SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hs1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 473
TYR A 477
PHE A 463
PRO A 462
 None
None
HEM  A 601 (-4.4A)
None
 1.16A 1dfoB-5hs1A:
undetectable		 1dfoB-5hs1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 473
TYR A 477
PHE A 463
PRO A 462
 None
None
HEM  A 601 (-4.4A)
None
 1.16A 1dfoA-5hs1A:
undetectable		 1dfoA-5hs1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 473
TYR A 477
PHE A 463
PRO A 462
 None
None
HEM  A 601 (-4.4A)
None
 1.17A 1dfoD-5hs1A:
undetectable		 1dfoD-5hs1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 473
TYR A 477
PHE A 463
PRO A 462
 None
None
HEM  A 601 (-4.4A)
None
 1.16A 1dfoC-5hs1A:
undetectable		 1dfoC-5hs1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A  54
ARG A  52
ASP A 390
 None
 0.82A 1vptA-5hs1A:
undetectable		 1vptA-5hs1A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 366
GLY A 481
LEU A 355
ILE A 486
 None
 0.81A 1yajF-5hs1A:
undetectable		 1yajF-5hs1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 373
ILE A 194
ASP A 195
ALA A 517
PHE A 487
 None
 1.06A 2admA-5hs1A:
undetectable		 2admA-5hs1A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 473
TYR A 477
PHE A 463
PRO A 462
 None
None
HEM  A 601 (-4.4A)
None
 1.32A 2vmyA-5hs1A:
undetectable		 2vmyA-5hs1A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 126
TYR A 140
THR A 318
LEU A 380
VAL A 510
 VOR  A 602 ( 3.8A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
 0.92A 2wuzA-5hs1A:
40.0		 2wuzA-5hs1A:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 126
TYR A 140
THR A 318
LEU A 380
VAL A 510
 VOR  A 602 ( 3.8A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
 0.92A 2wuzB-5hs1A:
40.0		 2wuzB-5hs1A:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 134
TYR A 140
THR A 318
LEU A 380
 VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.51A 2wx2A-5hs1A:
38.0		 2wx2A-5hs1A:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 8 TYR A 126
PHE A 134
TYR A 140
THR A 318
LEU A 380
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.40A 2wx2B-5hs1A:
36.5		 2wx2B-5hs1A:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 126
PHE A 241
TYR A 140
PRO A 238
THR A 318
 VOR  A 602 ( 3.8A)
None
HEM  A 601 (-4.3A)
None
HEM  A 601 (-3.4A)
 1.31A 2x2nA-5hs1A:
39.3		 2x2nA-5hs1A:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 126
PHE A 241
TYR A 140
LEU A 380
MET A 509
 VOR  A 602 ( 3.8A)
None
HEM  A 601 (-4.3A)
VOR  A 602 (-4.0A)
VOR  A 602 ( 4.2A)
 1.20A 2x2nD-5hs1A:
39.6		 2x2nD-5hs1A:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 126
PHE A 241
TYR A 140
THR A 318
LEU A 380
 VOR  A 602 ( 3.8A)
None
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.96A 2x2nD-5hs1A:
39.6		 2x2nD-5hs1A:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 194
TYR A 177
MET A 203
THR A 204
 None
 1.41A 3abkN-5hs1A:
undetectable
3abkW-5hs1A:
undetectable		 3abkN-5hs1A:
22.64
3abkW-5hs1A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 184
GLU A 522
ILE A 519
TRP A 493
 None
 1.34A 3e7gA-5hs1A:
undetectable
3e7gB-5hs1A:
undetectable		 3e7gA-5hs1A:
21.57
3e7gB-5hs1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 218
SER A 267
ASP A 301
ILE A 304
LEU A 308
 None
 1.35A 3iv6C-5hs1A:
undetectable		 3iv6C-5hs1A:
19.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 8 TYR A 126
THR A 130
TYR A 140
GLY A 310
THR A 318
 VOR  A 602 ( 3.8A)
None
HEM  A 601 (-4.3A)
VOR  A 602 (-4.3A)
HEM  A 601 (-3.4A)
 0.59A 3jusA-5hs1A:
45.4		 3jusA-5hs1A:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 8 TYR A 126
THR A 130
TYR A 140
GLY A 310
THR A 318
 VOR  A 602 ( 3.8A)
None
HEM  A 601 (-4.3A)
VOR  A 602 (-4.3A)
HEM  A 601 (-3.4A)
 0.59A 3jusA-5hs1A:
45.4		 3jusA-5hs1A:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 9 TYR A 126
THR A 130
TYR A 140
GLY A 310
THR A 318
 VOR  A 602 ( 3.8A)
None
HEM  A 601 (-4.3A)
VOR  A 602 (-4.3A)
HEM  A 601 (-3.4A)
 0.49A 3jusB-5hs1A:
45.0		 3jusB-5hs1A:
35.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 134
TYR A 140
THR A 318
LEU A 380
 VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.51A 3khmA-5hs1A:
