SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hn4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A  82
ALA A 267
GLY A   9
GLY A  13
SER A 252
 None
 1.06A 1rjdA-5hn4A:
undetectable		 1rjdA-5hn4A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A  82
ALA A 267
GLY A   9
GLY A  13
SER A 252
 None
 1.05A 1rjdB-5hn4A:
undetectable		 1rjdB-5hn4A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A  82
ALA A 267
GLY A   9
GLY A  13
SER A 252
 None
 1.07A 1rjdC-5hn4A:
undetectable		 1rjdC-5hn4A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 ALA A 140
ILE A 143
ILE A 176
VAL A 180
ALA A 181
 None
 0.95A 1uduB-5hn4A:
undetectable		 1uduB-5hn4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A 215
ASN A 214
GLU A 115
LEU A 134
 None
 1.17A 2w8yA-5hn4A:
undetectable		 2w8yA-5hn4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 SER A 221
GLU A 247
ASP A 218
 None
48Y  A 401 ( 4.6A)
MN  A 402 ( 2.5A)
 0.61A 2zthA-5hn4A:
2.5		 2zthA-5hn4A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 MET A 325
GLU A 318
ASN A 295
 None
 0.96A 3a27A-5hn4A:
undetectable		 3a27A-5hn4A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 SER A 221
GLU A 247
ASP A 218
 None
48Y  A 401 ( 4.6A)
MN  A 402 ( 2.5A)
 0.60A 3bwmA-5hn4A:
undetectable		 3bwmA-5hn4A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 SER A 221
GLU A 247
ASP A 218
 None
48Y  A 401 ( 4.6A)
MN  A 402 ( 2.5A)
 0.62A 3bwyA-5hn4A:
undetectable		 3bwyA-5hn4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 10 PRO A 248
LEU A  65
ILE A  17
SER A 252
GLY A  13
 None
 1.19A 3ijxB-5hn4A:
undetectable
3ijxD-5hn4A:
undetectable		 3ijxB-5hn4A:
22.16
3ijxD-5hn4A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 10 PRO A 248
LEU A  65
ILE A  17
SER A 252
GLY A  13
 None
 1.16A 3iluB-5hn4A:
undetectable
3iluE-5hn4A:
undetectable		 3iluB-5hn4A:
22.16
3iluE-5hn4A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 11 ILE A  17
SER A 252
GLY A  13
PRO A 248
LEU A  65
 None
 1.16A 3iluB-5hn4A:
undetectable
3iluE-5hn4A:
undetectable		 3iluB-5hn4A:
22.16
3iluE-5hn4A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 VAL A  27
LEU A  65
ILE A 268
GLY A 271
ALA A 272
 None
 0.72A 3n8zB-5hn4A:
undetectable		 3n8zB-5hn4A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 TYR A  35
GLY A  67
GLY A   9
ALA A 267
LEU A  65
 None
 1.07A 3vywA-5hn4A:
undetectable		 3vywA-5hn4A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A  58
ILE A 243
ALA A 244
GLY A  67
ALA A   5
 None
 1.11A 4enhA-5hn4A:
undetectable		 4enhA-5hn4A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 PRO A 300
GLY A 304
GLY A 303
GLY A 314
PRO A 264
 None
 1.01A 4fp9A-5hn4A:
undetectable		 4fp9A-5hn4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 PRO A 300
GLY A 304
GLY A 303
GLY A 314
PRO A 264
 None
 1.01A 4fp9C-5hn4A:
undetectable		 4fp9C-5hn4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 PRO A 300
GLY A 304
GLY A 303
GLY A 314
PRO A 264
 None
 1.02A 4fp9D-5hn4A:
undetectable		 4fp9D-5hn4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 PRO A 300
GLY A 304
GLY A 303
GLY A 314
PRO A 264
 None
 1.01A 4fp9F-5hn4A:
undetectable		 4fp9F-5hn4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 PRO A 300
GLY A 304
GLY A 303
GLY A 314
PRO A 264
 None
 1.04A 4fzvA-5hn4A:
undetectable		 4fzvA-5hn4A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 ALA A  26
ILE A 319
GLY A 282
ILE A 285
VAL A  31
 None
 0.99A 4q5mA-5hn4A:
undetectable		 4q5mA-5hn4A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		4 / 7 PHE A 216
SER A 212
ALA A 164
LEU A 167
 None
 1.12A 4xk8A-5hn4A:
undetectable		 4xk8A-5hn4A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 SER A 221
GLU A 247
ASP A 218
 None
48Y  A 401 ( 4.6A)
MN  A 402 ( 2.5A)
 0.58A 4xudA-5hn4A:
3.0		 4xudA-5hn4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 10 ILE A 315
ILE A 268
VAL A 311
GLU A  15
ASP A  18
 None
 1.24A 5lg3F-5hn4A:
undetectable		 5lg3F-5hn4A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		4 / 5 ILE A 135
PHE A 160
SER A 212
ALA A 140
 None
 1.00A 5msdA-5hn4A:
2.6		 5msdA-5hn4A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 9 VAL A 293
GLY A 291
ILE A  97
ARG A 102
ASP A 100
 None
 1.45A 6c2mC-5hn4A:
0.0		 6c2mC-5hn4A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5hn4 HOMOISOCITRATE
DEHYDROGENASE
(Thermococcus
kodakarensis) 		4 / 8 ILE A 315
ALA A  20
VAL A  21
ASP A 276
 None
 0.92A 6hu9a-5hn4A:
undetectable
6hu9e-5hn4A:
undetectable		 6hu9a-5hn4A:
21.04
6hu9e-5hn4A:
15.86