SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hrm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 9 VAL A 149
GLY A 563
THR A 522
ILE A 131
SER A 525
 None
 1.33A 1gtnL-5hrmA:
undetectable
1gtnM-5hrmA:
undetectable		 1gtnL-5hrmA:
9.68
1gtnM-5hrmA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 10 GLY A 271
HIS A 286
THR A 202
HIS A 258
ALA A 232
 None
None
None
MN  A 602 (-3.2A)
None
 1.26A 1gtnO-5hrmA:
undetectable
1gtnP-5hrmA:
undetectable		 1gtnO-5hrmA:
9.68
1gtnP-5hrmA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 8 MET A 203
ARG A 192
LEU A 190
GLY A 136
 None
 1.01A 1hrkA-5hrmA:
undetectable		 1hrkA-5hrmA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 6 ARG A 226
ILE A 223
GLY A 222
ALA A 231
 None
 1.00A 1wmqA-5hrmA:
undetectable		 1wmqA-5hrmA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 6 ARG A 226
ILE A 223
GLY A 222
ALA A 231
 None
 1.00A 1wmqB-5hrmA:
undetectable		 1wmqB-5hrmA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 6 ARG A 226
ILE A 223
GLY A 222
ALA A 231
 None
 1.00A 1wrqA-5hrmA:
undetectable		 1wrqA-5hrmA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 6 ARG A 226
ILE A 223
GLY A 222
ALA A 231
 None
 1.00A 1wrqB-5hrmA:
undetectable		 1wrqB-5hrmA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 12 HIS A 317
LEU A 435
LEU A 408
GLY A 409
ALA A 494
 MN  A 602 (-3.2A)
None
None
None
None
 1.17A 2kceB-5hrmA:
undetectable		 2kceB-5hrmA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 8 ASN A 365
VAL A 369
TYR A 329
ASN A 265
 None
 1.25A 2wekB-5hrmA:
undetectable		 2wekB-5hrmA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 12 PHE A 557
ALA A 558
THR A 129
GLY A 135
LEU A 534
 None
 1.35A 3aodC-5hrmA:
undetectable		 3aodC-5hrmA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 9 LEU A 502
VAL A 399
ILE A 429
ALA A 394
ILE A 396
 None
 1.03A 3el0B-5hrmA:
undetectable		 3el0B-5hrmA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		3 / 3 ASP A 289
ARG A 297
ARG A 211
 None
 0.98A 3k37A-5hrmA:
2.4		 3k37A-5hrmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		3 / 3 LYS A 428
VAL A 430
HIS A 401
 None
 1.12A 3tj7A-5hrmA:
undetectable		 3tj7A-5hrmA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 5 SER A 345
ASP A 350
ASP A 454
ILE A 462
 None
 1.33A 3uj7B-5hrmA:
undetectable		 3uj7B-5hrmA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 8 VAL A 274
HIS A 317
PRO A 157
TRP A 531
 None
MN  A 602 (-3.2A)
None
None
 1.37A 3v35A-5hrmA:
undetectable		 3v35A-5hrmA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 6 PHE A 557
LEU A 489
PRO A 491
SER A 544
 None
 1.30A 3vlnA-5hrmA:
undetectable		 3vlnA-5hrmA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 4 HIS A 317
GLU A 273
HIS A 286
LEU A 234
 MN  A 602 (-3.2A)
None
None
None
 1.27A 4m2rA-5hrmA:
undetectable		 4m2rA-5hrmA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 6 LEU A 347
HIS A 258
HIS A 317
GLU A 201
 None
MN  A 602 (-3.2A)
MN  A 602 (-3.2A)
MN  A 602 ( 2.5A)
 0.98A 4pahA-5hrmA:
undetectable		 4pahA-5hrmA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 4 ASN A 308
ILE A 362
TYR A 361
PHE A 302
 None
 1.12A 5igvA-5hrmA:
0.2		 5igvA-5hrmA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 10 PHE A 433
ILE A 499
GLY A 495
GLY A 496
GLU A  98
 None
 1.16A 5lbtA-5hrmA:
undetectable
5lbtB-5hrmA:
undetectable		 5lbtA-5hrmA:
17.13
5lbtB-5hrmA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 12 VAL A 275
HIS A 258
THR A 151
ARG A 226
GLY A 156
 None
MN  A 602 (-3.2A)
None
None
None
 1.30A 5m50B-5hrmA:
undetectable		 5m50B-5hrmA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 12 VAL A 275
HIS A 258
THR A 151
ARG A 226
GLY A 156
 None
MN  A 602 (-3.2A)
None
None
None
 1.31A 5m50E-5hrmA:
undetectable		 5m50E-5hrmA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 4 GLY A 473
ALA A 494
MET A 543
THR A 539
 None
 1.19A 5n0sB-5hrmA:
undetectable		 5n0sB-5hrmA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 12 ALA A 330
GLU A 424
LEU A 402
ILE A 419
ASP A 423
 None
 1.28A 5vlmG-5hrmA:
undetectable		 5vlmG-5hrmA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 12 LEU A 402
GLY A 387
PRO A 427
ILE A 421
ILE A 419
 None
 0.86A 6dh3A-5hrmA:
undetectable		 6dh3A-5hrmA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 8 HIS A 554
ARG A 124
HIS A 120
GLU A 568
 None
 1.19A 6mn4A-5hrmA:
undetectable		 6mn4A-5hrmA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 8 HIS A 554
ARG A 124
HIS A 120
GLU A 568
 None
 1.08A 6mn4B-5hrmA:
undetectable		 6mn4B-5hrmA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5hrm HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 6 LEU A 347
HIS A 258
HIS A 317
GLU A 201
 None
MN  A 602 (-3.2A)
MN  A 602 (-3.2A)
MN  A 602 ( 2.5A)
 0.92A 6pahA-5hrmA:
undetectable		 6pahA-5hrmA:
21.16