SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hp6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 412
GLY A 394
ASN A 396
GLY A 305
ASP A 238
 None
None
None
CA  A 902 ( 4.5A)
TRS  A 903 (-2.7A)
 1.30A 1ffyA-5hp6A:
undetectable		 1ffyA-5hp6A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLN A 477
TYR A 442
ARG A 443
 None
 0.70A 1gtbA-5hp6A:
undetectable		 1gtbA-5hp6A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 7 PRO A 742
VAL A 741
THR A 722
LEU A 721
 None
 0.99A 1jgsA-5hp6A:
undetectable		 1jgsA-5hp6A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 6 TRP A 221
GLY A 292
ASP A 288
TYR A 253
 None
 1.05A 1kf6M-5hp6A:
undetectable
1kf6N-5hp6A:
undetectable		 1kf6M-5hp6A:
21.18
1kf6N-5hp6A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 412
VAL A 410
VAL A 424
ALA A  74
ALA A  75
 None
 1.11A 1likA-5hp6A:
undetectable		 1likA-5hp6A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A 346
ILE A 293
PHE A 242
ALA A 252
 None
 1.14A 1oniD-5hp6A:
undetectable
1oniE-5hp6A:
undetectable		 1oniD-5hp6A:
11.41
1oniE-5hp6A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 10 LEU A 714
GLY A 694
PRO A 718
VAL A 716
ILE A 825
 None
 0.96A 1sdtA-5hp6A:
undetectable		 1sdtA-5hp6A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 326
HIS A 412
THR A 322
ASP A 238
GLY A  69
 TRS  A 903 (-4.4A)
None
None
TRS  A 903 (-2.7A)
None
 1.22A 1v8bA-5hp6A:
undetectable		 1v8bA-5hp6A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 326
HIS A 412
THR A 322
ASP A 238
GLY A  69
 TRS  A 903 (-4.4A)
None
None
TRS  A 903 (-2.7A)
None
 1.21A 1v8bB-5hp6A:
undetectable		 1v8bB-5hp6A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 326
HIS A 412
THR A 322
ASP A 238
GLY A  69
 TRS  A 903 (-4.4A)
None
None
TRS  A 903 (-2.7A)
None
 1.24A 1v8bD-5hp6A:
undetectable		 1v8bD-5hp6A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 TYR A 228
GLY A 254
GLY A 259
ILE A 295
ILE A 237
 None
None
None
None
TRS  A 903 (-4.4A)
 1.09A 1x1aA-5hp6A:
undetectable		 1x1aA-5hp6A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 8 PRO A 578
LEU A 565
GLY A 566
LEU A 563
 None
 0.92A 1ya4A-5hp6A:
undetectable		 1ya4A-5hp6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 6 TYR A 253
ASP A 288
PHE A 233
ARG A 218
 None
 1.45A 2a3bB-5hp6A:
undetectable		 2a3bB-5hp6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 5 LEU A 714
PRO A 718
VAL A 716
ILE A 825
 None
 0.89A 2aoiB-5hp6A:
undetectable		 2aoiB-5hp6A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A 438
ILE A 508
ILE A 506
VAL A 480
PHE A 532
 None
 1.20A 2ft9A-5hp6A:
undetectable		 2ft9A-5hp6A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 767
THR A 769
LEU A 721
LEU A 714
THR A 727
 None
 1.00A 2jn3A-5hp6A:
undetectable		 2jn3A-5hp6A:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A 290
TYR A 228
TYR A 253
ILE A 161
 None
 1.34A 2ph9A-5hp6A:
undetectable
2ph9B-5hp6A:
undetectable		 2ph9A-5hp6A:
13.33
2ph9B-5hp6A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 6 PRO A 172
ILE A 148
ASN A 104
LEU A 105
 None
 1.31A 2wekB-5hp6A:
undetectable		 2wekB-5hp6A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 326
HIS A 412
GLU A 304
ASP A 238
GLY A  69
 TRS  A 903 (-4.4A)
None
TRS  A 903 (-2.9A)
TRS  A 903 (-2.7A)
None
