SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hqb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		4 / 5 TYR A 285
SER A 544
THR A 472
ASN A 453
 None
 1.50A 1yvpA-5hqbA:
undetectable		 1yvpA-5hqbA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		4 / 6 ALA A 550
TYR A 539
TYR A 556
ILE A 286
 None
 1.09A 2dcfA-5hqbA:
undetectable		 2dcfA-5hqbA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		5 / 11 GLY A  58
THR A 149
GLU A 147
ILE A  33
PHE A 120
 None
 1.49A 2dr2A-5hqbA:
undetectable		 2dr2A-5hqbA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		5 / 12 PHE A 106
VAL A 104
ILE A  44
ILE A  31
LEU A  57
 None
 1.28A 2ft9A-5hqbA:
2.4		 2ft9A-5hqbA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		5 / 12 PHE A 106
VAL A 104
ILE A  44
PHE A 129
LEU A  57
 None
 1.19A 2ft9A-5hqbA:
2.4		 2ft9A-5hqbA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		4 / 6 ALA A 213
ASP A 430
GLU A 205
ARG A 248
 None
 1.39A 2ouzA-5hqbA:
undetectable		 2ouzA-5hqbA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		4 / 7 ASP A  26
ASN A  28
PHE A  46
SER A 125
 None
 1.40A 2v7uB-5hqbA:
undetectable		 2v7uB-5hqbA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		4 / 7 ALA A 550
TYR A 539
TYR A 556
ILE A 286
 None
 1.11A 2zm7A-5hqbA:
undetectable		 2zm7A-5hqbA:
19.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZQ0_A_ACRA801_1
(ALPHA-GLUCOSIDASE
(ALPHA-GLUCOSIDASE
SUSB))		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		8 / 12 GLU A 173
ASN A 170
GLU A 330
TRP A 336
PHE A 341
HIS A 375
LYS A 405
GLU A 474
 GLC  A 712 ( 2.7A)
GLC  A 712 (-3.2A)
GLC  A 711 (-2.7A)
None
GOL  A 706 (-3.5A)
GLC  A 711 (-4.2A)
GLC  A 711 (-2.8A)
CA  A 701 ( 2.9A)
 0.96A 2zq0A-5hqbA:
48.8		 2zq0A-5hqbA:
39.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZQ0_A_ACRA801_2
(ALPHA-GLUCOSIDASE
(ALPHA-GLUCOSIDASE
SUSB))		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		5 / 9 GLU A 377
VAL A 409
HIS A 455
GLU A 456
PHE A 481
 GLC  A 711 (-3.7A)
GLC  A 712 (-4.7A)
GLC  A 711 (-3.7A)
CA  A 701 ( 3.4A)
None
 1.34A 2zq0A-5hqbA:
48.8		 2zq0A-5hqbA:
39.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZQ0_A_ACRA801_2
(ALPHA-GLUCOSIDASE
(ALPHA-GLUCOSIDASE
SUSB))		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		7 / 9 TRP A 289
TRP A 299
TRP A 340
GLU A 377
VAL A 409
HIS A 455
GLU A 456
 GLC  A 711 (-4.1A)
GLC  A 711 (-4.5A)
GLC  A 711 (-4.8A)
GLC  A 711 (-3.7A)
GLC  A 712 (-4.7A)
GLC  A 711 (-3.7A)
CA  A 701 ( 3.4A)
 0.47A 2zq0A-5hqbA:
48.8		 2zq0A-5hqbA:
39.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZQ0_B_ACRB811_1
(ALPHA-GLUCOSIDASE
(ALPHA-GLUCOSIDASE
SUSB))		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		6 / 12 GLU A 173
ASN A 170
TRP A 336
HIS A 375
GLU A 456
GLU A 474
 GLC  A 712 ( 2.7A)
GLC  A 712 (-3.2A)
None
GLC  A 711 (-4.2A)
CA  A 701 ( 3.4A)
CA  A 701 ( 2.9A)
 1.41A 2zq0B-5hqbA:
57.0		 2zq0B-5hqbA:
39.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZQ0_B_ACRB811_1
(ALPHA-GLUCOSIDASE
(ALPHA-GLUCOSIDASE
SUSB))		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		8 / 12 GLU A 173
ASN A 170
TRP A 336
PHE A 341
HIS A 375
LYS A 405
GLU A 456
GLU A 474
 GLC  A 712 ( 2.7A)
GLC  A 712 (-3.2A)
None
GOL  A 706 (-3.5A)
GLC  A 711 (-4.2A)
GLC  A 711 (-2.8A)
