SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hqn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 12 HIS A 206
HIS A 457
HIS A 280
HIS A 317
ASP A 276
 ZN  A 701 ( 3.3A)
ZN  A 701 ( 3.1A)
PO4  A 710 (-4.2A)
PO4  A 710 (-3.7A)
ZN  A 702 (-2.3A)
 1.32A 1a4lA-5hqnA:
undetectable		 1a4lA-5hqnA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 12 HIS A 206
HIS A 457
HIS A 280
HIS A 317
ASP A 276
 ZN  A 701 ( 3.3A)
ZN  A 701 ( 3.1A)
PO4  A 710 (-4.2A)
PO4  A 710 (-3.7A)
ZN  A 702 (-2.3A)
 1.31A 1a4lC-5hqnA:
undetectable		 1a4lC-5hqnA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 12 ALA A 522
GLY A 243
TRP A 242
LEU A 205
LEU A 259
 None
 0.80A 1eizA-5hqnA:
undetectable		 1eizA-5hqnA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 12 ALA A 522
GLY A 243
TRP A 242
LEU A 205
LEU A 259
 None
 0.81A 1ej0A-5hqnA:
undetectable		 1ej0A-5hqnA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		3 / 3 ASP A 276
HIS A 317
HIS A 206
 ZN  A 702 (-2.3A)
PO4  A 710 (-3.7A)
ZN  A 701 ( 3.3A)
 0.62A 1oe1A-5hqnA:
undetectable		 1oe1A-5hqnA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		3 / 3 ASP A 276
HIS A 317
HIS A 206
 ZN  A 702 (-2.3A)
PO4  A 710 (-3.7A)
ZN  A 701 ( 3.3A)
 0.61A 1oe3A-5hqnA:
undetectable		 1oe3A-5hqnA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		3 / 3 ARG A 494
VAL A 476
TRP A 551
 None
 1.21A 1qw6A-5hqnA:
undetectable		 1qw6A-5hqnA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		3 / 3 ARG A 494
VAL A 476
TRP A 551
 None
 1.26A 1qwcA-5hqnA:
undetectable		 1qwcA-5hqnA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		3 / 3 ARG A 494
VAL A 476
TRP A 551
 None
 1.23A 1vagA-5hqnA:
undetectable		 1vagA-5hqnA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		3 / 3 ARG A 494
VAL A 476
TRP A 551
 None
 1.24A 1zviA-5hqnA:
undetectable		 1zviA-5hqnA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 7 SER A 471
ARG A 472
LEU A 474
GLU A 445
 None
 1.01A 2cdqB-5hqnA:
undetectable		 2cdqB-5hqnA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 7 LEU A 479
PRO A 425
GLY A 315
ASP A 276
 None
None
None
ZN  A 702 (-2.3A)
 0.97A 2ddwB-5hqnA:
undetectable		 2ddwB-5hqnA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 4 LEU A 470
THR A 469
ILE A 463
HIS A 552
 None
 1.03A 2jfaB-5hqnA:
undetectable		 2jfaB-5hqnA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		3 / 3 ASP A 276
HIS A 317
HIS A 206
 ZN  A 702 (-2.3A)
PO4  A 710 (-3.7A)
ZN  A 701 ( 3.3A)
 0.63A 2xxgA-5hqnA:
undetectable		 2xxgA-5hqnA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		3 / 3 ASP A 276
HIS A 317
HIS A 206
 ZN  A 702 (-2.3A)
PO4  A 710 (-3.7A)
ZN  A 701 ( 3.3A)
 0.63A 2xxgC-5hqnA:
undetectable		 2xxgC-5hqnA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 5 HIS A 206
HIS A 280
ASP A 276
HIS A 317
 ZN  A 701 ( 3.3A)
PO4  A 710 (-4.2A)
ZN  A 702 (-2.3A)
PO4  A 710 (-3.7A)
 1.26A 3c0zA-5hqnA:
