SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hsg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 ASP A 135
ILE A 137
GLY A 139
GLY A 249
TYR A 222
 None
 1.12A 1zz1C-5hsgA:
undetectable		 1zz1C-5hsgA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 LEU A  93
LEU A 284
SER A 286
ASP A 272
ALA A 278
 None
 1.12A 2br4F-5hsgA:
3.1		 2br4F-5hsgA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		5 / 5 LEU A  93
GLY A  91
PRO A 115
ILE A 287
ILE A 117
 None
 1.24A 2q9rA-5hsgA:
undetectable		 2q9rA-5hsgA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 GLY A 133
GLN A 271
PHE A  46
PHE A  47
 None
 0.92A 2qmzA-5hsgA:
4.4
2qmzB-5hsgA:
4.3		 2qmzA-5hsgA:
21.50
2qmzB-5hsgA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 GLY A 133
GLN A 271
PHE A  46
PHE A  47
 None
 0.96A 2qwxA-5hsgA:
5.8
2qwxB-5hsgA:
5.8		 2qwxA-5hsgA:
20.25
2qwxB-5hsgA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 GLY A 133
GLN A 271
PHE A  46
PHE A  47
 None
 0.99A 2qx4A-5hsgA:
4.2
2qx4B-5hsgA:
4.4		 2qx4A-5hsgA:
21.50
2qx4B-5hsgA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 GLY A 133
GLN A 271
PHE A  46
PHE A  47
 None
 0.94A 2qx6A-5hsgA:
4.3
2qx6B-5hsgA:
4.3		 2qx6A-5hsgA:
21.50
2qx6B-5hsgA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 VAL A 116
ILE A 102
ILE A  92
LEU A  93
 None
 0.67A 3hegA-5hsgA:
undetectable		 3hegA-5hsgA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 VAL A  89
ILE A  81
TYR A  84
ILE A  85
 None
 0.79A 3hgxA-5hsgA:
undetectable		 3hgxA-5hsgA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		5 / 11 ILE A 143
ALA A 223
TRP A 250
PHE A 179
LEU A 183
 None
 1.35A 4i1nA-5hsgA:
undetectable		 4i1nA-5hsgA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 ILE A 297
ILE A 117
VAL A 293
PRO A 294
 None
 0.79A 4jltA-5hsgA:
undetectable		 4jltA-5hsgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 SER A 169
GLY A 139
ASP A 135
GLY A 178
 None
 1.01A 4koeA-5hsgA:
undetectable
4koeB-5hsgA:
undetectable
4koeC-5hsgA:
3.3		 4koeA-5hsgA:
22.54
4koeB-5hsgA:
22.54
4koeC-5hsgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 SER A 169
GLY A 139
ASP A 135
GLY A 178
 None
 0.95A 4koeA-5hsgA:
undetectable
4koeB-5hsgA:
undetectable
4koeD-5hsgA:
3.6		 4koeA-5hsgA:
22.54
4koeB-5hsgA:
22.54
4koeD-5hsgA:
21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		5 / 9 GLU A 237
ILE A 245
VAL A 247
ALA A 208
ILE A 221
 None
 1.10A 4lbgB-5hsgA:
4.6		 4lbgB-5hsgA:
30.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		4 / 4 LEU A 315
SER A 311
LEU A 252
LEU A  49
 None
 1.03A 4n09A-5hsgA:
4.0		 4n09A-5hsgA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		4 / 5 LEU A 315
SER A 311
LEU A 252
LEU A  49
 None
 1.04A 4n09B-5hsgA:
5.6		 4n09B-5hsgA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		4 / 5 LEU A 315
SER A 311
LEU A 252
LEU A  49
 None
 1.03A 4n09D-5hsgA:
5.5		 4n09D-5hsgA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		6 / 12 LEU A  93
ALA A 118
ALA A 109
ILE A  81
LYS A 107
ILE A 114
 None
 1.30A 4o2bB-5hsgA:
3.9		 4o2bB-5hsgA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 GLY A 231
GLN A 201
ALA A 232
TYR A 264
GLU A 237
 None
 1.36A 4pb1A-5hsgA:
undetectable		 4pb1A-5hsgA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 GLY A 139
ASP A 135
GLY A 178
SER A 169
 None
 0.97A 4z53A-5hsgA:
3.4
4z53B-5hsgA:
2.3		 4z53A-5hsgA:
17.10
4z53B-5hsgA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		3 / 3 GLU A 226
TRP A 250
ASN A 199
 None
 1.08A 5dv4A-5hsgA:
undetectable		 5dv4A-5hsgA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		4 / 5 ILE A 245
GLN A 242
ARG A 241
GLU A 237
 None
 1.36A 5fseC-5hsgA:
2.2		 5fseC-5hsgA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 ASN A  69
VAL A  38
LEU A  93
GLN A  77
 None
 1.30A 5xdhA-5hsgA:
undetectable
5xdhC-5hsgA:
undetectable		 5xdhA-5hsgA:
16.90
5xdhC-5hsgA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 GLN A  77
ASN A  69
VAL A  38
LEU A  93
 None
 1.32A 5xdhA-5hsgA:
undetectable
5xdhC-5hsgA:
undetectable		 5xdhA-5hsgA:
16.90
5xdhC-5hsgA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 GLY A 157
GLN A 152
PHE A 147
TYR A 146
 None
 1.03A 6eqpA-5hsgA:
undetectable		 6eqpA-5hsgA:
18.23