SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hr4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		3 / 3 ALA C 422
VAL C 424
TRP C 427
 None
 0.82A 1av2C-5hr4C:
undetectable
1av2D-5hr4C:
undetectable		 1av2C-5hr4C:
2.72
1av2D-5hr4C:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		4 / 7 ARG C 447
ASP C 407
TYR C 374
ARG C 378
 None
 1.08A 1ceaB-5hr4C:
undetectable		 1ceaB-5hr4C:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		4 / 8 LEU C 282
LEU C 193
TYR C 189
LEU C 225
 None
 1.13A 1hk2A-5hr4C:
undetectable		 1hk2A-5hr4C:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		3 / 3 ALA C 422
VAL C 424
TRP C 427
 None
 0.87A 1nt5A-5hr4C:
undetectable		 1nt5A-5hr4C:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		3 / 3 ALA C 422
VAL C 424
TRP C 427
 None
 0.87A 1nt5B-5hr4C:
undetectable		 1nt5B-5hr4C:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		3 / 3 ALA C 422
VAL C 424
TRP C 427
 None
 0.66A 1nt6A-5hr4C:
undetectable		 1nt6A-5hr4C:
2.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		3 / 3 ALA C 422
VAL C 424
TRP C 427
 None
 0.66A 1nt6B-5hr4C:
undetectable		 1nt6B-5hr4C:
2.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		3 / 3 ALA C 422
VAL C 424
TRP C 427
 None
 0.86A 1w5uC-5hr4C:
undetectable
1w5uD-5hr4C:
undetectable		 1w5uC-5hr4C:
2.72
1w5uD-5hr4C:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 ILE C 321
ASN C 368
LEU C 426
GLU C 376
ARG C 375
 None
SFG  C1002 (-4.1A)
None
None
None
 1.29A 2bxfB-5hr4C:
undetectable		 2bxfB-5hr4C:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 9 ILE C 762
PHE C 682
LEU C 852
ARG C 757
ILE C 683
 None
 1.24A 2f78A-5hr4C:
1.4		 2f78A-5hr4C:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		3 / 3 TRP C 427
ALA C 422
VAL C 424
 None
 0.80A 2izqA-5hr4C:
undetectable
2izqB-5hr4C:
undetectable		 2izqA-5hr4C:
2.72
2izqB-5hr4C:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 ILE C 321
ALA C 363
GLY C 365
ASN C 481
PRO C 483
 None
SFG  C1002 (-3.9A)
SFG  C1002 (-3.4A)
SFG  C1002 (-3.8A)
SFG  C1002 (-4.1A)
 0.32A 2okcA-5hr4C:
18.2		 2okcA-5hr4C:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 ILE C 321
ALA C 363
GLY C 365
ASN C 481
PRO C 483
 None
SFG  C1002 (-3.9A)
SFG  C1002 (-3.4A)
SFG  C1002 (-3.8A)
SFG  C1002 (-4.1A)
 0.34A 2okcB-5hr4C:
18.4		 2okcB-5hr4C:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 PHE C 882
ALA C 627
THR C 819
MET C 793
ARG C 891
 None
 1.28A 2v0mC-5hr4C:
undetectable		 2v0mC-5hr4C:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		6 / 12 GLY C 365
GLU C 413
ILE C 414
ASN C 460
ALA C 461
THR C 316
 SFG  C1002 (-3.4A)
SFG  C1002 (-2.8A)
SFG  C1002 (-3.9A)
SFG  C1002 (-3.2A)
SFG  C1002 (-3.8A)
SFG  C1002 (-4.0A)
 0.87A 2vdvE-5hr4C:
7.1		 2vdvE-5hr4C:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		6 / 11 GLY C 365
GLU C 413
ILE C 414
ASN C 460
ALA C 461
THR C 316
 SFG  C1002 (-3.4A)
SFG  C1002 (-2.8A)
SFG  C1002 (-3.9A)
SFG  C1002 (-3.2A)
SFG  C1002 (-3.8A)
SFG  C1002 (-4.0A)
 0.87A 2vdvF-5hr4C:
7.1		 2vdvF-5hr4C:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 11 LEU C 266
ALA C 269
PHE C 271
GLN C 420
PHE C 233
 None
 1.32A 3bszF-5hr4C:
undetectable		 3bszF-5hr4C:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		6 / 12 GLY C 365