CA  A 701 ( 3.4A)
CA  A 701 ( 2.9A)
 1.01A 2zq0B-5hqbA:
57.0		 2zq0B-5hqbA:
39.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZQ0_B_ACRB811_2
(ALPHA-GLUCOSIDASE
(ALPHA-GLUCOSIDASE
SUSB))		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		7 / 9 TRP A 289
TRP A 299
GLU A 330
TRP A 340
GLU A 377
VAL A 409
HIS A 455
 GLC  A 711 (-4.1A)
GLC  A 711 (-4.5A)
GLC  A 711 (-2.7A)
GLC  A 711 (-4.8A)
GLC  A 711 (-3.7A)
GLC  A 712 (-4.7A)
GLC  A 711 (-3.7A)
 0.49A 2zq0B-5hqbA:
57.0		 2zq0B-5hqbA:
39.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		3 / 3 ARG A 594
ASP A 597
ASP A 572
 None
 0.76A 3jayA-5hqbA:
undetectable		 3jayA-5hqbA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		3 / 3 ARG A 594
ASP A 597
ASP A 572
 None
 0.72A 3jb2A-5hqbA:
undetectable		 3jb2A-5hqbA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		3 / 3 ARG A 594
ASP A 597
ASP A 572
 None
 0.74A 3jb3A-5hqbA:
undetectable		 3jb3A-5hqbA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		5 / 11 ALA A 360
ASP A 357
PHE A 356
ILE A 288
LEU A 372
 None
 1.32A 3qg2B-5hqbA:
undetectable		 3qg2B-5hqbA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		5 / 11 ILE A 358
ALA A 360
PHE A 356
ILE A 288
LEU A 372
 None
 1.31A 3qg2B-5hqbA:
undetectable		 3qg2B-5hqbA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		3 / 3 LYS A  62
GLU A 143
TRP A 231
 None
 1.37A 3v4tH-5hqbA:
undetectable		 3v4tH-5hqbA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		3 / 3 ASP A 355
GLY A 302
TYR A 353
 None
 0.74A 3w9tC-5hqbA:
undetectable		 3w9tC-5hqbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		3 / 3 ASP A 355
GLY A 306
TYR A 353
 None
 0.77A 3w9tC-5hqbA:
undetectable		 3w9tC-5hqbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		3 / 3 ASP A 355
GLY A 302
TYR A 353
 None
 0.75A 3w9tG-5hqbA:
undetectable		 3w9tG-5hqbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		3 / 3 ASP A 355
GLY A 306
TYR A 353
 None
 0.77A 3w9tG-5hqbA:
undetectable		 3w9tG-5hqbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		4 / 5 VAL A 657
LEU A 621
LEU A 624
ILE A 675
 None
 0.89A 4a9jA-5hqbA:
undetectable		 4a9jA-5hqbA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		3 / 3 HIS A 204
GLY A 462
ILE A 265
 None
 0.58A 4k50A-5hqbA:
undetectable		 4k50A-5hqbA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		3 / 3 HIS A 204
GLY A 462
ILE A 265
 None
 0.58A 4k50I-5hqbA:
undetectable		 4k50I-5hqbA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		4 / 6 ASP A 263
GLY A  90
PRO A 468
THR A 466
 None
 1.05A 4l1aB-5hqbA:
undetectable		 4l1aB-5hqbA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		3 / 3 LEU A 606
ARG A 591
MET A 507
 None
 0.93A 4m11C-5hqbA:
undetectable		 4m11C-5hqbA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		3 / 3 ASP A 551
TYR A 556
TRP A 290
 None
 1.41A 4p7nA-5hqbA:
2.5		 4p7nA-5hqbA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		4 / 4 THR A 192
GLY A 253
ASP A 258
SER A 202
 None
 1.40A 4rfqA-5hqbA:
undetectable		 4rfqA-5hqbA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		3 / 3 GLU A 132
ARG A 130
GLN A  79
 None
None
FMT  A 714 (-3.2A)
 0.93A 4rtbA-5hqbA:
6.8		 4rtbA-5hqbA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		4 / 6 GLY A 475
GLU A 173
ASP A 508
ASP A 460
