SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hp5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		3 / 3 TRP A 467
TYR A 578
LEU A 574
 None
 0.77A 1kxhA-5hp5A:
undetectable		 1kxhA-5hp5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		5 / 11 LEU A 554
VAL A 591
LEU A 492
LEU A 490
MET A 589
 None
 1.28A 1mx1B-5hp5A:
undetectable		 1mx1B-5hp5A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		4 / 7 VAL A 203
VAL A 287
CYH A 187
ARG A 212
 None
 1.24A 1t46A-5hp5A:
undetectable		 1t46A-5hp5A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		5 / 10 ALA A 292
ILE A 149
CYH A 154
ASP A 155
PHE A 256
 None
None
None
CA  A 702 ( 2.5A)
None
 1.26A 2b17A-5hp5A:
undetectable		 2b17A-5hp5A:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		3 / 3 LYS A 486
ASP A 548
ASP A 564
 None
 0.95A 2br4D-5hp5A:
undetectable		 2br4D-5hp5A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		3 / 3 LEU A 166
LEU A 171
MET A 172
 None
 0.83A 2itzA-5hp5A:
undetectable		 2itzA-5hp5A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		5 / 9 VAL A 265
GLY A 263
PRO A 257
THR A 255
GLY A 253
 None
 1.26A 3bjwG-5hp5A:
undetectable		 3bjwG-5hp5A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		5 / 12 TYR A 464
GLU A 475
VAL A 470
GLY A 471
HIS A 542
 None
 1.19A 3f8wB-5hp5A:
undetectable		 3f8wB-5hp5A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		4 / 6 LEU A 184
VAL A 272
VAL A 238
ILE A 117
 None
 1.07A 3k5vA-5hp5A:
undetectable		 3k5vA-5hp5A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		4 / 5 PHE A 502
ILE A 527
GLY A 603
CYH A 611
 None
 1.38A 3r0lD-5hp5A:
undetectable		 3r0lD-5hp5A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		5 / 12 TYR A 636
GLY A 641
ASP A 632
ILE A 568
PHE A 583
 None
 1.03A 3sudB-5hp5A:
undetectable		 3sudB-5hp5A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		3 / 3 PRO A 373
ASP A 371
GLU A 397
 None
CA  A 704 (-2.5A)
None
 0.86A 3v4tC-5hp5A:
undetectable		 3v4tC-5hp5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		4 / 6 HIS A 535
GLU A 580
ASP A 585
ASP A 539
 None
 1.38A 4blvA-5hp5A:
undetectable		 4blvA-5hp5A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		5 / 12 LEU A 452
LEU A 412
ARG A 396
THR A 297
VAL A 394
 None
 1.26A 4f4dA-5hp5A:
undetectable		 4f4dA-5hp5A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		4 / 8 ASP A 258
GLN A 455
VAL A 394
THR A 395
 None
 1.16A 4lnwA-5hp5A:
undetectable		 4lnwA-5hp5A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA305_0
(THAUMATIN-1)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		4 / 5 GLU A 305
ILE A 386
PHE A 391
VAL A 369
 None
 1.35A 4tvtA-5hp5A:
undetectable		 4tvtA-5hp5A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		5 / 12 ALA A 104
LEU A 105
PRO A  34
ARG A  67
LEU A   9
 None
 1.07A 5ljcA-5hp5A:
undetectable		 5ljcA-5hp5A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		4 / 5 VAL A 457
PRO A 426
GLY A 428
TYR A 425
 None
 1.17A 5x80A-5hp5A:
undetectable
5x80B-5hp5A:
undetectable		 5x80A-5hp5A:
15.77
5x80B-5hp5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		4 / 5 PRO A 426
GLY A 428
TYR A 425
VAL A 457
 None
 1.16A 5x80C-5hp5A:
undetectable
5x80D-5hp5A:
undetectable		 5x80C-5hp5A:
15.77
5x80D-5hp5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		4 / 5 VAL A 280
THR A 276
VAL A 115
LEU A 199
 None
 0.99A 6bqgA-5hp5A:
undetectable		 6bqgA-5hp5A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		4 / 7 TRP A 349
SER A 405
HIS A 472
GLY A 471
 None
 1.15A 6btxA-5hp5A:
undetectable		 6btxA-5hp5A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		5 / 10 SER A  43
LEU A   9
SER A 108
ILE A  29
SER A  95
 None
 1.34A 6dlzB-5hp5A:
undetectable
6dlzC-5hp5A:
undetectable		 6dlzB-5hp5A:
8.24
6dlzC-5hp5A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		5 / 11 ILE A  29
SER A  95
SER A  43
LEU A   9
SER A 108
 None
 1.34A 6dlzA-5hp5A:
undetectable
6dlzD-5hp5A:
undetectable		 6dlzA-5hp5A:
8.24
6dlzD-5hp5A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		5 / 10 SER A  43
LEU A   9
SER A 108
ILE A  29
SER A  95
 None
 1.34A 6dm1B-5hp5A:
undetectable
6dm1C-5hp5A:
undetectable		 6dm1B-5hp5A:
8.24
6dm1C-5hp5A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		5 / 11 ILE A  29
SER A  95
SER A  43
LEU A   9
SER A 108
 None
 1.33A 6dm1A-5hp5A:
undetectable
6dm1D-5hp5A:
undetectable		 6dm1A-5hp5A:
8.24
6dm1D-5hp5A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		3 / 3 PHE A 370
ARG A 396
ALA A 454
 None
 0.73A 6ecfB-5hp5A:
undetectable		 6ecfB-5hp5A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		3 / 3 ASP A 352
ASP A 585
ASN A 540
 None
 0.78A 6gngB-5hp5A:
undetectable		 6gngB-5hp5A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens) 		4 / 7 HIS A 637
HIS A 472
GLU A 642
ASP A 585
 None
 1.34A 6mn4F-5hp5A:
undetectable		 6mn4F-5hp5A:
19.07