SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hsb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 5hsb RNA POLYMERASE
(Andes
orthohantavirus) 		5 / 11 PHE A  92
VAL A 135
ILE A 154
ILE A 101
PHE A 108
 None
 1.27A 1fkfA-5hsbA:
undetectable		 1fkfA-5hsbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 5hsb RNA POLYMERASE
(Andes
orthohantavirus) 		5 / 11 PHE A  92
VAL A 135
ILE A 154
ILE A 101
PHE A 108
 None
 1.25A 1fkjA-5hsbA:
undetectable		 1fkjA-5hsbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 5hsb RNA POLYMERASE
(Andes
orthohantavirus) 		5 / 11 PHE A  92
VAL A 135
ILE A 154
ILE A 101
PHE A 108
 None
 1.25A 1tcoC-5hsbA:
undetectable		 1tcoC-5hsbA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 5hsb RNA POLYMERASE
(Andes
orthohantavirus) 		5 / 11 PHE A  92
VAL A 135
ILE A 154
ILE A 101
PHE A 108
 None
 1.26A 2fkeA-5hsbA:
undetectable		 2fkeA-5hsbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 5hsb RNA POLYMERASE
(Andes
orthohantavirus) 		5 / 10 PHE A  92
VAL A 135
ILE A 154
ILE A 101
PHE A 108
 None
 1.19A 3ihzA-5hsbA:
undetectable		 3ihzA-5hsbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 5hsb RNA POLYMERASE
(Andes
orthohantavirus) 		5 / 12 ILE A 181
VAL A  39
ILE A 109
VAL A 159
VAL A 161
 None
 1.14A 3iw1A-5hsbA:
undetectable		 3iw1A-5hsbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 5hsb RNA POLYMERASE
(Andes
orthohantavirus) 		4 / 7 ASP A  97
ASP A  40
GLN A  41
GLU A  54
 MN  A 301 (-3.0A)
None
None
None
 1.18A 3l2vA-5hsbA:
undetectable		 3l2vA-5hsbA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 5hsb RNA POLYMERASE
(Andes
orthohantavirus) 		5 / 12 ASN A  50
VAL A  60
ILE A 106
ILE A 109
THR A  95
 None
 0.97A 3spkB-5hsbA:
undetectable		 3spkB-5hsbA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5hsb RNA POLYMERASE
(Andes
orthohantavirus) 		5 / 10 PHE A  92
VAL A 135
ILE A 154
ILE A 101
PHE A 108
 None
 1.27A 3uqaA-5hsbA:
undetectable		 3uqaA-5hsbA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 5hsb RNA POLYMERASE
(Andes
orthohantavirus) 		5 / 11 PHE A  92
VAL A 135
ILE A 154
ILE A 101
PHE A 108
 None
 1.29A 4drjA-5hsbA:
undetectable		 4drjA-5hsbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 5hsb RNA POLYMERASE
(Andes
orthohantavirus) 		5 / 10 PHE A  92
VAL A 135
ILE A 154
ILE A 101
PHE A 108
 None
 1.27A 4qt3A-5hsbA:
undetectable		 4qt3A-5hsbA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 5hsb RNA POLYMERASE
(Andes
orthohantavirus) 		5 / 11 PHE A  92
VAL A 135
ILE A 154
ILE A 101
PHE A 108
 None
 1.21A 5hw8D-5hsbA:
undetectable		 5hw8D-5hsbA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 5hsb RNA POLYMERASE
(Andes
orthohantavirus) 		5 / 11 PHE A  92
VAL A 135
ILE A 154
ILE A 101
PHE A 108
 None
 1.19A 5hw8G-5hsbA:
undetectable		 5hw8G-5hsbA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5hsb RNA POLYMERASE
(Andes
orthohantavirus) 		3 / 3 SER A  90
LEU A 138
MET A  74
 None
 0.67A 5ikrB-5hsbA:
undetectable		 5ikrB-5hsbA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5hsb RNA POLYMERASE
(Andes
orthohantavirus) 		5 / 12 PHE A  92
VAL A 135
ILE A 154
ILE A 101
PHE A 108
 None
 1.19A 6mkeA-5hsbA:
undetectable
6mkeD-5hsbA:
undetectable		 6mkeA-5hsbA:
18.42
6mkeD-5hsbA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5hsb RNA POLYMERASE
(Andes
orthohantavirus) 		5 / 12 PHE A  92
VAL A 135
ILE A 154
ILE A 101
PHE A 108
 None
 1.12A 6mkeB-5hsbA:
undetectable
6mkeC-5hsbA:
undetectable		 6mkeB-5hsbA:
18.42
6mkeC-5hsbA:
18.42