SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hph'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 537
LEU A 536
SER A 549
LEU A 500
 None
 0.85A 1j8uA-5hphA:
undetectable		 1j8uA-5hphA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 253
ILE A 255
LEU A 116
VAL A 211
ILE A 143
 None
 0.98A 2nnhA-5hphA:
undetectable		 2nnhA-5hphA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 411
ILE A 379
LEU A 405
ASN A 399
VAL A 391
 None
 1.02A 2nnhA-5hphA:
undetectable		 2nnhA-5hphA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_B_SALB104_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 VAL A 211
ARG A 269
VAL A 270
ILE A 113
ILE A 154
 None
 0.90A 3hgxB-5hphA:
0.9		 3hgxB-5hphA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 162
ILE A 241
PHE A 209
PHE A 205
 ANP  A 801 ( 4.3A)
None
None
None
 0.97A 3ko0B-5hphA:
undetectable
3ko0J-5hphA:
undetectable		 3ko0B-5hphA:
11.24
3ko0J-5hphA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 162
ILE A 241
PHE A 209
PHE A 205
 ANP  A 801 ( 4.3A)
None
None
None
 0.94A 3ko0K-5hphA:
undetectable
3ko0S-5hphA:
undetectable		 3ko0K-5hphA:
11.24
3ko0S-5hphA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 TYR A 366
LEU A 295
TYR A 317
PHE A 314
 None
 1.26A 3po7A-5hphA:
undetectable		 3po7A-5hphA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 VAL A 211
ARG A 269
VAL A 270
ILE A 154
 None
 0.82A 3remA-5hphA:
undetectable		 3remA-5hphA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 VAL A 211
ARG A 269
VAL A 270
ILE A 154
 None
 0.83A 3remB-5hphA:
undetectable		 3remB-5hphA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLU A 442
PHE A 441
ARG A 326
TYR A 444
 None
 1.45A 4uciA-5hphA:
undetectable		 4uciA-5hphA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLU A 442
PHE A 441
ARG A 326
TYR A 444
 None
 1.45A 4uciB-5hphA:
undetectable		 4uciB-5hphA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 THR A 249
GLY A 160
GLU A 142
HIS A 144
 None
 1.07A 5c0oH-5hphA:
undetectable		 5c0oH-5hphA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 SER A 221
THR A 164
GLU A 167
PRO A 139
LEU A 131
 None
 1.27A 5jh7D-5hphA:
undetectable		 5jh7D-5hphA:
21.78