undetectable		 3c0zA-5hqnA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 6 GLY A 240
GLU A 244
GLY A 238
ASN A 523
 None
 0.98A 3e9rA-5hqnA:
undetectable		 3e9rA-5hqnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 6 GLY A 240
GLU A 244
GLY A 238
ASN A 523
 None
 0.98A 3e9rC-5hqnA:
undetectable		 3e9rC-5hqnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 7 LEU A 408
PRO A 426
GLY A 422
MET A 380
 None
 0.94A 3hcnA-5hqnA:
undetectable		 3hcnA-5hqnA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 5 GLY A 238
GLU A 244
GLY A 214
PRO A 217
 None
 1.04A 3onnA-5hqnA:
undetectable		 3onnA-5hqnA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 7 ASN A 323
ASP A 204
HIS A 457
HIS A 206
 None
ZN  A 701 (-3.0A)
ZN  A 701 ( 3.1A)
ZN  A 701 ( 3.3A)
 1.01A 3t01A-5hqnA:
undetectable		 3t01A-5hqnA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 12 SER A 197
PHE A 452
VAL A 199
ALA A 449
HIS A 507
 None
 1.34A 3u9fD-5hqnA:
undetectable
3u9fE-5hqnA:
undetectable		 3u9fD-5hqnA:
17.07
3u9fE-5hqnA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		3 / 3 GLN A 451
PHE A 464
TYR A 437
 None
 0.88A 3ucjB-5hqnA:
undetectable		 3ucjB-5hqnA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		3 / 3 GLN A 451
PHE A 464
TYR A 437
 None
 0.86A 3ucjA-5hqnA:
undetectable		 3ucjA-5hqnA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 12 TRP A 283
GLU A 210
HIS A 209
ASP A 289
ASP A 281
 None
 1.47A 3ximB-5hqnA:
3.6		 3ximB-5hqnA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 12 TRP A 283
GLU A 210
HIS A 209
ASP A 289
ASP A 281
 None
 1.45A 3ximD-5hqnA:
3.1		 3ximD-5hqnA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 12 PHE A 478
PHE A 453
PRO A 426
TYR A 438
ALA A 475
 None
 1.21A 4a83A-5hqnA:
undetectable		 4a83A-5hqnA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 12 PHE A 478
PHE A 453
PRO A 426
TYR A 438
ALA A 475
 None
 1.23A 4a84A-5hqnA:
undetectable		 4a84A-5hqnA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		3 / 3 HIS A 317
GLU A 318
ASN A 381
 PO4  A 710 (-3.7A)
None
None
 0.97A 4bupB-5hqnA:
undetectable		 4bupB-5hqnA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		3 / 3 PHE A 268
VAL A 495
GLU A 513
 None
 0.79A 4fvqA-5hqnA:
undetectable		 4fvqA-5hqnA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		3 / 3 GLU A 460
ILE A 424
ALA A 477
 None
 0.63A 4wnwB-5hqnA:
undetectable		 4wnwB-5hqnA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 5 ALA A 342
HIS A 455
PRO A 278
PHE A 325
 None
ZN  A 702 ( 3.1A)
None
None
 1.34A 4ze2A-5hqnA:
undetectable		 4ze2A-5hqnA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 12 SER A 505
VAL A 199
MET A 547
PHE A 452
HIS A 507
 None
 1.47A 4zj8A-5hqnA:
undetectable		 4zj8A-5hqnA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 12 HIS A 206
ASP A 276
LEU A 339
PHE A 325
HIS A 423
 ZN  A 701 ( 3.3A)
ZN  A 702 (-2.3A)
