SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hr6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		5 / 10 GLU A 147
VAL A  99
GLY A 100
ASN A 140
VAL A 123
 None
 1.28A 1v3qE-5hr6A:
undetectable		 1v3qE-5hr6A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		4 / 8 CYH A 132
GLU A 180
SER A 233
VAL A 280
 SF4  A 502 ( 2.2A)
MET  A 501 (-4.0A)
MET  A 501 ( 2.6A)
5AD  A 503 (-4.8A)
 0.69A 2fb2A-5hr6A:
12.2		 2fb2A-5hr6A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		5 / 12 VAL A 333
ILE A 277
ILE A 306
CYH A 304
PHE A 339
 None
 1.15A 2ft9A-5hr6A:
undetectable		 2ft9A-5hr6A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		5 / 11 GLY A 348
SER A  89
ASP A 112
THR A  92
GLY A  91
 None
 1.44A 2hmaA-5hr6A:
undetectable		 2hmaA-5hr6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		3 / 3 GLU A 193
LEU A 196
ASP A 197
 None
MG  A 504 (-4.9A)
None
 0.40A 3ko0T-5hr6A:
undetectable		 3ko0T-5hr6A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		5 / 11 ASP A  34
VAL A  74
ALA A  75
ILE A  18
ARG A  25
 None
 1.11A 3n23A-5hr6A:
undetectable		 3n23A-5hr6A:
17.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RFA_A_SAMA406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		10 / 12 PHE A 131
CYH A 132
MET A 176
GLU A 180
PRO A 181
HIS A 235
VAL A 280
ILE A 309
TRP A 311
ASN A 312
 5AD  A 503 (-4.6A)
SF4  A 502 ( 2.2A)
A  C  37 ( 3.7A)
MET  A 501 (-4.0A)
MET  A 501 ( 4.9A)
5AD  A 503 (-3.7A)
5AD  A 503 (-4.8A)
5AD  A 503 (-4.1A)
5AD  A 503 (-4.0A)
SMC  A 355 (-3.7A)
 0.64A 3rfaA-5hr6A:
50.5		 3rfaA-5hr6A:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RFA_A_SAMA406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		10 / 12 PHE A 131
CYH A 132
MET A 176
GLU A 180
PRO A 181
SER A 213
HIS A 235
VAL A 280
TRP A 311
ASN A 312
 5AD  A 503 (-4.6A)
SF4  A 502 ( 2.2A)
A  C  37 ( 3.7A)
MET  A 501 (-4.0A)
MET  A 501 ( 4.9A)
MET  A 501 ( 3.3A)
5AD  A 503 (-3.7A)
5AD  A 503 (-4.8A)
5AD  A 503 (-4.0A)
SMC  A 355 (-3.7A)
 0.76A 3rfaA-5hr6A:
50.5		 3rfaA-5hr6A:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RFA_A_SAMA406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		9 / 12 PHE A 131
CYH A 132
MET A 176
HIS A 235
GLU A 278
VAL A 280
ILE A 309
TRP A 311
ASN A 312
 5AD  A 503 (-4.6A)
SF4  A 502 ( 2.2A)
A  C  37 ( 3.7A)
5AD  A 503 (-3.7A)
5AD  A 503 (-3.1A)
5AD  A 503 (-4.8A)
5AD  A 503 (-4.1A)
5AD  A 503 (-4.0A)
SMC  A 355 (-3.7A)
 0.92A 3rfaA-5hr6A:
50.5		 3rfaA-5hr6A:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RFA_B_SAMB406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		8 / 12 PHE A 131
CYH A 132
MET A 176
GLU A 180
PRO A 181
SER A 211
SER A 213
TRP A 311
 5AD  A 503 (-4.6A)
SF4  A 502 ( 2.2A)
A  C  37 ( 3.7A)
MET  A 501 (-4.0A)
MET  A 501 ( 4.9A)
MET  A 501 (-2.5A)
MET  A 501 ( 3.3A)
5AD  A 503 (-4.0A)
 0.58A 3rfaB-5hr6A:
52.8		 3rfaB-5hr6A:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RFA_B_SAMB406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		11 / 12 PHE A 131
CYH A 132
MET A 176
GLU A 180
PRO A 181
SER A 211
SER A 233
HIS A 235
VAL A 280
TRP A 311
ASN A 312
 5AD  A 503 (-4.6A)
SF4  A 502 ( 2.2A)
A  C  37 ( 3.7A)
MET  A 501 (-4.0A)
MET  A 501 ( 4.9A)
MET  A 501 (-2.5A)
MET  A 501 ( 2.6A)
5AD  A 503 (-3.7A)
5AD  A 503 (-4.8A)
5AD  A 503 (-4.0A)
SMC  A 355 (-3.7A)
 0.31A 3rfaB-5hr6A:
52.8		 3rfaB-5hr6A:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		3 / 3 PHE A 131
SER A 213
SER A 233
 5AD  A 503 (-4.6A)
