SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hoe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 5hoe HYDROLASE
(Sinorhizobium
meliloti) 		4 / 4 GLY A  54
LEU A  55
GLY A  11
ARG A  58
 None
 1.46A 1j7kA-5hoeA:
undetectable		 1j7kA-5hoeA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hoe HYDROLASE
(Sinorhizobium
meliloti) 		3 / 3 VAL A 214
ALA A 211
HIS A 208
 None
 0.79A 1q23L-5hoeA:
undetectable		 1q23L-5hoeA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5hoe HYDROLASE
(Sinorhizobium
meliloti) 		4 / 7 ASP A 194
PHE A 152
PHE A 156
SER A  13
 None
None
None
PO4  A 301 (-2.5A)
 1.43A 1rqpB-5hoeA:
3.8		 1rqpB-5hoeA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 5hoe HYDROLASE
(Sinorhizobium
meliloti) 		4 / 7 THR A 190
ALA A  57
ASN A  96
PHE A 156
 None
PO4  A 301 (-4.0A)
PO4  A 301 (-3.0A)
None
 1.15A 2hzqA-5hoeA:
undetectable		 2hzqA-5hoeA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5hoe HYDROLASE
(Sinorhizobium
meliloti) 		5 / 10 GLY A 118
GLN A 119
MET A 113
VAL A 179
VAL A 136
 None
 1.16A 3fhjB-5hoeA:
undetectable		 3fhjB-5hoeA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5hoe HYDROLASE
(Sinorhizobium
meliloti) 		5 / 10 GLY A 118
GLN A 119
MET A 113
VAL A 179
VAL A 136
 None
 1.16A 3fhjC-5hoeA:
undetectable		 3fhjC-5hoeA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 5hoe HYDROLASE
(Sinorhizobium
meliloti) 		3 / 3 ARG A  35
VAL A  21
THR A  27
 None
 0.76A 3k4vD-5hoeA:
undetectable		 3k4vD-5hoeA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 5hoe HYDROLASE
(Sinorhizobium
meliloti) 		5 / 12 ASN A  96
ASP A  97
ASP A  64
MET A 155
ILE A 196
 PO4  A 301 (-3.0A)
None
None
None
PO4  A 301 (-4.6A)
 1.30A 3lpsA-5hoeA:
undetectable		 3lpsA-5hoeA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 5hoe HYDROLASE
(Sinorhizobium
meliloti) 		4 / 7 SER A  61
TYR A 170
MET A 113
ASP A  97
 None
 1.43A 3lslA-5hoeA:
undetectable
3lslD-5hoeA:
undetectable		 3lslA-5hoeA:
21.79
3lslD-5hoeA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 5hoe HYDROLASE
(Sinorhizobium
meliloti) 		3 / 3 ARG A  35
VAL A  21
THR A  27
 None
 0.70A 3ndtA-5hoeA:
undetectable		 3ndtA-5hoeA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5hoe HYDROLASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A  62
SER A  25
PHE A 156
PHE A 152
TYR A 101
 None
 1.36A 4amjB-5hoeA:
undetectable		 4amjB-5hoeA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5hoe HYDROLASE
(Sinorhizobium
meliloti) 		4 / 8 LEU A  44
ILE A  90
VAL A 139
GLY A 207
 None
 0.84A 4eq4B-5hoeA:
undetectable		 4eq4B-5hoeA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5hoe HYDROLASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 188
GLY A 185
ALA A 145
SER A  13
MET A  92
 None
None
None
PO4  A 301 (-2.5A)
None
 1.25A 5igvA-5hoeA:
undetectable		 5igvA-5hoeA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5hoe HYDROLASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 188
GLY A 185
ALA A 145
SER A  13
MET A  92
 None
None
None
PO4  A 301 (-2.5A)
None
 1.15A 5igyA-5hoeA:
undetectable		 5igyA-5hoeA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5hoe HYDROLASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 188
GLY A 185
ALA A 145
SER A  13
MET A  92
 None
None
None
PO4  A 301 (-2.5A)
None
 1.20A 5ih0A-5hoeA:
undetectable		 5ih0A-5hoeA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5hoe HYDROLASE
(Sinorhizobium
meliloti) 		4 / 8 ALA A 183
ILE A 210
ALA A 209
LEU A 206
 None
 0.81A 5te8B-5hoeA:
undetectable		 5te8B-5hoeA:
17.89