SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hpk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
(Homo
sapiens) 		3 / 3 ASP A 728
GLU A 829
ARG A 877
 None
 0.81A 1wopA-5hpkA:
undetectable		 1wopA-5hpkA:
21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FCN_A_DVAA35_0
(UBIQUITIN)		 5hpk UBIQUITIN VARIANT
NL.1
(Homo
sapiens) 		4 / 4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 1.01A 2fcnA-5hpkB:
15.7		 2fcnA-5hpkB:
73.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FCN_B_DVAB35_0
(UBIQUITIN)		 5hpk UBIQUITIN VARIANT
NL.1
(Homo
sapiens) 		4 / 6 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 0.51A 2fcnA-5hpkB:
15.7
2fcnB-5hpkB:
15.5		 2fcnA-5hpkB:
73.81
2fcnB-5hpkB:
73.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
(Homo
sapiens) 		4 / 5 PHE A 893
PHE A 905
PHE A 863
VAL A 838
 None
 1.20A 2lh6A-5hpkA:
undetectable		 2lh6A-5hpkA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
(Homo
sapiens) 		4 / 7 GLY A 698
PHE A 807
ILE A 693
PHE A 715
 None
 1.03A 2qmzA-5hpkA:
undetectable
2qmzB-5hpkA:
undetectable		 2qmzA-5hpkA:
19.53
2qmzB-5hpkA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
(Homo
sapiens) 		4 / 8 PHE A 811
PHE A 807
PHE A 711
MET A 655
 None
 0.99A 2qwxA-5hpkA:
undetectable
2qwxB-5hpkA:
undetectable		 2qwxA-5hpkA:
19.53
2qwxB-5hpkA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
(Homo
sapiens) 		4 / 6 ILE A 675
ILE A 792
PHE A 711
MET A 718
 None
 1.16A 3adsA-5hpkA:
undetectable		 3adsA-5hpkA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
(Homo
sapiens) 		4 / 5 MET A 832
PHE A 577
PHE A 584
PHE A 823
 None
 1.28A 3ko0F-5hpkA:
undetectable
3ko0G-5hpkA:
undetectable		 3ko0F-5hpkA:
15.14
3ko0G-5hpkA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
(Homo
sapiens) 		5 / 9 LEU A 673
PHE A 711
THR A 885
LEU A 650
GLY A 709
 None
 1.45A 3nxuB-5hpkA:
undetectable		 3nxuB-5hpkA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
(Homo
sapiens) 		4 / 6 GLU A 609
TYR A 689
HIS A 686
PHE A 608
 None
 1.20A 4a97E-5hpkA:
undetectable		 4a97E-5hpkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
UBIQUITIN VARIANT
NL.1
(Homo
sapiens) 		4 / 5 GLU B  77
GLU A 609
TYR A 689
HIS A 686
 None
 1.43A 4a97J-5hpkB:
undetectable		 4a97J-5hpkB:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
(Homo
sapiens) 		4 / 8 GLU A 786
ILE A 777
ILE A 757
LEU A 753
 None
 0.79A 4mj8A-5hpkA:
undetectable		 4mj8A-5hpkA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
(Homo
sapiens) 		5 / 12 GLY A 698
ALA A 697
GLY A 694
MET A 804
LEU A 808
 None
 0.96A 4o33A-5hpkA:
undetectable		 4o33A-5hpkA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
(Homo
sapiens) 		5 / 12 GLY A 698
ALA A 697
GLY A 694
MET A 804
LEU A 808
 None
 0.94A 4o3fA-5hpkA:
undetectable		 4o3fA-5hpkA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
UBIQUITIN VARIANT
NL.1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG B   6
GLU A 664
TYR B  68
 None
 0.63A 4r29D-5hpkB:
undetectable		 4r29D-5hpkB:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
UBIQUITIN VARIANT
NL.1
(Homo
sapiens) 		4 / 7 GLU A 654
TYR A 660
LEU B  73
PHE A 608
 None
 1.18A 4twdF-5hpkA:
undetectable
4twdJ-5hpkA:
undetectable		 4twdF-5hpkA:
21.95
4twdJ-5hpkA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
UBIQUITIN VARIANT
NL.1
(Homo
sapiens) 		4 / 6 GLU A 654
TYR A 660
LEU B  73
PHE A 608
 None
 1.15A 4twdF-5hpkA:
undetectable
4twdG-5hpkA:
undetectable		 4twdF-5hpkA:
21.95
4twdG-5hpkA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
UBIQUITIN VARIANT
NL.1
(Homo
sapiens) 		4 / 6 GLU A 654
TYR A 660
LEU B  73
PHE A 608
 None
 1.10A 4twdI-5hpkA:
undetectable
4twdJ-5hpkA:
undetectable		 4twdI-5hpkA:
21.95
4twdJ-5hpkA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
(Homo
sapiens) 		3 / 3 LYS A 865
LEU A 869
ARG A 938
 None
 0.80A 5yw0A-5hpkA:
undetectable		 5yw0A-5hpkA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
(Homo
sapiens) 		4 / 7 PHE A 584
GLY A 698
LEU A 706
GLY A 834
 None
 0.70A 6eu9D-5hpkA:
undetectable		 6eu9D-5hpkA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
(Homo
sapiens) 		3 / 3 PHE A 923
ARG A 925
GLN A 903
 None
 0.98A 6g1pB-5hpkA:
undetectable		 6g1pB-5hpkA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
(Homo
sapiens) 		3 / 3 ILE A 724
THR A 725
PRO A 714
 None
 0.59A 6ncsA-5hpkA:
undetectable		 6ncsA-5hpkA:
19.69