SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 5hqw PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		5 / 12 GLY A2428
LEU A2350
VAL A2461
LEU A2460
ALA A2459
 None
 0.94A 1jipA-5hqwA:
undetectable		 1jipA-5hqwA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 5hqw PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		4 / 6 ALA A2425
LEU A2423
ILE A2478
CYH A2481
 None
 0.99A 1sbrA-5hqwA:
undetectable
1sbrB-5hqwA:
undetectable		 1sbrA-5hqwA:
20.47
1sbrB-5hqwA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5hqw PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		4 / 5 LEU A2348
ASP A2479
ALA A2347
ILE A2487
 None
 1.01A 2aofB-5hqwA:
undetectable		 2aofB-5hqwA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5hqw PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		4 / 7 MET A2419
ILE A2449
PRO A2441
TRP A2289
 None
 1.10A 2pnjB-5hqwA:
undetectable		 2pnjB-5hqwA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5hqw PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		5 / 12 ALA A2259
LEU A2414
TYR A2378
HIS A2382
ALA A2425
 None
 1.02A 3tm4B-5hqwA:
undetectable		 3tm4B-5hqwA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 5hqw PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		4 / 6 HIS A2332
TYR A2319
ALA A2290
GLU A2317
 None
 1.01A 4ae1A-5hqwA:
undetectable		 4ae1A-5hqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5hqw PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		4 / 8 MET A2419
ILE A2449
PRO A2441
TRP A2289
 None
 1.15A 4f4dB-5hqwA:
undetectable		 4f4dB-5hqwA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5hqw PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		5 / 12 GLY A2428
SER A2464
PHE A2494
THR A2495
VAL A2258
 None
 1.27A 5d0yA-5hqwA:
undetectable		 5d0yA-5hqwA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5hqw PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		4 / 7 GLU A2445
GLY A2466
SER A2464
ALA A2468
 None
 0.97A 5e26A-5hqwA:
undetectable
5e26B-5hqwA:
undetectable		 5e26A-5hqwA:
21.27
5e26B-5hqwA:
21.27