SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ho9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 412
GLY A 394
ASN A 396
GLY A 305
ASP A 238
 None
None
None
None
AHR  A 720 ( 4.9A)
 1.29A 1ffyA-5ho9A:
undetectable		 1ffyA-5ho9A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLN A 477
TYR A 442
ARG A 443
 None
None
SO4  A 711 (-3.1A)
 0.70A 1gtbA-5ho9A:
undetectable		 1gtbA-5ho9A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A 354
VAL A 321
ILE A 260
GLY A 259
GLY A 298
 None
 1.05A 1k6cA-5ho9A:
undetectable		 1k6cA-5ho9A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 6 TRP A 221
GLY A 292
ASP A 288
TYR A 253
 None
 1.08A 1kf6M-5ho9A:
undetectable
1kf6N-5ho9A:
undetectable		 1kf6M-5ho9A:
22.35
1kf6N-5ho9A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 7 ALA A 354
ASP A 348
GLY A 344
THR A 306
 None
 0.82A 1t7iB-5ho9A:
undetectable		 1t7iB-5ho9A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 7 ALA A 354
ASP A 348
GLY A 344
THR A 306
 None
 0.80A 1t7jB-5ho9A:
undetectable		 1t7jB-5ho9A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 326
HIS A 412
THR A 322
ASP A 238
GLY A  69
 None
None
None
AHR  A 720 ( 4.9A)
None
 1.18A 1v8bA-5ho9A:
undetectable		 1v8bA-5ho9A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 326
HIS A 412
THR A 322
ASP A 238
GLY A  69
 None
None
None
AHR  A 720 ( 4.9A)
None
 1.16A 1v8bB-5ho9A:
undetectable		 1v8bB-5ho9A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 326
HIS A 412
THR A 322
ASP A 238
GLY A  69
 None
None
None
AHR  A 720 ( 4.9A)
None
 1.20A 1v8bD-5ho9A:
undetectable		 1v8bD-5ho9A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 8 PRO A 578
LEU A 565
GLY A 566
LEU A 563
 SO4  A 710 (-4.0A)
None
None
None
 0.95A 1ya4A-5ho9A:
undetectable		 1ya4A-5ho9A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 8 TYR A 332
ASN A 333
LYS A 368
GLY A 324
 None
 0.98A 1ykiA-5ho9A:
undetectable
1ykiB-5ho9A:
undetectable		 1ykiA-5ho9A:
15.49
1ykiB-5ho9A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 8 TYR A 332
ASN A 333
LYS A 368
GLY A 324
 None
 0.97A 1ykiC-5ho9A:
undetectable
1ykiD-5ho9A:
undetectable		 1ykiC-5ho9A:
15.49
1ykiD-5ho9A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 6 TYR A 253
ASP A 288
PHE A 233
ARG A 218
 None
 1.44A 2a3bB-5ho9A:
undetectable		 2a3bB-5ho9A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 8 ASP A 473
GLY A 330
TYR A 470
THR A 322
 None
 1.01A 2aouA-5ho9A:
undetectable		 2aouA-5ho9A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 6 PRO A 172
ILE A  72
ASN A 104
LEU A 105
 None
 1.23A 2wekB-5ho9A:
undetectable		 2wekB-5ho9A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 6 PRO A 172
ILE A 148
ASN A 104
LEU A 105
 None
 1.29A 2wekB-5ho9A:
undetectable		 2wekB-5ho9A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 326
HIS A 412
GLU A 304
ASP A 238
GLY A  69
 None
None
AHR  A 721 ( 3.8A)
AHR  A 720 ( 4.9A)
None
 1.36A 2zj0A-5ho9A:
undetectable		 2zj0A-5ho9A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 326
HIS A 412
GLU A 304
ASP A 238
GLY A  69
 None
None
AHR  A 721 ( 3.8A)
AHR  A 720 ( 4.9A)
None
 1.36A 3ce6A-5ho9A:
undetectable		 3ce6A-5ho9A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 326
HIS A 412
GLU A 304
ASP A 238
GLY A  69
 None
None
AHR  A 721 ( 3.8A)
AHR  A 720 ( 4.9A)
None
 1.38A 3ce6C-5ho9A:
undetectable		 3ce6C-5ho9A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 412
GLU A 304
THR A 322
ASP A 238
GLY A  69
 None
AHR  A 721 ( 3.8A)
None
AHR  A 720 ( 4.9A)
None
 1.38A 3ce6D-5ho9A:
undetectable		 3ce6D-5ho9A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASN A 333
ASP A 348
GLN A 352
 None
 0.84A 3eeyC-5ho9A:
undetectable		 3eeyC-5ho9A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASN A 333
ASP A 348
GLN A 352
 None
 0.83A 3eeyD-5ho9A:
undetectable		 3eeyD-5ho9A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASN A 333
ASP A 348
GLN A 352
 None
 0.82A 3eeyE-5ho9A:
undetectable		 3eeyE-5ho9A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 326
HIS A 412
THR A 322
ASP A 238
GLY A  69
 None
None
None
AHR  A 720 ( 4.9A)
None
 1.23A 3g1uD-5ho9A:
undetectable		 3g1uD-5ho9A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ASP A 361
TYR A 365
ASP A 348
GLY A 539
SER A 536
 None
 1.18A 3hiiA-5ho9A:
3.2		 3hiiA-5ho9A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ASP A 361
TYR A 365
ASP A 348
GLY A 539
SER A 536
 None
 1.18A 3hiiB-5ho9A:
undetectable		 3hiiB-5ho9A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 8 TYR A 323
PRO A 357
SER A 353
ASP A 348
 None
 1.12A 3lsfH-5ho9A:
undetectable		 3lsfH-5ho9A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 11 LEU A 208
ASN A 204
GLY A 162
ILE A 161
PRO A 272
 None
 1.15A 3spkA-5ho9A:
undetectable		 3spkA-5ho9A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A 208
ASN A 204
GLY A 162
ILE A 161
PRO A 272
 None
 1.15A 3spkA-5ho9A:
undetectable		 3spkA-5ho9A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 539
GLY A 366
GLN A 352
SER A 541
ALA A 349
 None
 1.18A 3sxjA-5ho9A:
undetectable		 3sxjA-5ho9A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 539
GLY A 366
GLN A 352
SER A 541
ALA A 349
 None
 1.18A 3sxjB-5ho9A:
undetectable		 3sxjB-5ho9A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 539
GLY A 366
GLN A 352
SER A 541
ALA A 349
 None
 1.26A 3t7sA-5ho9A:
undetectable		 3t7sA-5ho9A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 539
GLY A 366
GLN A 352
SER A 541
ALA A 349
 None
 1.25A 3t7sB-5ho9A:
undetectable		 3t7sB-5ho9A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 539
GLY A 366
GLN A 352
SER A 541
ALA A 349
 None
 1.27A 3t7sC-5ho9A:
undetectable		 3t7sC-5ho9A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 539
GLY A 366
GLN A 352
SER A 541
ALA A 349
 None
 1.29A 3t7sD-5ho9A:
undetectable		 3t7sD-5ho9A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 303
GLY A 297
LEU A 326
HIS A 395
GLY A 330
 None
 1.22A 4blvB-5ho9A:
undetectable		 4blvB-5ho9A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 7 PHE A 261
TYR A 253
ILE A 161
PRO A 234
 None
 1.15A 4g5jA-5ho9A:
undetectable		 4g5jA-5ho9A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 7 ASN A  82
VAL A 426
ARG A 425
ARG A 443
 None
None
SO4  A 711 ( 4.7A)
SO4  A 711 (-3.1A)
 1.12A 4ijiH-5ho9A:
undetectable		 4ijiH-5ho9A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A 283
TRP A 250
SER A 353
 None
 0.97A 4lrhA-5ho9A:
undetectable		 4lrhA-5ho9A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 TYR A 149
VAL A 180
ALA A 160
SER A 151
GLY A 162
 None
 1.11A 4mm8A-5ho9A:
undetectable		 4mm8A-5ho9A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 10 TYR A 149
VAL A 180
ALA A 160
SER A 151
GLY A 162
 None
 1.15A 4mmdA-5ho9A:
undetectable		 4mmdA-5ho9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 TYR A 149
VAL A 180
ALA A 160
SER A 151
GLY A 162
 None
 1.17A 4mmdB-5ho9A:
undetectable		 4mmdB-5ho9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 326
GLU A 304
THR A 322
ASP A 238
GLY A  69
 None
AHR  A 721 ( 3.8A)
None
AHR  A 720 ( 4.9A)
None
 1.02A 5m5kB-5ho9A:
undetectable		 5m5kB-5ho9A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 326
HIS A 412
THR A 322
ASP A 238
GLY A  69
 None
None
None
AHR  A 720 ( 4.9A)
None
 1.13A 5m5kB-5ho9A:
undetectable		 5m5kB-5ho9A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 326
HIS A 412
THR A 322
ASP A 238
GLY A  69
 None
None
None
AHR  A 720 ( 4.9A)
None
 1.15A 5m66A-5ho9A:
undetectable		 5m66A-5ho9A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLU A  73
HIS A  54
VAL A  53
 AHR  A 718 ( 3.0A)
AHR  A 719 ( 3.7A)
None
 0.93A 5trqB-5ho9A:
undetectable		 5trqB-5ho9A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 326
HIS A 412
THR A 322
ASP A 238
GLY A  69
 None
None
None
AHR  A 720 ( 4.9A)
None
 1.19A 5utuF-5ho9A:
undetectable		 5utuF-5ho9A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 7 SER A 541
GLY A 544
ALA A 531
VAL A 452
 None
 0.68A 6dwnB-5ho9A:
undetectable		 6dwnB-5ho9A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 5ho9 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 7 GLY A 305
HIS A 422
GLU A  73
GLY A  69
 None
AHR  A 718 ( 4.3A)
AHR  A 718 ( 3.0A)
None
 0.98A 6n7fA-5ho9A:
undetectable		 6n7fA-5ho9A:
9.49