SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hsi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 6 VAL A 546
VAL A 495
ILE A 582
ASN A 525
 None
 0.80A 1e06A-5hsiA:
undetectable		 1e06A-5hsiA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 6 ASN A 459
ALA A 337
GLY A 464
TYR A 463
 None
 0.99A 1gfzA-5hsiA:
2.5		 1gfzA-5hsiA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 TYR A 334
ILE A 403
ALA A 337
GLY A 138
HIS A 453
 None
 0.79A 1kiaA-5hsiA:
2.2		 1kiaA-5hsiA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 TYR A 334
ILE A 403
ALA A 337
GLY A 138
HIS A 453
 None
 0.78A 1kiaB-5hsiA:
undetectable		 1kiaB-5hsiA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 TYR A 334
ILE A 403
ALA A 337
GLY A 138
HIS A 453
 None
 0.78A 1kiaC-5hsiA:
undetectable		 1kiaC-5hsiA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 TYR A 334
ILE A 403
ALA A 337
GLY A 138
HIS A 453
 None
 0.84A 1nbhB-5hsiA:
undetectable		 1nbhB-5hsiA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY A 402
ALA A 161
SER A 385
ASP A 389
ILE A 388
 None
 1.13A 1nt2A-5hsiA:
undetectable		 1nt2A-5hsiA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 ILE A 306
GLY A 305
VAL A 373
PHE A 380
ALA A 302
 None
 1.13A 1nv8A-5hsiA:
undetectable		 1nv8A-5hsiA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		6 / 12 ILE A 306
GLY A 305
ILE A 271
VAL A 373
PHE A 380
ALA A 302
 None
 1.29A 1nv8B-5hsiA:
3.1		 1nv8B-5hsiA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		6 / 12 ILE A 306
GLY A 305
ILE A 271
VAL A 373
PHE A 380
ALA A 302
 None
 1.26A 1vq1B-5hsiA:
undetectable		 1vq1B-5hsiA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		6 / 12 ALA A 446
GLY A 152
GLY A 138
ILE A 154
ASP A 407
ILE A 405
 None
 1.38A 1x1aA-5hsiA:
undetectable		 1x1aA-5hsiA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 8 TYR A 147
TYR A 324
HIS A 326
GLY A 165
 None
 1.13A 2ha4A-5hsiA:
3.9		 2ha4A-5hsiA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 7 TYR A 147
TYR A 324
HIS A 326
GLY A 165
 None
 1.12A 2ha4B-5hsiA:
undetectable		 2ha4B-5hsiA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 5 SER A 127
GLY A 119
HIS A 153
ASP A 157
 None
 1.02A 2oxtB-5hsiA:
undetectable		 2oxtB-5hsiA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 11 GLU A 438
ILE A 403
GLY A 402
GLY A 401
LEU A 437
 None
 0.98A 2qmmA-5hsiA:
2.5
2qmmB-5hsiA:
2.9		 2qmmA-5hsiA:
14.22
2qmmB-5hsiA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 TYR A 334
ILE A 388
ALA A 451
SER A 448
TYR A 463
 None
 1.48A 3apwA-5hsiA:
undetectable		 3apwA-5hsiA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 5 ASN A 459
ALA A 337
GLY A 464
TYR A 463
 None
 1.01A 3bcrA-5hsiA:
3.5		 3bcrA-5hsiA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 11 GLY A 333
ALA A 329
ASP A 328
GLY A 402
ILE A 386
 None
 0.96A 3ekxA-5hsiA:
undetectable		 3ekxA-5hsiA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		3 / 3 TYR A 435
TYR A 168
ILE A 405
 None
 0.78A 3eteA-5hsiA:
undetectable
3eteB-5hsiA:
2.2		 3eteA-5hsiA:
21.79
3eteB-5hsiA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 VAL A 137
GLU A 134
HIS A 453
THR A 103
GLY A 401
 None
 1.18A 3j6pB-5hsiA:
undetectable		 3j6pB-5hsiA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		6 / 12 GLU A 164
LYS A 441
GLY A 402
SER A 385
ASP A 328
ALA A 330
 None
 1.47A 3nmuA-5hsiA:
2.0
3nmuF-5hsiA:
undetectable		 3nmuA-5hsiA:
22.03
3nmuF-5hsiA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 8 VAL A 488
VAL A 495
ILE A 609
GLN A 610
 None
 0.90A 3remA-5hsiA:
undetectable		 3remA-5hsiA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 8 VAL A 488
VAL A 495
ILE A 609
GLN A 610
 None
 0.87A 3remB-5hsiA:
undetectable		 3remB-5hsiA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		3 / 3 ARG A 230
PHE A 177
PRO A 176
 None
 0.87A 3zoaB-5hsiA:
undetectable		 3zoaB-5hsiA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 5 ASN A 112
LEU A 109
SER A 448
LEU A 104
 None
 1.31A 4n09C-5hsiA:
undetectable		 4n09C-5hsiA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY A 401
GLY A 158
ILE A 388
SER A 399
ALA A 400
 None
 1.17A 4qtuD-5hsiA:
undetectable		 4qtuD-5hsiA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY A 402
GLY A 401
ILE A 414
SER A 415
TYR A 435
 None
 0.92A 4rtmA-5hsiA:
undetectable		 4rtmA-5hsiA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 6 LEU A 104
LEU A 466
GLU A 467
TYR A 463
 None
 0.88A 4w5nA-5hsiA:
undetectable		 4w5nA-5hsiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 7 ASN A 504
TYR A 508
LEU A 498
PHE A 563
 None
 0.98A 4yv5B-5hsiA:
undetectable		 4yv5B-5hsiA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 6 LEU A 289
SER A 174
PRO A 176
PHE A 177
 None
 1.28A 5b8iA-5hsiA:
undetectable		 5b8iA-5hsiA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 6 LYS A 606
ASP A 612
TYR A 508
LEU A 481
 None
 1.35A 5bmvB-5hsiA:
undetectable		 5bmvB-5hsiA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 8 LEU A 231
LEU A 175
THR A 200
GLN A 317
 None
 1.14A 5hbsA-5hsiA:
undetectable		 5hbsA-5hsiA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 TYR A 331
ILE A 582
THR A 549
PHE A 551
LEU A 481
 None
 1.25A 5l8oB-5hsiA:
undetectable		 5l8oB-5hsiA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 7 GLY A 468
ALA A 337
PHE A 362
ASN A 504
 None
 1.00A 5mvsA-5hsiA:
undetectable		 5mvsA-5hsiA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 VAL A 137
GLU A 134
HIS A 453
THR A 103
GLY A 401
 None
 1.22A 5ogcB-5hsiA:
undetectable		 5ogcB-5hsiA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 6 GLU A 384
ARG A 313
PHE A 323
VAL A 292
 None
 1.39A 6fgdA-5hsiA:
3.9		 6fgdA-5hsiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 5hsi PUTATIVE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 11 ILE A 172
LEU A 175
PRO A 176
MET A 179
MET A 204
 None
 0.90A 6hupA-5hsiA:
undetectable
6hupB-5hsiA:
undetectable		 6hupA-5hsiA:
9.40
6hupB-5hsiA:
8.84