SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hns'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5hns NIEMANN-PICK C1
PROTEIN
(Homo
sapiens) 		4 / 7 PHE A 590
ALA A 449
ILE A 601
ILE A 563
 None
 0.94A 1oniD-5hnsA:
undetectable
1oniF-5hnsA:
undetectable		 1oniD-5hnsA:
21.49
1oniF-5hnsA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 5hns NIEMANN-PICK C1
PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 547
GLY A 432
PRO A 434
HIS A 510
HIS A 418
 None
 1.39A 1tmxA-5hnsA:
undetectable		 1tmxA-5hnsA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 5hns NIEMANN-PICK C1
PROTEIN
(Homo
sapiens) 		5 / 10 SER A 483
ILE A 563
ILE A 410
LEU A 446
ILE A 448
 None
 1.17A 2nnhB-5hnsA:
undetectable		 2nnhB-5hnsA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5hns NIEMANN-PICK C1
PROTEIN
(Homo
sapiens) 		3 / 3 SER A 491
THR A 536
PHE A 565
 None
NAG  A 710 ( 3.9A)
None
 0.77A 2x91A-5hnsA:
undetectable		 2x91A-5hnsA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_1
(SPERMIDINE SYNTHASE)		 5hns NIEMANN-PICK C1
PROTEIN
(Homo
sapiens) 		4 / 5 GLN A 438
GLN A 442
ASP A 496
ASP A 508
 NAG  A 709 (-4.0A)
NAG  A 708 (-3.4A)
None
None
 1.50A 3bwcB-5hnsA:
undetectable		 3bwcB-5hnsA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5hns NIEMANN-PICK C1
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 437
TYR A 509
LEU A 440
LEU A 547
HIS A 510
 None
 1.39A 3vn2A-5hnsA:
undetectable		 3vn2A-5hnsA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5hns NIEMANN-PICK C1
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 481
TYR A 487
VAL A 517
LEU A 435
LEU A 561
 None
 1.20A 4qztA-5hnsA:
undetectable		 4qztA-5hnsA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 5hns NIEMANN-PICK C1
PROTEIN
(Homo
sapiens) 		5 / 10 ALA A 427
VAL A 429
ASP A 428
TYR A 420
GLY A 426
 NAG  A 704 (-3.6A)
NAG  A 703 ( 4.7A)
NAG  A 704 (-4.6A)
None
None
 1.26A 4xp1A-5hnsA:
undetectable		 4xp1A-5hnsA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 5hns NIEMANN-PICK C1
PROTEIN
(Homo
sapiens) 		5 / 12 PHE A 513
LEU A 547
ASN A 557
VAL A 429
TYR A 420
 None
None
NAG  A 703 (-2.5A)
NAG  A 703 ( 4.7A)
None
 1.33A 5v1tA-5hnsA:
undetectable		 5v1tA-5hnsA:
21.33