SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hmq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 GLU A 280
ARG A 180
LEU A 228
ALA A 225
LEU A 224
 None
 1.26A 1hwkB-5hmqA:
undetectable		 1hwkB-5hmqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 GLU A 280
ARG A 180
LEU A 228
ALA A 225
LEU A 224
 None
 1.23A 1hwkA-5hmqA:
undetectable		 1hwkA-5hmqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 GLU A 280
ARG A 180
LEU A 228
ALA A 225
LEU A 224
 None
 1.25A 1hwkD-5hmqA:
undetectable		 1hwkD-5hmqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 GLU A 280
ARG A 180
LEU A 228
ALA A 225
LEU A 224
 None
 1.24A 1hwkC-5hmqA:
undetectable		 1hwkC-5hmqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 LEU A 448
SER A 407
LEU A 409
LEU A 495
MET A 444
 None
 1.14A 1mx1A-5hmqA:
undetectable		 1mx1A-5hmqA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 9 LEU A 299
PHE A 301
THR A 589
LEU A 318
LEU A 315
 None
 1.07A 1nr6A-5hmqA:
undetectable		 1nr6A-5hmqA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		4 / 7 VAL A   8
TYR A 263
ARG A 207
CYH A 211
 None
 0.91A 1t46A-5hmqA:
undetectable		 1t46A-5hmqA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		4 / 6 GLU A 471
ARG A 494
TYR A 607
TYR A 610
 None
 1.07A 1tufA-5hmqA:
2.6
1tufB-5hmqA:
3.0		 1tufA-5hmqA:
21.90
1tufB-5hmqA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 GLY A  28
VAL A  29
GLU A  30
ILE A  55
ARG A 130
 None
 1.01A 1vhwA-5hmqA:
undetectable
1vhwD-5hmqA:
undetectable		 1vhwA-5hmqA:
17.30
1vhwD-5hmqA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 GLY A  28
VAL A  29
GLU A  30
ILE A  55
ARG A 130
 None
 1.05A 1vhwC-5hmqA:
undetectable
1vhwE-5hmqA:
undetectable		 1vhwC-5hmqA:
17.30
1vhwE-5hmqA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 ARG A 130
GLY A  28
VAL A  29
GLU A  30
ILE A  55
 None
 1.03A 1vhwA-5hmqA:
undetectable
1vhwD-5hmqA:
undetectable		 1vhwA-5hmqA:
17.30
1vhwD-5hmqA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 ARG A 130
GLY A  28
VAL A  29
GLU A  30
ILE A  55
 None
 1.00A 1vhwC-5hmqA:
undetectable
1vhwE-5hmqA:
undetectable		 1vhwC-5hmqA:
17.30
1vhwE-5hmqA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		4 / 8 LEU A  97
SER A 206
VAL A 102
GLY A 139
 None
 1.07A 2qd5A-5hmqA:
2.8		 2qd5A-5hmqA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		4 / 8 LEU A  97
SER A 206
VAL A 102
GLY A 139
 None
 1.05A 2qd5B-5hmqA:
undetectable		 2qd5B-5hmqA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 LEU A 438
ILE A 339
ALA A 536
VAL A 533
HIS A 443
 None
None
None
None
MG  A 702 (-3.3A)
 1.40A 2qo4A-5hmqA:
undetectable		 2qo4A-5hmqA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		4 / 7 PHE A 464
PRO A 399
LEU A 376
ALA A 379
 None
 1.11A 2vcvA-5hmqA:
undetectable		 2vcvA-5hmqA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 10 GLU A 297
VAL A 303
ALA A 345
LEU A 334
ARG A 335
 None
 1.36A 3a3yA-5hmqA:
undetectable		 3a3yA-5hmqA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		4 / 7 ILE A 341
LEU A 315
PHE A 320
ARG A 440
 None
 1.02A 3ag4N-5hmqA:
undetectable
3ag4W-5hmqA:
undetectable		 3ag4N-5hmqA:
21.02
3ag4W-5hmqA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APT_B_ACTB311_0
(METHYLENETETRAHYDROF
OLATE REDUCTASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 9 GLU A 599
HIS A 443
ALA A 612
HIS A 586
TYR A 588
 MG  A 702 (-2.5A)
MG  A 702 (-3.3A)
None
None
None
 1.28A 3aptB-5hmqA:
4.2		 3aptB-5hmqA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		4 / 8 LEU A 261
MET A 220
ALA A 221
LEU A 224
 None
 0.78A 3cldB-5hmqA:
undetectable		 3cldB-5hmqA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 LEU A 376