 CL  A 702 ( 3.9A)
GLC  A 712 ( 2.7A)
None
None
 1.05A 4uckB-5hqbA:
undetectable		 4uckB-5hqbA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		3 / 3 ASP A 460
ARG A 591
ARG A  92
 None
 0.88A 4x5iA-5hqbA:
undetectable		 4x5iA-5hqbA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		4 / 7 ARG A 464
ARG A 594
ASP A 572
TYR A 543
 None
 1.09A 5a06A-5hqbA:
undetectable		 5a06A-5hqbA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		4 / 7 ARG A 464
ARG A 594
ASP A 572
TYR A 543
 None
 1.10A 5a06B-5hqbA:
undetectable		 5a06B-5hqbA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		4 / 7 ARG A 464
ARG A 594
ASP A 572
TYR A 543
 None
 1.11A 5a06C-5hqbA:
undetectable		 5a06C-5hqbA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		4 / 7 ARG A 464
ARG A 594
ASP A 572
TYR A 543
 None
 1.09A 5a06D-5hqbA:
2.3		 5a06D-5hqbA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		4 / 7 ARG A 464
ARG A 594
ASP A 572
TYR A 543
 None
 1.08A 5a06E-5hqbA:
2.3		 5a06E-5hqbA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		4 / 7 ARG A 464
ARG A 594
ASP A 572
TYR A 543
 None
 1.12A 5a06F-5hqbA:
undetectable		 5a06F-5hqbA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		4 / 8 ASN A 469
PRO A 468
SER A 278
TRP A 279
 None
 1.33A 5amiB-5hqbA:
undetectable		 5amiB-5hqbA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		3 / 3 ASP A 460
ARG A 591
ARG A  92
 None
 0.85A 5eajB-5hqbA:
undetectable		 5eajB-5hqbA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		5 / 12 TYR A 176
ILE A  44
VAL A 215
GLY A 126
LEU A 259
 None
 1.32A 5esgA-5hqbA:
undetectable		 5esgA-5hqbA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		5 / 12 GLY A 374
LEU A 328
ILE A 458
TYR A 385
TYR A 438
 None
 1.35A 5fepA-5hqbA:
3.7		 5fepA-5hqbA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		5 / 12 GLY A 374
LEU A 328
ILE A 458
TYR A 385
TYR A 438
 None
 1.33A 5fesA-5hqbA:
3.4		 5fesA-5hqbA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		5 / 9 THR A 510
LEU A 538
PRO A 528
LEU A 542
MET A 507
 None
 1.25A 5g48B-5hqbA:
undetectable		 5g48B-5hqbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		4 / 5 GLY A 671
PRO A 490
THR A 530
THR A 610
 None
 1.12A 5h5fA-5hqbA:
undetectable		 5h5fA-5hqbA:
15.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HQA_A_ACRA705_1
(ALPHA-GLUCOSIDASE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		11 / 12 ARG A 171
GLU A 173
HIS A 293
GLU A 330
TRP A 336
HIS A 375
LYS A 405
VAL A 409
GLU A 456
GLU A 474
TRP A 484
 GLC  A 712 ( 2.6A)
GLC  A 712 ( 2.7A)
GLC  A 711 ( 4.0A)
GLC  A 711 (-2.7A)
None
GLC  A 711 (-4.2A)
GLC  A 711 (-2.8A)
GLC  A 712 (-4.7A)
CA  A 701 ( 3.4A)
CA  A 701 ( 2.9A)
GLC  A 713 ( 3.5A)
 0.12A 5hqaA-5hqbA:
74.2		 5hqaA-5hqbA:
99.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		8 / 8 ASN A 170
TRP A 289
TRP A 299
TRP A 340
PHE A 341
GLU A 377
HIS A 455
THR A 486
 GLC  A 712 (-3.2A)
GLC  A 711 (-4.1A)
GLC  A 711 (-4.5A)
GLC  A 711 (-4.8A)
GOL  A 706 (-3.5A)
GLC  A 711 (-3.7A)
GLC  A 711 (-3.7A)
None
 0.17A 5hqaA-5hqbA:
74.2		 5hqaA-5hqbA:
99.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5hqb ALPHA-GLUCOSIDASE
(Pseudoalteromona
s
sp.
K8) 		4 / 7 ASP A 355
PHE A 356
GLY A 331
GLY A 306
 None
 0.68A 5n9xA-5hqbA:
undetectable		 5n9xA-5hqbA:
21.87