SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hrz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5hrz TPR DOMAIN PROTEIN
1NA0C3_3
(synthetic
construct) 		4 / 8 TYR A  48
TYR A  75
TYR A  41
TYR A  14
 None
 1.20A 3po7A-5hrzA:
undetectable		 3po7A-5hrzA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5hrz TPR DOMAIN PROTEIN
1NA0C3_3
(synthetic
construct) 		4 / 8 ALA A  56
ALA A  73
ALA A  63
ALA A  59
 None
 0.72A 4twdF-5hrzA:
undetectable
4twdG-5hrzA:
undetectable
4twdH-5hrzA:
undetectable
4twdI-5hrzA:
undetectable
4twdJ-5hrzA:
undetectable		 4twdF-5hrzA:
14.71
4twdG-5hrzA:
14.71
4twdH-5hrzA:
14.71
4twdI-5hrzA:
14.71
4twdJ-5hrzA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5hrz TPR DOMAIN PROTEIN
1NA0C3_3
(synthetic
construct) 		4 / 8 ALA A  63
ALA A  59
ALA A  56
ALA A  73
 None
 0.77A 4twdF-5hrzA:
undetectable
4twdG-5hrzA:
undetectable
4twdH-5hrzA:
undetectable
4twdI-5hrzA:
undetectable
4twdJ-5hrzA:
undetectable		 4twdF-5hrzA:
14.71
4twdG-5hrzA:
14.71
4twdH-5hrzA:
14.71
4twdI-5hrzA:
14.71
4twdJ-5hrzA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5hrz TPR DOMAIN PROTEIN
1NA0C3_3
(synthetic
construct) 		4 / 8 ALA A  73
ALA A  63
ALA A  59
ALA A  56
 None
 0.74A 4twdF-5hrzA:
undetectable
4twdG-5hrzA:
undetectable
4twdH-5hrzA:
undetectable
4twdI-5hrzA:
undetectable
4twdJ-5hrzA:
undetectable		 4twdF-5hrzA:
14.71
4twdG-5hrzA:
14.71
4twdH-5hrzA:
14.71
4twdI-5hrzA:
14.71
4twdJ-5hrzA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5hrz TPR DOMAIN PROTEIN
1NA0C3_3
(synthetic
construct) 		4 / 8 ALA A  73
ALA A  63
ALA A  59
ALA A  56
 None
 0.79A 4twdF-5hrzA:
undetectable
4twdG-5hrzA:
undetectable
4twdH-5hrzA:
undetectable
4twdI-5hrzA:
undetectable
4twdJ-5hrzA:
undetectable		 4twdF-5hrzA:
14.71
4twdG-5hrzA:
14.71
4twdH-5hrzA:
14.71
4twdI-5hrzA:
14.71
4twdJ-5hrzA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 5hrz TPR DOMAIN PROTEIN
1NA0C3_3
(synthetic
construct) 		3 / 3 ASP A  88
LEU A 120
GLY A 119
 None
 0.50A 4xmfA-5hrzA:
undetectable		 4xmfA-5hrzA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 5hrz TPR DOMAIN PROTEIN
1NA0C3_3
(synthetic
construct) 		4 / 6 TYR A  41
TYR A  60
ASP A  67
TYR A  14
 None
 1.31A 5ov9A-5hrzA:
undetectable		 5ov9A-5hrzA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 5hrz TPR DOMAIN PROTEIN
1NA0C3_3
(synthetic
construct) 		4 / 7 TYR A  41
TYR A  60
ASP A  67
TYR A  14
 None
 1.40A 5ov9B-5hrzA:
undetectable		 5ov9B-5hrzA:
10.58