-5hmpA:
0.0		 6dwnC-5hmpA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 12 ILE A 158
GLY A 432
PHE A 430
ILE A 436
LEU A 635
 None
 1.03A 6dwnD-5hmpA:
undetectable		 6dwnD-5hmpA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 12 VAL A 293
ASP A 213
ARG A 246
GLU A 243
GLY A 289
 None
 1.18A 6gnfC-5hmpA:
undetectable		 6gnfC-5hmpA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		4 / 8 VAL A 341
GLN A 371
ASN A 375
PRO A 388
 None
 1.03A 6hzpA-5hmpA:
1.8		 6hzpA-5hmpA:
21.60