LEU A 411
VAL A 401
PRO A 288
PRO A 287
 None
 1.07A 3dcjA-5hmqA:
undetectable
3dcjB-5hmqA:
undetectable		 3dcjA-5hmqA:
17.27
3dcjB-5hmqA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		4 / 5 ASP A 578
GLU A 583
GLY A 581
GLN A 580
 None
 1.26A 3w9tB-5hmqA:
undetectable		 3w9tB-5hmqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		4 / 5 LEU A 574
HIS A 443
GLU A 599
HIS A 521
 None
MG  A 702 (-3.3A)
MG  A 702 (-2.5A)
MG  A 702 (-3.5A)
 1.39A 4a7bB-5hmqA:
undetectable		 4a7bB-5hmqA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 ILE A 179
ILE A 182
GLY A 184
VAL A 148
GLY A 161
 None
 0.96A 4ac9B-5hmqA:
2.4
4ac9C-5hmqA:
undetectable		 4ac9B-5hmqA:
20.67
4ac9C-5hmqA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		4 / 7 LEU A 619
GLU A 599
HIS A 521
HIS A 520
 None
MG  A 702 (-2.5A)
MG  A 702 (-3.5A)
None
 1.24A 4aq7A-5hmqA:
undetectable		 4aq7A-5hmqA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 HIS A 521
TYR A 588
GLU A 599
HIS A 443
ASN A 498
 MG  A 702 (-3.5A)
None
MG  A 702 (-2.5A)
MG  A 702 (-3.3A)
None
 0.70A 4ir0A-5hmqA:
4.0
4ir0B-5hmqA:
5.6		 4ir0A-5hmqA:
11.77
4ir0B-5hmqA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 HIS A 443
ASN A 498
HIS A 521
TYR A 588
GLU A 599
 MG  A 702 (-3.3A)
None
MG  A 702 (-3.5A)
None
MG  A 702 (-2.5A)
 0.75A 4ir0A-5hmqA:
5.4
4ir0B-5hmqA:
5.6		 4ir0A-5hmqA:
11.77
4ir0B-5hmqA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 HIS A 521
TYR A 588
GLU A 599
HIS A 443
ASN A 498
 MG  A 702 (-3.5A)
None
MG  A 702 (-2.5A)
MG  A 702 (-3.3A)
None
 0.72A 4jd1A-5hmqA:
5.4
4jd1B-5hmqA:
3.8		 4jd1A-5hmqA:
11.77
4jd1B-5hmqA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 HIS A 443
ASN A 498
HIS A 521
TYR A 588
GLU A 599
 MG  A 702 (-3.3A)
None
MG  A 702 (-3.5A)
None
MG  A 702 (-2.5A)
 0.75A 4jd1A-5hmqA:
5.4
4jd1B-5hmqA:
3.8		 4jd1A-5hmqA:
11.77
4jd1B-5hmqA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 HIS A 521
TYR A 588
GLU A 599
HIS A 443
ASN A 498
 MG  A 702 (-3.5A)
None
MG  A 702 (-2.5A)
MG  A 702 (-3.3A)
None
 0.57A 4jh3A-5hmqA:
5.6
4jh3B-5hmqA:
3.8		 4jh3A-5hmqA:
11.80
4jh3B-5hmqA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 TYR A 588
GLU A 599
HIS A 443
ALA A 445
ASN A 498
 None
MG  A 702 (-2.5A)
MG  A 702 (-3.3A)
None
None
 1.29A 4jh3A-5hmqA:
5.6
4jh3B-5hmqA:
3.8		 4jh3A-5hmqA:
11.80
4jh3B-5hmqA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 HIS A 443
ASN A 498
HIS A 521
TYR A 588
GLU A 599
 MG  A 702 (-3.3A)
None
MG  A 702 (-3.5A)
None
MG  A 702 (-2.5A)
 0.55A 4jh3A-5hmqA:
5.6
4jh3B-5hmqA:
3.8		 4jh3A-5hmqA:
11.80
4jh3B-5hmqA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 HIS A 521
TYR A 588
GLU A 599
HIS A 443
ASN A 498
 MG  A 702 (-3.5A)
None
MG  A 702 (-2.5A)
MG  A 702 (-3.3A)
None
 0.59A 4jh4A-5hmqA:
3.8
4jh4B-5hmqA:
5.6		 4jh4A-5hmqA:
11.80
4jh4B-5hmqA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 TYR A 588
GLU A 599
HIS A 443
ALA A 445
ASN A 498
 None
MG  A 702 (-2.5A)
MG  A 702 (-3.3A)
None
None
 1.27A 4jh4A-5hmqA:
3.8
4jh4B-5hmqA:
5.6		 4jh4A-5hmqA:
11.80
4jh4B-5hmqA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 HIS A 443
ALA A 445
ASN A 498
TYR A 588
GLU A 599
 MG  A 702 (-3.3A)
None
None
None
MG  A 702 (-2.5A)
 1.26A 4jh4A-5hmqA:
3.8
4jh4B-5hmqA:
5.6		 4jh4A-5hmqA:
11.80
4jh4B-5hmqA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 HIS A 443
ASN A 498
HIS A 521
TYR A 588
GLU A 599
 MG  A 702 (-3.3A)
None
MG  A 702 (-3.5A)
None
MG  A 702 (-2.5A)
 0.59A 4jh4A-5hmqA:
3.8
4jh4B-5hmqA:
5.6		 4jh4A-5hmqA:
11.80
4jh4B-5hmqA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 HIS A 521
TYR A 588
GLU A 599
HIS A 443