None
None
ZN  A 702 (-3.2A)
 1.39A 5dv4A-5hqnA:
4.3		 5dv4A-5hqnA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 12 ILE A 440
ALA A 477
LEU A 479
GLY A 454
THR A 274
 None
 0.97A 5igtA-5hqnA:
undetectable		 5igtA-5hqnA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 4 HIS A 457
HIS A 317
HIS A 280
HIS A 206
 ZN  A 701 ( 3.1A)
PO4  A 710 (-3.7A)
PO4  A 710 (-4.2A)
ZN  A 701 ( 3.3A)
 0.89A 5mhwA-5hqnA:
undetectable		 5mhwA-5hqnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 4 HIS A 457
HIS A 317
HIS A 280
HIS A 206
 ZN  A 701 ( 3.1A)
PO4  A 710 (-3.7A)
PO4  A 710 (-4.2A)
ZN  A 701 ( 3.3A)
 0.89A 5mhxA-5hqnA:
undetectable		 5mhxA-5hqnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 4 HIS A 457
HIS A 317
HIS A 280
HIS A 206
 ZN  A 701 ( 3.1A)
PO4  A 710 (-3.7A)
PO4  A 710 (-4.2A)
ZN  A 701 ( 3.3A)
 0.89A 5mhyA-5hqnA:
undetectable		 5mhyA-5hqnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 4 HIS A 457
HIS A 317
HIS A 280
HIS A 206
 ZN  A 701 ( 3.1A)
PO4  A 710 (-3.7A)
PO4  A 710 (-4.2A)
ZN  A 701 ( 3.3A)
 0.89A 5mhzA-5hqnA:
undetectable		 5mhzA-5hqnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 4 HIS A 457
HIS A 317
HIS A 280
HIS A 206
 ZN  A 701 ( 3.1A)
PO4  A 710 (-3.7A)
PO4  A 710 (-4.2A)
ZN  A 701 ( 3.3A)
 0.89A 5mi1A-5hqnA:
undetectable		 5mi1A-5hqnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 4 HIS A 457
HIS A 317
HIS A 280
HIS A 206
 ZN  A 701 ( 3.1A)
PO4  A 710 (-3.7A)
PO4  A 710 (-4.2A)
ZN  A 701 ( 3.3A)
 0.89A 5mi2A-5hqnA:
undetectable		 5mi2A-5hqnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 4 HIS A 457
HIS A 317
HIS A 280
HIS A 206
 ZN  A 701 ( 3.1A)
PO4  A 710 (-3.7A)
PO4  A 710 (-4.2A)
ZN  A 701 ( 3.3A)
 0.90A 5miaA-5hqnA:
undetectable		 5miaA-5hqnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 4 HIS A 457
HIS A 317
HIS A 280
HIS A 206
 ZN  A 701 ( 3.1A)
PO4  A 710 (-3.7A)
PO4  A 710 (-4.2A)
ZN  A 701 ( 3.3A)
 0.90A 5mibA-5hqnA:
undetectable		 5mibA-5hqnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 4 HIS A 457
HIS A 317
HIS A 280
HIS A 206
 ZN  A 701 ( 3.1A)
PO4  A 710 (-3.7A)
PO4  A 710 (-4.2A)
ZN  A 701 ( 3.3A)
 0.90A 5micA-5hqnA:
undetectable		 5micA-5hqnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 4 HIS A 457
HIS A 317
HIS A 280
HIS A 206
 ZN  A 701 ( 3.1A)
PO4  A 710 (-3.7A)
PO4  A 710 (-4.2A)
ZN  A 701 ( 3.3A)
 0.89A 5midA-5hqnA:
undetectable		 5midA-5hqnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 4 HIS A 457
HIS A 317
HIS A 280
HIS A 206
 ZN  A 701 ( 3.1A)
PO4  A 710 (-3.7A)
PO4  A 710 (-4.2A)
ZN  A 701 ( 3.3A)
 0.90A 5mieA-5hqnA:
undetectable		 5mieA-5hqnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 12 LEU A 373
LEU A 367
THR A 274
ILE A 376
ALA A 366
 None
 1.30A 5nm5B-5hqnA:
undetectable		 5nm5B-5hqnA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 12 LEU A 517
GLY A 492
GLU A 256
LEU A 259
LEU A 262
