SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hqj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Paraburkholderia
graminis) 		4 / 5 LYS A 229
ALA A 228
ASP A 253
GLY A 224
 None
 1.11A 1e7cA-5hqjA:
undetectable		 1e7cA-5hqjA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Paraburkholderia
graminis) 		4 / 7 GLY A 131
THR A 298
GLN A 269
PHE A  44
 None
None
64K  A 401 (-2.8A)
64K  A 401 ( 4.2A)
 1.07A 2qx4A-5hqjA:
2.5
2qx4B-5hqjA:
4.7		 2qx4A-5hqjA:
20.75
2qx4B-5hqjA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Paraburkholderia
graminis) 		4 / 7 GLY A 131
THR A 298
PHE A  43
PHE A  44
 None
None
64K  A 401 ( 2.8A)
64K  A 401 ( 4.2A)
 1.18A 2qx4A-5hqjA:
2.5
2qx4B-5hqjA:
4.7		 2qx4A-5hqjA:
20.75
2qx4B-5hqjA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Paraburkholderia
graminis) 		3 / 3 LYS A  38
ILE A 158
PHE A 217
 64K  A 401 (-2.5A)
None
None
 0.94A 3j7zS-5hqjA:
undetectable
3j7za-5hqjA:
undetectable		 3j7zS-5hqjA:
18.12
3j7za-5hqjA:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Paraburkholderia
graminis) 		5 / 10 THR A 144
GLY A 146
PHE A 217
GLU A 143
LEU A 149
 None
 1.26A 3kvrA-5hqjA:
2.7		 3kvrA-5hqjA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Paraburkholderia
graminis) 		5 / 10 THR A 144
GLY A 146
PHE A 217
GLU A 143
LEU A 149
 None
 1.28A 3kvrB-5hqjA:
3.9		 3kvrB-5hqjA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Paraburkholderia
graminis) 		5 / 9 THR A 206
LEU A 213
GLY A 215
VAL A 227
VAL A 203
 None
 1.41A 4c9kB-5hqjA:
undetectable		 4c9kB-5hqjA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Paraburkholderia
graminis) 		5 / 12 ALA A 172
GLY A 173
GLY A 138
ASN A 134
ASN A 168
 None
 1.07A 4obwB-5hqjA:
undetectable		 4obwB-5hqjA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Paraburkholderia
graminis) 		4 / 8 PRO A  67
PHE A  44
TRP A  64
TYR A  62
 None
64K  A 401 ( 4.2A)
None
None
 1.04A 4v2zC-5hqjA:
undetectable		 4v2zC-5hqjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Paraburkholderia
graminis) 		5 / 12 LEU A 251
ASN A  95
ASP A 118
ASN A 166
PHE A 248
 None
None
64K  A 401 (-2.7A)
64K  A 401 (-2.6A)
64K  A 401 ( 4.9A)
 1.36A 5dv4A-5hqjA:
undetectable		 5dv4A-5hqjA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Paraburkholderia
graminis) 		5 / 12 VAL A 222
PRO A 225
ALA A 226
THR A 189
ILE A 216
 CL  A 402 ( 4.4A)
CL  A 402 ( 4.9A)
None
None
None
 1.41A 5hgcA-5hqjA:
undetectable		 5hgcA-5hqjA:
19.49