 1.46A 3ce6C-5hp6A:
undetectable		 3ce6C-5hp6A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 412
GLU A 304
THR A 322
ASP A 238
GLY A  69
 None
TRS  A 903 (-2.9A)
None
TRS  A 903 (-2.7A)
None
 1.46A 3ce6D-5hp6A:
undetectable		 3ce6D-5hp6A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 305
ASP A 238
SER A  70
HIS A  71
ALA A 127
 CA  A 902 ( 4.5A)
TRS  A 903 (-2.7A)
TRS  A 903 ( 4.0A)
None
TRS  A 903 ( 4.5A)
 1.29A 3d91A-5hp6A:
undetectable		 3d91A-5hp6A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 326
HIS A 412
THR A 322
ASP A 238
GLY A  69
 TRS  A 903 (-4.4A)
None
None
TRS  A 903 (-2.7A)
None
 1.27A 3g1uD-5hp6A:
undetectable		 3g1uD-5hp6A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ASP A 361
TYR A 365
ASP A 348
GLY A 539
SER A 536
 None
 1.34A 3hiiB-5hp6A:
1.9		 3hiiB-5hp6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 646
LEU A 828
LEU A 700
PHE A 810
SER A 809
 None
 1.21A 3hj3C-5hp6A:
undetectable		 3hj3C-5hp6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ASN A 229
GLY A 297
VAL A 321
ASN A 235
GLU A 304
 None
None
None
None
TRS  A 903 (-2.9A)
 1.43A 3jb2A-5hp6A:
undetectable		 3jb2A-5hp6A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 628
THR A 627
ALA A 626
ALA A 560
SER A 588
 None
 0.89A 3mg0Y-5hp6A:
undetectable
3mg0Z-5hp6A:
undetectable		 3mg0Y-5hp6A:
14.59
3mg0Z-5hp6A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 754
GLY A 730
ASP A 702
PHE A 810
PHE A 803
 None
 1.25A 3qowA-5hp6A:
undetectable		 3qowA-5hp6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 11 LEU A 535
SER A 536
ASN A 367
GLY A 366
ASP A 348
 None
 1.37A 3sfuC-5hp6A:
undetectable		 3sfuC-5hp6A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 11 LEU A 208
ASN A 204
GLY A 162
ILE A 161
PRO A 272
 None
 1.10A 3spkA-5hp6A:
undetectable		 3spkA-5hp6A:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A 208
ASN A 204
GLY A 162
ILE A 161
PRO A 272
 None
 1.10A 3spkA-5hp6A:
undetectable		 3spkA-5hp6A:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 6 TYR A 332
GLY A 394
HIS A  54
THR A 413
 None
None
TRS  A 903 (-4.4A)
None
 1.00A 3tj7A-5hp6A:
undetectable
3tj7B-5hp6A:
undetectable		 3tj7A-5hp6A:
13.21
3tj7B-5hp6A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 6 TYR A 332
GLY A 394
HIS A  54
THR A 413
 None
None
TRS  A 903 (-4.4A)
None
 1.00A 3tj7C-5hp6A:
undetectable
3tj7D-5hp6A:
undetectable		 3tj7C-5hp6A:
13.21
3tj7D-5hp6A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 6 HIS A  54
THR A 413
TYR A 332
GLY A 394
 TRS  A 903 (-4.4A)
None
None
None
 1.02A 3tj7C-5hp6A:
undetectable
3tj7D-5hp6A:
undetectable		 3tj7C-5hp6A:
13.21
3tj7D-5hp6A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 5 GLU A 832
GLY A 833
TYR A 831
GLN A 839
 None
 1.48A 3w9tD-5hp6A:
undetectable		 3w9tD-5hp6A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 697
GLN A 695
ASN A 693
LEU A 812
VAL A 814
 None
 1.16A 4azwA-5hp6A:
undetectable		 4azwA-5hp6A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 303
GLY A 297
LEU A 326
HIS A 395
GLY A 330
 None
None
TRS  A 903 (-4.4A)
CA  A 902 ( 3.7A)
None
 1.24A 4blvB-5hp6A:
undetectable		 4blvB-5hp6A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 11 VAL A 802
ALA A 808
PHE A 728
SER A 739
LEU A 751
 None
 1.45A 4eilA-5hp6A:
undetectable		 4eilA-5hp6A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 11 VAL A 802
ALA A 808
PHE A 728
SER A 739
LEU A 751
 None
 1.43A 4eilC-5hp6A:
undetectable		 4eilC-5hp6A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 11 VAL A 802
ALA A 808
PHE A 728
SER A 739
LEU A 751
 None
 1.42A 4eilE-5hp6A:
undetectable		 4eilE-5hp6A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 10 VAL A 802
ALA A 808
PHE A 728
SER A 739
LEU A 751
 None
 1.45A 4eilG-5hp6A:
undetectable		 4eilG-5hp6A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 7 PHE A 261
TYR A 253
ILE A 161
PRO A 234
 None
 1.16A 4g5jA-5hp6A:
undetectable		 4g5jA-5hp6A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A 825
LEU A 828
PHE A 728
GLY A 730
 None
 1.08A 4hbfA-5hp6A:
undetectable		 4hbfA-5hp6A:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 7 ASN A  82
VAL A 426
ARG A 425
ARG A 443
 None
 1.05A 4ijiH-5hp6A:
undetectable		 4ijiH-5hp6A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A 283
TRP A 250
SER A 353
 None
 1.07A 4lrhA-5hp6A:
undetectable		 4lrhA-5hp6A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ASP A 473
ALA A 328
VAL A 391
SER A 471
GLY A 330
 None
 1.31A 4mm4B-5hp6A:
undetectable		 4mm4B-5hp6A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 10 TYR A 149
VAL A 180
ALA A 160
SER A 151
GLY A 162
 None
 1.26A 4mmdA-5hp6A:
undetectable		 4mmdA-5hp6A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 646
GLY A 663
ALA A 808
GLY A 703
GLU A 832
 None
 1.19A 4r29C-5hp6A:
undetectable		 4r29C-5hp6A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 4 TYR A 390
THR A 413
GLY A 394
LEU A 409
 None
 0.96A 4w5nA-5hp6A:
undetectable		 4w5nA-5hp6A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 6 HIS A 412
PRO A 393
MET A 334
LEU A 326
 None
None
None
TRS  A 903 (-4.4A)
 1.46A 5dzka-5hp6A:
undetectable
5dzko-5hp6A:
undetectable		 5dzka-5hp6A:
14.05
5dzko-5hp6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 835
ALA A 776
ILE A 698
ARG A 829
ILE A 830
 None
 1.12A 5h8tA-5hp6A:
undetectable		 5h8tA-5hp6A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 775
THR A 722
ASP A 818
LEU A 714
 None
 0.97A 5jq7B-5hp6A:
undetectable		 5jq7B-5hp6A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 326
GLU A 304
THR A 322
ASP A 238
GLY A  69
 TRS  A 903 (-4.4A)
TRS  A 903 (-2.9A)
None
TRS  A 903 (-2.7A)
None
 1.12A 5m5kB-5hp6A:
undetectable		 5m5kB-5hp6A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 326
HIS A 412
THR A 322
ASP A 238
GLY A  69
 TRS  A 903 (-4.4A)
None
None
TRS  A 903 (-2.7A)
None
 1.19A 5m5kB-5hp6A:
undetectable		 5m5kB-5hp6A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 326
HIS A 412
THR A 322
ASP A 238
GLY A  69
 TRS  A 903 (-4.4A)
None
None
TRS  A 903 (-2.7A)
None
 1.19A 5m66A-5hp6A:
undetectable		 5m66A-5hp6A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 10 VAL A 802
LEU A 828
ALA A 731
PHE A 729
THR A 727
 None
 1.42A 5mm4B-5hp6A:
undetectable		 5mm4B-5hp6A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hp6 EXTRACELLULAR
ARABINANASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 326
HIS A 412
THR A 322
ASP A 238
GLY A  69
 TRS  A 903 (-4.4A)
None
None
TRS  A 903 (-2.7A)
None
 1.24A 5utuF-5hp6A:
undetectable		 5utuF-5hp6A:
20.64