SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hra'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 5hra ASPARTATE/GLUTAMATE
RACEMASE
(Escherichia
coli) 		4 / 7 PHE A  45
ILE A 157
ILE A 161
THR A  85
 None
None
None
DAS  A 301 (-3.7A)
 1.00A 1sbrB-5hraA:
undetectable		 1sbrB-5hraA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5hra ASPARTATE/GLUTAMATE
RACEMASE
(Escherichia
coli) 		6 / 11 ILE A 182
ALA A 186
ALA A 190
GLN A 188
LEU A 147
ILE A 200
 None
 1.20A 2aclE-5hraA:
undetectable		 2aclE-5hraA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 5hra ASPARTATE/GLUTAMATE
RACEMASE
(Escherichia
coli) 		6 / 12 ILE A 104
ALA A 107
ARG A 110
ALA A 224
LEU A 102
ILE A  22
 None
 1.47A 2h79A-5hraA:
undetectable		 2h79A-5hraA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 5hra ASPARTATE/GLUTAMATE
RACEMASE
(Escherichia
coli) 		4 / 7 VAL A  89
LYS A  88
LYS A  59
GLU A  56
 None
 1.25A 3hs4A-5hraA:
undetectable		 3hs4A-5hraA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5hra ASPARTATE/GLUTAMATE
RACEMASE
(Escherichia
coli) 		5 / 12 ILE A 104
ALA A 107
ARG A 110
ALA A 224
ILE A  22
 None
 1.12A 4lnwA-5hraA:
undetectable		 4lnwA-5hraA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5hra ASPARTATE/GLUTAMATE
RACEMASE
(Escherichia
coli) 		5 / 12 ILE A 104
ALA A 107
ARG A 110
ALA A 224
ILE A  22
 None
 1.14A 4lnxA-5hraA:
undetectable		 4lnxA-5hraA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA907_0
(PROTEIN ARGONAUTE-2)		 5hra ASPARTATE/GLUTAMATE
RACEMASE
(Escherichia
coli) 		4 / 5 LYS A  88
THR A 125
THR A  85
TYR A 127
 None
DAS  A 301 ( 4.1A)
DAS  A 301 (-3.7A)
None
 1.46A 4w5oA-5hraA:
2.2		 4w5oA-5hraA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5hra ASPARTATE/GLUTAMATE
RACEMASE
(Escherichia
coli) 		4 / 6 LYS A  88
THR A 125
THR A  85
TYR A 127
 None
DAS  A 301 ( 4.1A)
DAS  A 301 (-3.7A)
None
 1.48A 4w5tA-5hraA:
3.6		 4w5tA-5hraA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5hra ASPARTATE/GLUTAMATE
RACEMASE
(Escherichia
coli) 		4 / 6 LYS A  88
THR A 125
THR A  85
TYR A 127
 None
DAS  A 301 ( 4.1A)
DAS  A 301 (-3.7A)
None
 1.45A 4z4cA-5hraA:
2.2		 4z4cA-5hraA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5hra ASPARTATE/GLUTAMATE
RACEMASE
(Escherichia
coli) 		4 / 5 LYS A  88
THR A 125
THR A  85
TYR A 127
 None
DAS  A 301 ( 4.1A)
DAS  A 301 (-3.7A)
None
 1.47A 4z4dA-5hraA:
2.2		 4z4dA-5hraA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA907_0
(PROTEIN ARGONAUTE-2)		 5hra ASPARTATE/GLUTAMATE
RACEMASE
(Escherichia
coli) 		4 / 5 LYS A  88
THR A 125
THR A  85
TYR A 127
 None
DAS  A 301 ( 4.1A)
DAS  A 301 (-3.7A)
None
 1.47A 4z4eA-5hraA:
3.8		 4z4eA-5hraA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5hra ASPARTATE/GLUTAMATE
RACEMASE
(Escherichia
coli) 		4 / 6 LYS A  88
THR A 125
THR A  85
TYR A 127
 None
DAS  A 301 ( 4.1A)
DAS  A 301 (-3.7A)
None
 1.48A 4z4fA-5hraA:
2.2		 4z4fA-5hraA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5hra ASPARTATE/GLUTAMATE
RACEMASE
(Escherichia
coli) 		5 / 9 ILE A  48
GLY A   9
THR A  15
LEU A   7
LEU A  40
 None
 1.48A 5fhzB-5hraA:
undetectable		 5fhzB-5hraA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 5hra ASPARTATE/GLUTAMATE
RACEMASE
(Escherichia
coli) 		5 / 12 TYR A  18
LEU A  81
LEU A  64
PHE A  45
THR A 198
 None
None
None
None
DAS  A 301 (-3.2A)
 1.35A 5ieoA-5hraA:
undetectable		 5ieoA-5hraA:
19.20