ASN A 498
 MG  A 702 (-3.5A)
None
MG  A 702 (-2.5A)
MG  A 702 (-3.3A)
None
 0.59A 4jh5A-5hmqA:
3.8
4jh5B-5hmqA:
5.6		 4jh5A-5hmqA:
11.80
4jh5B-5hmqA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 TYR A 588
GLU A 599
HIS A 443
ALA A 445
ASN A 498
 None
MG  A 702 (-2.5A)
MG  A 702 (-3.3A)
None
None
 1.27A 4jh5A-5hmqA:
3.8
4jh5B-5hmqA:
5.6		 4jh5A-5hmqA:
11.80
4jh5B-5hmqA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 HIS A 443
ASN A 498
HIS A 521
TYR A 588
GLU A 599
 MG  A 702 (-3.3A)
None
MG  A 702 (-3.5A)
None
MG  A 702 (-2.5A)
 0.59A 4jh5A-5hmqA:
3.8
4jh5B-5hmqA:
5.6		 4jh5A-5hmqA:
11.80
4jh5B-5hmqA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		4 / 6 TYR A  39
VAL A  29
ILE A  57
LEU A  87
 None
 0.87A 4l1wB-5hmqA:
7.1		 4l1wB-5hmqA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 PRO A 249
ALA A 255
HIS A 358
LEU A 448
GLY A 518
 None
 1.20A 4l9qB-5hmqA:
undetectable		 4l9qB-5hmqA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		4 / 6 PHE A 597
HIS A 443
TYR A 588
GLU A 599
 None
MG  A 702 (-3.3A)
None
MG  A 702 (-2.5A)
 1.04A 4pahA-5hmqA:
undetectable		 4pahA-5hmqA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 GLN A 215
LEU A 261
SER A 260
ASN A 253
PHE A  26
 None
 1.38A 4qdcA-5hmqA:
undetectable		 4qdcA-5hmqA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 HIS A 521
HIS A 443
GLU A 599
LEU A 568
TYR A 588
 MG  A 702 (-3.5A)
MG  A 702 (-3.3A)
MG  A 702 (-2.5A)
None
None
 1.24A 4r7lA-5hmqA:
undetectable		 4r7lA-5hmqA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 LEU A  97
PHE A 241
GLU A  30
LEU A  59
SER A 237
 None
 1.48A 4r88D-5hmqA:
6.2		 4r88D-5hmqA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 LEU A  97
PHE A 241
GLU A  30
LEU A  59
SER A 237
 None
 1.48A 4r88F-5hmqA:
5.2		 4r88F-5hmqA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		3 / 3 ASP A 175
ARG A 180
PRO A 226
 None
 0.97A 4wanC-5hmqA:
undetectable		 4wanC-5hmqA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 9 ARG A 118
ALA A 155
LEU A 160
GLY A 121
PHE A 223
 None
 1.50A 4y28A-5hmqA:
undetectable
4y28J-5hmqA:
undetectable		 4y28A-5hmqA:
22.64
4y28J-5hmqA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 10 ALA A 612
ARG A 618
HIS A 520
TYR A 588
HIS A 586
 None
 1.47A 5eb5B-5hmqA:
undetectable		 5eb5B-5hmqA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 MET A   1
VAL A 283
ILE A 227
LEU A 236
LEU A 264
 None
 1.25A 5im2A-5hmqA:
undetectable		 5im2A-5hmqA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		3 / 3 ASP A 109
ASN A 150
GLN A 154
 None
 0.77A 5k7uA-5hmqA:
undetectable		 5k7uA-5hmqA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		4 / 8 ARG A 310
GLU A 593
GLY A 359
PRO A 360
 None
 1.06A 5kf8A-5hmqA:
1.3		 5kf8A-5hmqA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		4 / 8 ARG A 310
GLU A 593
GLY A 359
PRO A 360
 None
 1.01A 5kgpA-5hmqA:
undetectable		 5kgpA-5hmqA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		4 / 8 ARG A 310
GLU A 593
GLY A 359
PRO A 360
 None
 1.03A 5kgpB-5hmqA:
undetectable		 5kgpB-5hmqA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		3 / 3 THR A 268
THR A 230
LEU A 164
 None
 0.69A 5m66D-5hmqA:
undetectable		 5m66D-5hmqA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		5 / 9 ALA A 523
ILE A 601
GLU A 599
PRO A 496
LEU A 584
 MG  A 702 ( 4.4A)
None
MG  A 702 (-2.5A)
None
None
 1.08A 5mvmA-5hmqA:
undetectable
5mvmE-5hmqA:
undetectable		 5mvmA-5hmqA:
8.84
5mvmE-5hmqA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
putida) 		4 / 6 ARG A 494
ALA A 445
PRO A 496
GLU A 599
 None
None
None
MG  A 702 (-2.5A)
 1.35A 5odqA-5hmqA:
undetectable		 5odqA-5hmqA:
21.50