MET  A 501 ( 3.3A)
MET  A 501 ( 2.6A)
 0.95A 3ufgB-5hr6A:
undetectable		 3ufgB-5hr6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		5 / 11 CYH A 132
GLU A 180
SER A 233
VAL A 280
ILE A 309
 SF4  A 502 ( 2.2A)
MET  A 501 (-4.0A)
MET  A 501 ( 2.6A)
5AD  A 503 (-4.8A)
5AD  A 503 (-4.1A)
 0.52A 4k37A-5hr6A:
4.2		 4k37A-5hr6A:
19.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PL1_A_SAMA401_0
(DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		10 / 11 PHE A 131
MET A 176
GLU A 180
PRO A 181
SER A 211
SER A 233
HIS A 235
ILE A 309
TRP A 311
ASN A 312
 5AD  A 503 (-4.6A)
A  C  37 ( 3.7A)
MET  A 501 (-4.0A)
MET  A 501 ( 4.9A)
MET  A 501 (-2.5A)
MET  A 501 ( 2.6A)
5AD  A 503 (-3.7A)
5AD  A 503 (-4.1A)
5AD  A 503 (-4.0A)
SMC  A 355 (-3.7A)
 0.46A 4pl1A-5hr6A:
49.5		 4pl1A-5hr6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PL1_A_SAMA401_0
(DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		7 / 11 PHE A 131
MET A 176
HIS A 235
GLU A 278
ILE A 309
TRP A 311
ASN A 312
 5AD  A 503 (-4.6A)
A  C  37 ( 3.7A)
5AD  A 503 (-3.7A)
5AD  A 503 (-3.1A)
5AD  A 503 (-4.1A)
5AD  A 503 (-4.0A)
SMC  A 355 (-3.7A)
 0.88A 4pl1A-5hr6A:
49.5		 4pl1A-5hr6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PL1_B_SAMB401_0
(DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		9 / 10 CYH A 132
MET A 176
GLU A 180
PRO A 181
SER A 211
SER A 233
HIS A 235
TRP A 311
ASN A 312
 SF4  A 502 ( 2.2A)
A  C  37 ( 3.7A)
MET  A 501 (-4.0A)
MET  A 501 ( 4.9A)
MET  A 501 (-2.5A)
MET  A 501 ( 2.6A)
5AD  A 503 (-3.7A)
5AD  A 503 (-4.0A)
SMC  A 355 (-3.7A)
 0.41A 4pl1B-5hr6A:
51.9		 4pl1B-5hr6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PL1_B_SAMB401_0
(DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		7 / 10 CYH A 132
MET A 176
SER A 233
HIS A 235
GLU A 278
TRP A 311
ASN A 312
 SF4  A 502 ( 2.2A)
A  C  37 ( 3.7A)
MET  A 501 ( 2.6A)
5AD  A 503 (-3.7A)
5AD  A 503 (-3.1A)
5AD  A 503 (-4.0A)
SMC  A 355 (-3.7A)
 0.85A 4pl1B-5hr6A:
51.9		 4pl1B-5hr6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		4 / 5 LEU A 230
VAL A 188
VAL A 173
ARG A  25
 None
 1.11A 4r7iA-5hr6A:
undetectable		 4r7iA-5hr6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		3 / 3 SER A 213
SER A 211
PHE A 131
 MET  A 501 ( 3.3A)
MET  A 501 (-2.5A)
5AD  A 503 (-4.6A)
 0.94A 5mugA-5hr6A:
3.8		 5mugA-5hr6A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		3 / 3 LEU A  23
LEU A  21
TRP A 153
 None
 0.92A 5nwuA-5hr6A:
undetectable		 5nwuA-5hr6A:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		4 / 5 ASN A  19
ASP A  22
SER A 146
ARG A 144
 None
 1.48A 5w4zA-5hr6A:
5.2		 5w4zA-5hr6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		4 / 6 PHE A 330
LEU A 298
LEU A 295
HIS A 291
 None
 0.81A 6e43A-5hr6A:
undetectable		 6e43A-5hr6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		4 / 6 PHE A 330
LEU A 298
LEU A 295
HIS A 291
 None
 0.90A 6e43B-5hr6A:
undetectable		 6e43B-5hr6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		4 / 6 PHE A 330
LEU A 298
LEU A 295
HIS A 291
 None
 0.79A 6e43C-5hr6A:
undetectable		 6e43C-5hr6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		4 / 6 PHE A 330
LEU A 298
LEU A 295
HIS A 291
 None
 0.91A 6e43D-5hr6A:
undetectable		 6e43D-5hr6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_B_ACTB706_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		4 / 5 HIS A 235
VAL A 246
PHE A 257
ARG A 242
 5AD  A 503 (-3.7A)
None
None
None
 1.37A 6hxiB-5hr6A:
undetectable		 6hxiB-5hr6A:
21.68