39.3		 3khmA-5hs1A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 126
TYR A 140
THR A 318
LEU A 380
 VOR  A 602 ( 3.8A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.66A 3khmA-5hs1A:
39.3		 3khmA-5hs1A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_B_TPFB490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 9 TYR A 126
TYR A 140
THR A 318
LEU A 380
MET A 509
 VOR  A 602 ( 3.8A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
VOR  A 602 ( 4.2A)
 1.19A 3l4dB-5hs1A:
39.8		 3l4dB-5hs1A:
28.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 9 TYR A 126
PHE A 134
TYR A 140
THR A 318
LEU A 380
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.92A 3l4dC-5hs1A:
39.4		 3l4dC-5hs1A:
28.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 9 TYR A 126
TYR A 140
THR A 318
LEU A 380
MET A 509
 VOR  A 602 ( 3.8A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
VOR  A 602 ( 4.2A)
 1.08A 3l4dC-5hs1A:
39.4		 3l4dC-5hs1A:
28.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 12 TYR A 126
PHE A 134
TYR A 140
GLY A 310
THR A 318
MET A 509
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 ( 4.2A)
 0.59A 3ld6A-5hs1A:
45.6		 3ld6A-5hs1A:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 12 TYR A 126
PHE A 134
TYR A 140
PHE A 236
GLY A 310
THR A 318
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-4.3A)
HEM  A 601 (-3.4A)
 0.74A 3ld6A-5hs1A:
45.6		 3ld6A-5hs1A:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 134
TYR A 140
GLY A 310
THR A 318
MET A 509
 VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 ( 4.2A)
 0.59A 3ld6B-5hs1A:
45.4		 3ld6B-5hs1A:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 12 TYR A 126
PHE A 134
TYR A 140
PHE A 236
GLY A 310
THR A 318
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-4.3A)
HEM  A 601 (-3.4A)
 0.75A 3ld6B-5hs1A:
45.4		 3ld6B-5hs1A:
35.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLL_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 10 MET A 217
LEU A 213
LEU A 212
MET A 288
LEU A 287
 None
 1.49A 3ollA-5hs1A:
undetectable		 3ollA-5hs1A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 111
TYR A 404
LEU A 117
LYS A 116
 None
 1.20A 3sudD-5hs1A:
undetectable		 3sudD-5hs1A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 404
LEU A 117
LYS A 116
 None
 0.62A 3sueD-5hs1A:
undetectable		 3sueD-5hs1A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 8 GLU A  81
GLU A  78
TYR A  77
ARG A 416
 None
 0.86A 4fgzA-5hs1A:
undetectable
4fgzB-5hs1A:
undetectable		 4fgzA-5hs1A:
21.13
4fgzB-5hs1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A  54
ARG A  52
ASP A 390
 None
 0.82A 4fzvA-5hs1A:
undetectable		 4fzvA-5hs1A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 108
VAL A 112
PRO A 410
LEU A 461
ILE A 452
 None
 1.05A 4pd4C-5hs1A:
undetectable		 4pd4C-5hs1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		3 / 3 MET A 299
GLU A 303
LEU A 307
 None
 0.39A 4v2oB-5hs1A:
undetectable		 4v2oB-5hs1A:
9.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WMZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 9 TYR A 126
ILE A 139
TYR A 140
THR A 318
LEU A 380
MET A 509
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
VOR  A 602 ( 4.2A)
 0.88A 4wmzA-5hs1A:
63.3		 4wmzA-5hs1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WMZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		8 / 9 TYR A 126
PHE A 134
ILE A 139
TYR A 140
PHE A 236
GLY A 314
THR A 318
LEU A 380
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.41A 4wmzA-5hs1A:
63.3		 4wmzA-5hs1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 456
ILE A 452
HIS A 378
LEU A 383
 None
None
HEM  A 601 ( 4.9A)
HEM  A 601 (-4.0A)
 1.18A 4xo7B-5hs1A:
undetectable		 4xo7B-5hs1A:
20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 12 GLY A  73
GLY A 315
THR A 318
LEU A 380
HIS A 381
THR A 507
 None
HEM  A 601 (-3.5A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
None
 0.77A 4zdyA-5hs1A:
63.6		 4zdyA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 GLY A  73
TYR A 126
PHE A 134
ILE A 139
PHE A 236
GLY A 314
THR A 318
