SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hpi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR
(Acinetobacter
sp.
ADP1) 		4 / 5 THR A 200
THR A 196
THR A 187
HIS A 157
 None
 1.34A 1d4fB-5hpiA:
undetectable		 1d4fB-5hpiA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR
(Acinetobacter
sp.
ADP1) 		4 / 7 LEU A 260
ALA A 224
LEU A 238
THR A 161
 None
None
None
3HB  A 301 (-3.6A)
 1.03A 1dvxA-5hpiA:
undetectable		 1dvxA-5hpiA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR
(Acinetobacter
sp.
ADP1) 		4 / 7 LEU A 260
ALA A 224
LEU A 238
THR A 161
 None
None
None
3HB  A 301 (-3.6A)
 1.02A 1dvxB-5hpiA:
undetectable		 1dvxB-5hpiA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR
(Acinetobacter
sp.
ADP1) 		4 / 6 LEU A 260
ALA A 224
LEU A 238
THR A 161
 None
None
None
3HB  A 301 (-3.6A)
 1.00A 1tyrA-5hpiA:
undetectable		 1tyrA-5hpiA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR
(Acinetobacter
sp.
ADP1) 		4 / 6 LEU A 260
ALA A 224
LEU A 238
THR A 161
 None
None
None
3HB  A 301 (-3.6A)
 1.07A 3cfqA-5hpiA:
undetectable		 3cfqA-5hpiA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR
(Acinetobacter
sp.
ADP1) 		5 / 12 ALA A 222
GLY A 162
ILE A 223
SER A 212
LEU A 211
 3HB  A 301 (-3.2A)
None
None
3HB  A 301 ( 3.9A)
None
 1.27A 3gyqA-5hpiA:
undetectable
3gyqB-5hpiA:
undetectable		 3gyqA-5hpiA:
21.17
3gyqB-5hpiA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR
(Acinetobacter
sp.
ADP1) 		4 / 6 LEU A 260
ALA A 224
LEU A 238
THR A 161
 None
None
None
3HB  A 301 (-3.6A)
 0.99A 4d7bB-5hpiA:
undetectable		 4d7bB-5hpiA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR
(Acinetobacter
sp.
ADP1) 		4 / 8 ASN A 107
SER A 133
LEU A 135
ARG A 142
 None
 1.11A 4ijiF-5hpiA:
undetectable		 4ijiF-5hpiA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR
(Acinetobacter
sp.
ADP1) 		4 / 6 LEU A 260
ALA A 224
LEU A 238
THR A 161
 None
None
None
3HB  A 301 (-3.6A)
 1.00A 4ikiB-5hpiA:
undetectable		 4ikiB-5hpiA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR
(Acinetobacter
sp.
ADP1) 		4 / 7 LEU A 260
ALA A 224
LEU A 238
THR A 161
 None
None
None
3HB  A 301 (-3.6A)
 0.99A 4iklA-5hpiA:
undetectable
4iklB-5hpiA:
undetectable		 4iklA-5hpiA:
20.22
4iklB-5hpiA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR
(Acinetobacter
sp.
ADP1) 		4 / 8 LEU A 260
ALA A 224
LEU A 238
THR A 161
 None
None
None
3HB  A 301 (-3.6A)
 0.99A 4iklA-5hpiA:
undetectable
4iklB-5hpiA:
undetectable		 4iklA-5hpiA:
20.22
4iklB-5hpiA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR
(Acinetobacter
sp.
ADP1) 		3 / 3 LEU A 238
MET A 241
TYR A 209
 None
3HB  A 301 (-3.5A)
None
 0.92A 4p6xG-5hpiA:
undetectable		 4p6xG-5hpiA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR
(Acinetobacter
sp.
ADP1) 		4 / 7 LEU A 260
ALA A 224
LEU A 238
THR A 161
 None
None
None
3HB  A 301 (-3.6A)
 0.98A 4pwjB-5hpiA:
undetectable		 4pwjB-5hpiA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR
(Acinetobacter
sp.
ADP1) 		4 / 7 LEU A 260
ALA A 224
LEU A 238
THR A 161
 None
None
None
3HB  A 301 (-3.6A)
 1.02A 5bojB-5hpiA:
undetectable		 5bojB-5hpiA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR
(Acinetobacter
sp.
ADP1) 		4 / 6 LEU A 260
ALA A 224
LEU A 238
THR A 161
 None
None
None
3HB  A 301 (-3.6A)
 1.05A 5l4iB-5hpiA:
undetectable		 5l4iB-5hpiA:
20.22