SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hpl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hpl RSP5
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 435
LEU A 687
VAL A 556
PHE A 667
ALA A 447
 None
 1.29A 1q23A-5hplA:
undetectable
1q23B-5hplA:
undetectable		 1q23A-5hplA:
18.95
1q23B-5hplA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5hpl RSP5
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 685
GLY A 689
THR A 740
PHE A 565
 None
 1.05A 1ykiA-5hplA:
undetectable
1ykiB-5hplA:
undetectable		 1ykiA-5hplA:
21.67
1ykiB-5hplA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5hpl RSP5
(Saccharomyces
cerevisiae) 		4 / 8 THR A 740
PHE A 565
GLU A 685
GLY A 689
 None
 1.07A 1ykiA-5hplA:
undetectable
1ykiB-5hplA:
undetectable		 1ykiA-5hplA:
21.67
1ykiB-5hplA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5hpl RSP5
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 685
GLY A 689
THR A 740
PHE A 565
 None
 1.05A 1ykiC-5hplA:
undetectable
1ykiD-5hplA:
undetectable		 1ykiC-5hplA:
21.67
1ykiD-5hplA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5hpl RSP5
(Saccharomyces
cerevisiae) 		4 / 8 THR A 740
PHE A 565
GLU A 685
GLY A 689
 None
 1.08A 1ykiC-5hplA:
undetectable
1ykiD-5hplA:
undetectable		 1ykiC-5hplA:
21.67
1ykiD-5hplA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5hpl RSP5
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 507
ILE A 457
VAL A 459
ALA A 468
 None
 0.75A 2j5mA-5hplA:
undetectable		 2j5mA-5hplA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5hpl RSP5
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 686
PHE A 736
GLY A 739
ASN A 779
ASP A 782
 None
 1.41A 2zznB-5hplA:
undetectable		 2zznB-5hplA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 5hpl RSP5
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 763
ASP A 782
ARG A 706
ILE A 762
ILE A 715
 None
 1.38A 4uroA-5hplA:
undetectable		 4uroA-5hplA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 5hpl RSP5
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 763
ASP A 782
ARG A 706
ILE A 762
ILE A 715
 None
 1.37A 4uroB-5hplA:
undetectable		 4uroB-5hplA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5hpl RSP5
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 468
LEU A 507
GLY A 555
LEU A 480
ILE A 457
 None
 1.09A 5m24A-5hplA:
undetectable		 5m24A-5hplA:
22.39