LEU A 380
HIS A 381
PHE A 384
THR A 507
 None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
None
None
 0.50A 4zdyA-5hs1A:
63.6		 4zdyA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 12 TYR A 126
ILE A 139
THR A 318
LEU A 380
THR A 507
MET A 509
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
VOR  A 602 ( 4.2A)
 1.38A 4zdyA-5hs1A:
63.6		 4zdyA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
TYR A  72
PRO A 238
 None
 0.37A 4zdyA-5hs1A:
63.6		 4zdyA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 7 PHE A 134
ILE A 139
PHE A 236
GLY A 314
THR A 318
LEU A 380
 VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.39A 4zdzA-5hs1A:
63.5		 4zdzA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		9 / 9 TYR A 126
THR A 130
PHE A 134
ILE A 139
PHE A 236
GLY A 314
THR A 318
LEU A 380
LEU A 383
 VOR  A 602 ( 3.8A)
None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
HEM  A 601 (-4.0A)
 0.44A 4ze0A-5hs1A:
63.6		 4ze0A-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  73
MET A  74
GLY A 315
LEU A 380
HIS A 381
 None
None
HEM  A 601 (-3.5A)
VOR  A 602 (-4.0A)
None
 0.62A 4ze1A-5hs1A:
63.7		 4ze1A-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 TYR A  72
GLY A  73
MET A  74
LEU A 129
PHE A 134
PHE A 236
GLY A 314
LEU A 380
HIS A 381
PHE A 384
THR A 507
 None
None
None
None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
VOR  A 602 (-4.0A)
None
None
None
 0.58A 4ze1A-5hs1A:
63.7		 4ze1A-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 5 VAL A  70
TYR A 126
ILE A 139
PRO A 238
THR A 318
 None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.3A)
None
HEM  A 601 (-3.4A)
 0.50A 4ze1A-5hs1A:
undetectable		 4ze1A-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 5 VAL A  71
TYR A 126
ILE A 139
PRO A 238
THR A 318
 None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.3A)
None
HEM  A 601 (-3.4A)
 1.32A 4ze1A-5hs1A:
undetectable		 4ze1A-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 12 GLY A  73
GLY A 315
THR A 318
LEU A 380
HIS A 381
THR A 507
 None
HEM  A 601 (-3.5A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
None
 0.78A 4ze2A-5hs1A:
63.4		 4ze2A-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 GLY A  73
TYR A 126
LEU A 129
PHE A 134
ILE A 139
PHE A 236
GLY A 314
THR A 318
LEU A 380
HIS A 381
THR A 507
 None
VOR  A 602 ( 3.8A)
None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
None
 0.60A 4ze2A-5hs1A:
63.4		 4ze2A-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 5 ALA A  69
TYR A  72
PRO A 238
PHE A 384
 None
 0.40A 4ze2A-5hs1A:
63.4		 4ze2A-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		7 / 7 TYR A 126
PHE A 134
ILE A 139
PHE A 236
GLY A 314
THR A 318
LEU A 380
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.45A 4ze3A-5hs1A:
63.3		 4ze3A-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  73
GLY A 315
LEU A 380
HIS A 381
THR A 507
 None
HEM  A 601 (-3.5A)
VOR  A 602 (-4.0A)
None
None
 0.47A 5eqbA-5hs1A:
63.2		 5eqbA-5hs1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 GLY A  73
PHE A 134
ILE A 139
TYR A 140
PHE A 236
GLY A 310
GLY A 314
LEU A 380
HIS A 381
PHE A 384
THR A 507
 None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-4.3A)
VOR  A 602 (-3.0A)
VOR  A 602 (-4.0A)
None
None
None
 0.55A 5eqbA-5hs1A:
63.2		 5eqbA-5hs1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EQB_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 4 TYR A  72
TYR A 126
PRO A 238
THR A 318
 None
VOR  A 602 ( 3.8A)
None
HEM  A 601 (-3.4A)
 0.36A 5eqbA-5hs1A:
63.2		 5eqbA-5hs1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 139
TYR A 140
VAL A 242
THR A 318
LEU A 380
MET A 509
 VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
None
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
VOR  A 602 ( 4.2A)
 1.42A 5esgA-5hs1A:
63.7		 5esgA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  72
GLY A 315
THR A 318
LEU A 380
HIS A 381
 None
HEM  A 601 (-3.5A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
 0.91A 5esgA-5hs1A:
63.7		 5esgA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		10 / 12 TYR A  72
PHE A 134
