SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hs0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		4 / 5 GLU A  13
LEU A   7
LEU A  10
LEU A   8
 None
 1.14A 1np1A-5hs0A:
undetectable		 1np1A-5hs0A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 12 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.87A 2f80A-5hs0A:
undetectable		 2f80A-5hs0A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 12 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 1.00A 2f80B-5hs0A:
undetectable		 2f80B-5hs0A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 12 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.89A 2f81A-5hs0A:
undetectable		 2f81A-5hs0A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 12 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.88A 2f8gA-5hs0A:
undetectable		 2f8gA-5hs0A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 12 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.94A 2hs2A-5hs0A:
undetectable		 2hs2A-5hs0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 12 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.92A 2hs2B-5hs0A:
undetectable		 2hs2B-5hs0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 12 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.86A 2ieoA-5hs0A:
undetectable		 2ieoA-5hs0A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 11 LEU A  23
ILE A  16
ALA A  17
GLU A  46
LEU A  56
 None
 1.17A 2v0mD-5hs0A:
undetectable		 2v0mD-5hs0A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		3 / 3 SER A  33
HIS A  75
ASP A  95
 None
 0.72A 2wa2B-5hs0A:
undetectable		 2wa2B-5hs0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 12 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.92A 3cywA-5hs0A:
undetectable		 3cywA-5hs0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 11 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.94A 3el1A-5hs0A:
undetectable		 3el1A-5hs0A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 12 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.96A 3lzsA-5hs0A:
undetectable		 3lzsA-5hs0A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 12 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.97A 3lzuA-5hs0A:
undetectable		 3lzuA-5hs0A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 10 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.93A 3lzvA-5hs0A:
undetectable		 3lzvA-5hs0A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 12 LEU A 121
GLY A 126
ALA A 127
ASP A 128
LEU A 122
 None
 0.69A 3ogqB-5hs0A:
undetectable		 3ogqB-5hs0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 10 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 1.01A 3oxwA-5hs0A:
undetectable		 3oxwA-5hs0A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 10 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.89A 3oxwC-5hs0A:
undetectable		 3oxwC-5hs0A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 12 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.94A 3oxxC-5hs0A:
undetectable		 3oxxC-5hs0A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 10 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.94A 3oy4B-5hs0A:
undetectable		 3oy4B-5hs0A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 12 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.91A 3pwmB-5hs0A:
undetectable		 3pwmB-5hs0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 12 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.99A 3tkwA-5hs0A:
undetectable		 3tkwA-5hs0A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 12 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.88A 3ucbA-5hs0A:
undetectable		 3ucbA-5hs0A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 12 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.87A 3ucbB-5hs0A:
undetectable		 3ucbB-5hs0A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 10 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.94A 4dqbB-5hs0A:
undetectable		 4dqbB-5hs0A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 10 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.94A 4dqeB-5hs0A:
undetectable		 4dqeB-5hs0A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 10 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.94A 4dqhB-5hs0A:
undetectable		 4dqhB-5hs0A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		4 / 6 LYS A 120
ILE A 123
VAL A 129
LEU A 107
 None
 1.01A 4em2A-5hs0A:
undetectable		 4em2A-5hs0A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 12 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.98A 4hlaA-5hs0A:
undetectable		 4hlaA-5hs0A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 11 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.97A 4hlaB-5hs0A:
undetectable		 4hlaB-5hs0A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 9 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.94A 4q1wA-5hs0A:
undetectable		 4q1wA-5hs0A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 10 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.93A 4q1yA-5hs0A:
undetectable		 4q1yA-5hs0A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_A_BEZA601_0
(EUGENOL OXIDASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 9 VAL A 119
GLN A 158
ILE A 123
VAL A 129
LEU A 159
 None
 1.41A 5fxfA-5hs0A:
undetectable		 5fxfA-5hs0A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_B_BEZB601_0
(EUGENOL OXIDASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 10 VAL A 119
GLN A 158
ILE A 123
VAL A 129
LEU A 159
 None
 1.40A 5fxfB-5hs0A:
undetectable		 5fxfB-5hs0A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		4 / 4 ASP A  69
SER A  68
ASP A  67
HIS A  42
 None
 1.41A 5wyqB-5hs0A:
undetectable		 5wyqB-5hs0A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		4 / 4 ASP A  69
SER A  68
ASP A  67
HIS A  76
 None
 0.99A 5wyqB-5hs0A:
undetectable		 5wyqB-5hs0A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		4 / 4 ASP A 102
SER A 101
ASP A 100
HIS A  75
 None
 1.38A 5wyqB-5hs0A:
undetectable		 5wyqB-5hs0A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		4 / 4 ASP A 102
SER A 101
ASP A 100
HIS A 109
 None
 1.10A 5wyqB-5hs0A:
undetectable		 5wyqB-5hs0A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		4 / 4 ASP A 135
SER A 134
ASP A 133
HIS A 108
 None
 1.42A 5wyqB-5hs0A:
undetectable		 5wyqB-5hs0A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_0
(PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 12 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.90A 6dgxA-5hs0A:
undetectable		 6dgxA-5hs0A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 12 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.93A 6dh0A-5hs0A:
undetectable		 6dh0A-5hs0A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7
(synthetic
construct) 		5 / 12 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
 None
 0.94A 6dh6A-5hs0A:
undetectable		 6dh6A-5hs0A:
16.56