GLU C 413
ILE C 414
ASN C 460
ALA C 461
THR C 316
 SFG  C1002 (-3.4A)
SFG  C1002 (-2.8A)
SFG  C1002 (-3.9A)
SFG  C1002 (-3.2A)
SFG  C1002 (-3.8A)
SFG  C1002 (-4.0A)
 0.92A 3ckkA-5hr4C:
7.2		 3ckkA-5hr4C:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		4 / 5 ILE C 833
THR C 792
PHE C 882
TYR C 880
 None
 1.13A 3em0A-5hr4C:
undetectable		 3em0A-5hr4C:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 11 GLU C 413
ILE C 414
ALA C 461
ASN C 481
PRO C 483
 SFG  C1002 (-2.8A)
SFG  C1002 (-3.9A)
SFG  C1002 (-3.8A)
SFG  C1002 (-3.8A)
SFG  C1002 (-4.1A)
 0.69A 3grvA-5hr4C:
13.1		 3grvA-5hr4C:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 GLU C 413
ILE C 414
ALA C 461
ASN C 481
PRO C 483
 SFG  C1002 (-2.8A)
SFG  C1002 (-3.9A)
SFG  C1002 (-3.8A)
SFG  C1002 (-3.8A)
SFG  C1002 (-4.1A)
 0.71A 3gryA-5hr4C:
13.0		 3gryA-5hr4C:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		4 / 8 HIS C 431
ASN C 434
MET C 435
ILE C 437
 None
 1.33A 3kp6A-5hr4C:
undetectable
3kp6B-5hr4C:
undetectable		 3kp6A-5hr4C:
11.22
3kp6B-5hr4C:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		3 / 3 ALA C 422
VAL C 424
TRP C 427
 None
 0.81A 3l8lA-5hr4C:
undetectable
3l8lB-5hr4C:
undetectable		 3l8lA-5hr4C:
2.72
3l8lB-5hr4C:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OSH_A_OINA5811_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 9 LEU C 298
PHE C 295
ILE C 290
TRP C 287
PHE C 198
 None
 1.17A 3oshA-5hr4C:
undetectable		 3oshA-5hr4C:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		3 / 3 THR C 316
ASP C 361
GLU C 413
 SFG  C1002 (-4.0A)
SFG  C1002 ( 4.9A)
SFG  C1002 (-2.8A)
 0.72A 3qowA-5hr4C:
9.3		 3qowA-5hr4C:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5hr4 MMEI
(Methylophilus
methylotrophus) 		3 / 3 ASP C 873
LYS C 874
ASP C 877
 None
 0.63A 4a7tA-5hr4C:
undetectable		 4a7tA-5hr4C:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		3 / 3 GLU C 751
TYR C 776
SER C 812
 None
 0.93A 4at0A-5hr4C:
undetectable		 4at0A-5hr4C:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		4 / 6 ARG C 168
ASP C 201
GLU C 212
LEU C 282
 None
CA  C1001 (-2.1A)
None
None
 1.37A 4ax8A-5hr4C:
9.4		 4ax8A-5hr4C:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		4 / 8 PHE C 198
ALA C 199
LEU C 450
LEU C 261
 None
 0.94A 4ejgB-5hr4C:
1.3		 4ejgB-5hr4C:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 LEU C 194
LEU C 190
LEU C 172
ILE C 290
ILE C 161
 None
 1.22A 4j24B-5hr4C:
undetectable		 4j24B-5hr4C:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		3 / 3 ILE C 421
MET C 303
ARG C 308
 None
 0.94A 4lnwA-5hr4C:
undetectable		 4lnwA-5hr4C:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		3 / 3 ILE C 421
MET C 303
ARG C 308
 None
 0.93A 4lnxA-5hr4C:
undetectable		 4lnxA-5hr4C:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 LEU C 865
GLY C 854
ASN C 849
ALA C 853
ASN C 684
 None
 1.42A 4pclB-5hr4C:
11.4		 4pclB-5hr4C:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		4 / 7 ASN C 481
PRO C 482
PHE C 535
PHE C 563
 SFG  C1002 (-3.8A)
None
None
None
 1.49A 4v32C-5hr4C:
undetectable		 4v32C-5hr4C:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		3 / 3 THR C 316
ASP C 361
GLU C 413
 SFG  C1002 (-4.0A)