 None
 1.21A 5nwvA-5hqnA:
undetectable		 5nwvA-5hqnA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QJQ_A_K1SA304_0
(ADP-SUGAR
PYROPHOSPHATASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 5 GLU A 406
TRP A 403
VAL A 405
LEU A 378
 None
 1.32A 5qjqA-5hqnA:
0.0
5qjqB-5hqnA:
0.0		 5qjqA-5hqnA:
19.28
5qjqB-5hqnA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QJQ_B_K1SB304_0
(ADP-SUGAR
PYROPHOSPHATASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 5 TRP A 403
VAL A 405
LEU A 378
GLU A 406
 None
 1.31A 5qjqA-5hqnA:
undetectable
5qjqB-5hqnA:
undetectable		 5qjqA-5hqnA:
19.28
5qjqB-5hqnA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 6 ARG A 227
THR A 215
ASP A 216
ASP A 221
 None
 1.19A 5tdzA-5hqnA:
undetectable		 5tdzA-5hqnA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 4 LEU A 351
LEU A 367
SER A 377
ALA A 366
 None
 0.97A 5uunA-5hqnA:
undetectable		 5uunA-5hqnA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		4 / 8 SER A 257
THR A 254
PRO A 491
ILE A 516
 None
 1.15A 5vkqB-5hqnA:
undetectable
5vkqC-5hqnA:
undetectable		 5vkqB-5hqnA:
14.15
5vkqC-5hqnA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		3 / 3 HIS A 317
GLU A 318
ASN A 381
 PO4  A 710 (-3.7A)
None
None
 0.91A 5wbvA-5hqnA:
undetectable		 5wbvA-5hqnA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		3 / 3 HIS A 317
GLU A 318
ASN A 381
 PO4  A 710 (-3.7A)
None
None
 0.90A 5wbvB-5hqnA:
undetectable		 5wbvB-5hqnA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 10 PRO A 312
SER A 377
LEU A 294
ILE A 277
GLY A 275
 None
 1.48A 6dlzA-5hqnA:
undetectable
6dlzD-5hqnA:
undetectable		 6dlzA-5hqnA:
10.11
6dlzD-5hqnA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 10 ILE A 277
GLY A 275
PRO A 312
SER A 377
LEU A 294
 None
 1.48A 6dlzB-5hqnA:
undetectable
6dlzC-5hqnA:
undetectable		 6dlzB-5hqnA:
10.11
6dlzC-5hqnA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 10 PRO A 312
SER A 377
LEU A 294
ILE A 277
GLY A 275
 None
 1.49A 6dm1A-5hqnA:
undetectable
6dm1D-5hqnA:
undetectable		 6dm1A-5hqnA:
10.11
6dm1D-5hqnA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 10 ILE A 277
GLY A 275
PRO A 312
SER A 377
LEU A 294
 None
 1.49A 6dm1B-5hqnA:
undetectable
6dm1C-5hqnA:
undetectable		 6dm1B-5hqnA:
10.11
6dm1C-5hqnA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 12 VAL A 314
ASN A 381
ARG A 287
PRO A 326
GLY A 324
 None
None
NAG  A 703 (-3.4A)
None
None
 1.22A 6gnfA-5hqnA:
undetectable		 6gnfA-5hqnA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 12 VAL A 314
ASN A 381
ARG A 287
PRO A 326
GLY A 324
 None
None
NAG  A 703 (-3.4A)
None
None
 1.23A 6gnfC-5hqnA:
undetectable		 6gnfC-5hqnA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 5hqn SPHINGOMYELIN
PHOSPHODIESTERASE
(Mus
musculus) 		5 / 9 ILE A 424
GLY A 315
GLY A 362
TYR A 340
ASN A 381
 None
 1.34A 6nm4B-5hqnA:
undetectable		 6nm4B-5hqnA:
15.19