SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hon'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 5hon EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 7 PRO A 742
VAL A 741
THR A 722
LEU A 721
 None
 0.97A 1jgsA-5honA:
undetectable		 1jgsA-5honA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 5hon EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 10 LEU A 714
GLY A 694
PRO A 718
VAL A 716
ILE A 825
 None
 0.96A 1sdtA-5honA:
undetectable		 1sdtA-5honA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5hon EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 5 LEU A 714
PRO A 718
VAL A 716
ILE A 825
 None
 0.91A 2aoiB-5honA:
undetectable		 2aoiB-5honA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 5hon EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 6 PRO A 701
LEU A 828
ARG A 699
GLY A 697
 None
 1.26A 2hs2B-5honA:
undetectable		 2hs2B-5honA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5hon EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 767
THR A 769
LEU A 721
LEU A 714
THR A 727
 None
 1.09A 2jn3A-5honA:
undetectable		 2jn3A-5honA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 5hon EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 754
GLY A 730
ASP A 702
PHE A 810
PHE A 803
 None
 1.21A 3qowA-5honA:
undetectable		 3qowA-5honA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 5hon EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 10 VAL A 802
LEU A 828
ALA A 731
PHE A 729
THR A 727
 None
 1.44A 5mm4B-5honA:
undetectable		 5mm4B-5honA:
17.22