ILE A 139
TYR A 140
PHE A 236
VAL A 242
GLY A 314
THR A 318
LEU A 380
HIS A 381
 None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
None
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
 0.48A 5esgA-5hs1A:
63.7		 5esgA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 4 LEU A  96
TYR A 126
PRO A 238
ILE A 239
 None
VOR  A 602 ( 3.8A)
None
None
 0.36A 5esgA-5hs1A:
63.7		 5esgA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  69
LEU A  96
ILE A 139
TYR A 140
LEU A 383
 None
None
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
HEM  A 601 (-4.0A)
 1.10A 5eshA-5hs1A:
63.7		 5eshA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 ALA A  69
LEU A  96
TYR A 126
PHE A 134
ILE A 139
TYR A 140
PHE A 236
GLY A 314
THR A 318
LEU A 380
PHE A 384
 None
None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
 0.59A 5eshA-5hs1A:
63.7		 5eshA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 126
TYR A 140
THR A 318
LEU A 380
MET A 509
 VOR  A 602 ( 3.8A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
VOR  A 602 ( 4.2A)
 1.02A 5eshA-5hs1A:
63.7		 5eshA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 5 TYR A  72
LEU A 129
PRO A 238
LEU A 383
 None
None
None
HEM  A 601 (-4.0A)
 0.88A 5eshA-5hs1A:
63.7		 5eshA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 GLY A  73
TYR A 126
LEU A 129
PHE A 134
ILE A 139
TYR A 140
PHE A 236
GLY A 314
THR A 318
PHE A 384
THR A 507
 None
VOR  A 602 ( 3.8A)
None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
None
None
 0.47A 5eskA-5hs1A:
63.2		 5eskA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 129
TYR A 126
PHE A 236
GLY A 314
THR A 318
 None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
 1.19A 5eskA-5hs1A:
63.2		 5eskA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 4 ALA A  69
PRO A 238
LEU A 380
HIS A 381
 None
None
VOR  A 602 (-4.0A)
None
 0.58A 5eskA-5hs1A:
63.2		 5eskA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  73
GLY A 315
THR A 318
HIS A 381
THR A 507
 None
HEM  A 601 (-3.5A)
HEM  A 601 (-3.4A)
None
None
 0.84A 5eslA-5hs1A:
63.1		 5eslA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 GLY A  73
TYR A 126
PHE A 134
ILE A 139
TYR A 140
PHE A 236
GLY A 314
THR A 318
HIS A 381
PHE A 384
THR A 507
 None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
None
None
None
 0.49A 5eslA-5hs1A:
63.1		 5eslA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 5 ALA A  69
TYR A  72
PRO A 238
GLY A 310
LEU A 380
 None
None
None
VOR  A 602 (-4.3A)
VOR  A 602 (-4.0A)
 0.48A 5eslA-5hs1A:
63.1		 5eslA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		7 / 7 TYR A 126
PHE A 134
ILE A 139
PHE A 236
GLY A 314
THR A 318
LEU A 380
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.44A 5esmA-5hs1A:
63.8		 5esmA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 ALA A  69
TYR A  72
TYR A 126
LEU A 129
PHE A 134
ILE A 139
PHE A 236
GLY A 314
LEU A 380
HIS A 381
PHE A 384
 None
None
VOR  A 602 ( 3.8A)
None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
VOR  A 602 (-4.0A)
None
None
 0.67A 5fsaA-5hs1A:
55.8		 5fsaA-5hs1A:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 ALA A  69
TYR A  72
TYR A 126
LEU A 129
PHE A 134
ILE A 139
PHE A 236
PHE A 241
GLY A 314
HIS A 381
PHE A 384
 None
None
VOR  A 602 ( 3.8A)
None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
None
VOR  A 602 (-3.0A)
None
None
 0.63A 5fsaA-5hs1A:
55.8		 5fsaA-5hs1A:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  72
GLY A  73
GLY A 315
THR A 318
HIS A 381
 None
None
HEM  A 601 (-3.5A)
HEM  A 601 (-3.4A)
None
 0.86A 5fsaB-5hs1A:
54.7		 5fsaB-5hs1A:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		9 / 12 TYR A  72
GLY A  73
LEU A 129
PHE A 134
TYR A 140
GLY A 314
THR A 318
HIS A 381
PHE A 384
 None
None
None
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
None
None
 0.62A 5fsaB-5hs1A:
54.7		 5fsaB-5hs1A:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 12 TYR A  72
GLY A  73
TYR A 140
ILE A 471
HIS A 381
PHE A 384
 None
None
HEM  A 601 (-4.3A)
HEM  A 601 ( 4.9A)
None
None
 1.50A 5fsaB-5hs1A:
54.7		 5fsaB-5hs1A:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		9 / 12 TYR A  72
LEU A 129
PHE A 134
TYR A 140
PHE A 236
GLY A 314
THR A 318
HIS A 381
PHE A 384
 None
None
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
None
None
 0.64A 5fsaB-5hs1A:
54.7		 5fsaB-5hs1A:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  69
GLY A 315
THR A 318
HIS A 381
THR A 507
 None
HEM  A 601 (-3.5A)
HEM  A 601 (-3.4A)
None
None
 0.93A 5jlcA-5hs1A:
57.8		 5jlcA-5hs1A:
84.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 ALA A  69
TYR A 126
PHE A 134
ILE A 139
TYR A 140
PHE A 236
GLY A 314
THR A 318
HIS A 381
PHE A 384
THR A 507
 None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
None
None
None
 0.66A 5jlcA-5hs1A:
57.8		 5jlcA-5hs1A:
84.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 113
PRO A 410
PHE A 463
MET A 509
LEU A 407
 HEM  A 601 (-4.7A)
None
HEM  A 601 (-4.4A)
VOR  A 602 ( 4.2A)
None
 1.28A 5ljbA-5hs1A:
undetectable		 5ljbA-5hs1A:
12.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 134
TYR A 140
THR A 318
LEU A 380
THR A 507
 VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
 0.86A 5tl8A-5hs1A:
43.0		 5tl8A-5hs1A:
32.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 134
TYR A 126
PHE A 236
GLY A 314
THR A 318
 VOR  A 602 (-4.7A)
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
 1.13A 5v5zA-5hs1A:
54.1		 5v5zA-5hs1A:
64.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 126
ILE A 139
TYR A 140
PHE A 241
LEU A 383
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
None
HEM  A 601 (-4.0A)
 1.25A 5v5zA-5hs1A:
54.1		 5v5zA-5hs1A:
64.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 TYR A 126
PHE A 134
ILE A 139
TYR A 140
PHE A 236
PHE A 241
GLY A 314
THR A 318
LEU A 380
HIS A 381
PHE A 384
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
None
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
None
 0.53A 5v5zA-5hs1A:
54.1		 5v5zA-5hs1A:
64.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		3 / 3 GLY A  73
THR A 130
PRO A 238
 None
 0.34A 5v5zA-5hs1A:
54.1		 5v5zA-5hs1A:
64.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 170
ASN A 367
PHE A 487
LEU A 366
 None
 0.83A 5y7pC-5hs1A:
undetectable		 5y7pC-5hs1A:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 10 TYR A 126
PHE A 134
TYR A 140
PHE A 236
THR A 318
LEU A 380
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 1.37A 6ay4A-5hs1A:
42.8		 6ay4A-5hs1A:
32.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 10 TYR A 126
PHE A 134
TYR A 140
THR A 318
LEU A 380
CYH A 470
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
HEM  A 601 (-2.4A)
 0.71A 6ay4A-5hs1A:
42.8		 6ay4A-5hs1A:
32.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 9 TYR A 126
PHE A 134
TYR A 140
THR A 318
LEU A 380
CYH A 470
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
HEM  A 601 (-2.4A)
 0.49A 6ay6A-5hs1A:
42.6		 6ay6A-5hs1A:
32.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 126
PHE A 134
TYR A 140
THR A 318
LEU A 380
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.54A 6aybA-5hs1A:
42.8		 6aybA-5hs1A:
32.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  69
TYR A 126
PHE A 134
TYR A 140
LEU A 380
 None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.0A)
 1.08A 6aycA-5hs1A:
43.1		 6aycA-5hs1A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 126
PHE A 134
TYR A 140
THR A 318
LEU A 380
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.51A 6aycA-5hs1A:
43.1		 6aycA-5hs1A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 133
GLY A 235
ASP A 233
ASP A 231
 None
 1.28A 6cjkC-5hs1A:
undetectable		 6cjkC-5hs1A:
19.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 GLY A  73
TYR A 126
PHE A 134
ILE A 139
PHE A 236
GLY A 314
THR A 318
LEU A 380
HIS A 381
PHE A 384
THR A 507
 None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
None
None
 0.55A 6e8qA-5hs1A:
63.5		 6e8qA-5hs1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6E8Q_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 4 TYR A  72
LEU A 129
TYR A 140
PRO A 238
 None
None
HEM  A 601 (-4.3A)
None
 0.35A 6e8qA-5hs1A:
63.5		 6e8qA-5hs1A:
100.00