SFG  C1002 ( 4.9A)
SFG  C1002 (-2.8A)
 0.54A 5fa8A-5hr4C:
11.0		 5fa8A-5hr4C:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 ALA C 461
PRO C 483
GLY C 365
GLU C 413
GLU C 415
 SFG  C1002 (-3.8A)
SFG  C1002 (-4.1A)
SFG  C1002 (-3.4A)
SFG  C1002 (-2.8A)
None
 0.53A 5hfjA-5hr4C:
undetectable		 5hfjA-5hr4C:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 ALA C 461
PRO C 483
GLY C 365
GLU C 413
GLU C 415
 SFG  C1002 (-3.8A)
SFG  C1002 (-4.1A)
SFG  C1002 (-3.4A)
SFG  C1002 (-2.8A)
None
 0.62A 5hfjD-5hr4C:
2.6		 5hfjD-5hr4C:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 11 LEU C 498
GLY C 493
LEU C 511
VAL C 485
ALA C 516
 None
 1.09A 5o96A-5hr4C:
undetectable
5o96B-5hr4C:
undetectable		 5o96A-5hr4C:
15.12
5o96B-5hr4C:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		4 / 6 TYR C 899
TRP C 797
HIS C 794
TYR C 618
 None
 1.24A 5ov9A-5hr4C:
2.1		 5ov9A-5hr4C:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		4 / 7 TYR C 899
TRP C 797
HIS C 794
TYR C 618
 None
 1.23A 5ov9B-5hr4C:
undetectable		 5ov9B-5hr4C:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 ILE C 214
ASP C 221
LEU C 219
GLY C 222
ASP C 248
 None
 1.14A 5x66A-5hr4C:
undetectable
5x66B-5hr4C:
undetectable		 5x66A-5hr4C:
14.36
5x66B-5hr4C:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 9 ILE C 290
LEU C 298
GLY C 296
PHE C 295
ASN C 368
 None
None
None
None
SFG  C1002 (-4.1A)
 1.39A 5x66C-5hr4C:
undetectable		 5x66C-5hr4C:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 ALA C 363
GLY C 365
PRO C 418
LEU C 462
ASN C 481
 SFG  C1002 (-3.9A)
SFG  C1002 (-3.4A)
None
SFG  C1002 ( 4.4A)
SFG  C1002 (-3.8A)
 0.57A 5ybbA-5hr4C:
16.9		 5ybbA-5hr4C:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		4 / 5 THR C 316
ASP C 361
GLU C 413
ASN C 460
 SFG  C1002 (-4.0A)
SFG  C1002 ( 4.9A)
SFG  C1002 (-2.8A)
SFG  C1002 (-3.2A)
 0.53A 5ybbA-5hr4C:
16.9		 5ybbA-5hr4C:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 THR C 316
ASP C 361
CYH C 366
LEU C 462
ASN C 481
 SFG  C1002 (-4.0A)
SFG  C1002 ( 4.9A)
SFG  C1002 (-3.2A)
SFG  C1002 ( 4.4A)
SFG  C1002 (-3.8A)
 1.04A 5ybbB-5hr4C:
17.1		 5ybbB-5hr4C:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		6 / 12 THR C 316
ASP C 361
PRO C 418
LEU C 462
ASN C 481
PRO C 483
 SFG  C1002 (-4.0A)
SFG  C1002 ( 4.9A)
None
SFG  C1002 ( 4.4A)
SFG  C1002 (-3.8A)
SFG  C1002 (-4.1A)
 0.62A 5ybbB-5hr4C:
17.1		 5ybbB-5hr4C:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 7 ALA C 363
GLY C 365
GLY C 367
GLU C 413
ASN C 460
 SFG  C1002 (-3.9A)
SFG  C1002 (-3.4A)
None
SFG  C1002 (-2.8A)
SFG  C1002 (-3.2A)
 0.74A 5ybbB-5hr4C:
16.9		 5ybbB-5hr4C:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		6 / 12 LEU C 428
ILE C 290
LEU C 298
GLY C 296
PHE C 295
ASN C 368
 None
None
None
None
None
SFG  C1002 (-4.1A)
 1.19A 6qxsB-5hr4C:
undetectable		 6qxsB-5hr4C:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 LEU C 428
ILE C 290
LEU C 298
GLY C 296
ASN C 368
 None
None
None
None
SFG  C1002 (-4.1A)
 1.00A 6qxsD-5hr4C:
undetectable		 6qxsD-5hr4C:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 11 ILE C 290
LEU C 298
GLY C 296
PHE C 295
ASN C 368
 None
None
None
None
SFG  C1002 (-4.1A)
 1.33A 6r2eG-5hr4C:
undetectable		 6r2eG-5hr4C:
15.67