SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hss'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		4 / 6 HIS A 352
GLY A 354
TYR A  72
ALA A  75
 None
 0.92A 1dmaB-5hssA:
undetectable		 1dmaB-5hssA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		4 / 6 PHE A 355
ALA A  75
GLY A  73
TYR A  72
 None
 1.09A 1gfzA-5hssA:
undetectable		 1gfzA-5hssA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		5 / 11 LEU A 135
ALA A 242
ALA A 246
MET A 247
LEU A 185
 None
 1.16A 1hbpA-5hssA:
undetectable		 1hbpA-5hssA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		4 / 5 SER A 237
THR A 240
GLU A 281
GLY A 293
 None
 1.26A 1icrA-5hssA:
undetectable
1icrB-5hssA:
undetectable		 1icrA-5hssA:
18.64
1icrB-5hssA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		4 / 5 GLU A 281
GLY A 293
SER A 237
THR A 240
 None
 1.30A 1icrA-5hssA:
undetectable
1icrB-5hssA:
undetectable		 1icrA-5hssA:
18.64
1icrB-5hssA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		4 / 5 SER A 237
THR A 240
GLU A 281
GLY A 293
 None
 1.27A 1icvC-5hssA:
undetectable
1icvD-5hssA:
undetectable		 1icvC-5hssA:
18.64
1icvD-5hssA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		5 / 11 LEU A 135
ALA A 242
ALA A 246
MET A 247
LEU A 185
 None
 1.19A 1iiuA-5hssA:
undetectable		 1iiuA-5hssA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		5 / 12 PHE A  69
ALA A 246
LEU A 135
MET A 247
LEU A 185
 None
 1.24A 1qabF-5hssA:
undetectable		 1qabF-5hssA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		4 / 4 LYS A 350
LEU A 346
ALA A 349
LEU A 345
 None
 1.45A 2roxA-5hssA:
undetectable		 2roxA-5hssA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		4 / 5 PHE A 255
SER A 186
PHE A 221
ILE A 156
 None
 1.34A 2v0mD-5hssA:
undetectable		 2v0mD-5hssA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		5 / 7 MET A  34
PHE A  43
ALA A  95
ALA A  71
LEU A 348
 None
 1.41A 2wx2A-5hssA:
undetectable		 2wx2A-5hssA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		4 / 8 THR A 140
GLN A 137
SER A 142
TYR A 133
 None
 1.14A 2xz5A-5hssA:
undetectable
2xz5C-5hssA:
undetectable		 2xz5A-5hssA:
20.00
2xz5C-5hssA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		4 / 8 THR A 140
GLN A 137
SER A 142
TYR A 133
 None
 1.17A 2xz5C-5hssA:
undetectable
2xz5D-5hssA:
undetectable		 2xz5C-5hssA:
20.00
2xz5D-5hssA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		5 / 12 THR A 202
ILE A 209
LEU A 206
THR A 240
LEU A 245
 None
 1.16A 3a51C-5hssA:
undetectable		 3a51C-5hssA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		5 / 12 LEU A 152
ILE A 123
ALA A 183
SER A 186
LEU A 187
 None
 0.99A 3n8zB-5hssA:
undetectable		 3n8zB-5hssA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		4 / 4 PRO A 364
LEU A 138
HIS A 149
LEU A 152
 None
 1.39A 3vw7A-5hssA:
undetectable		 3vw7A-5hssA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		5 / 11 TYR A 225
LEU A 187
ILE A 123
ILE A 160
PHE A 208
 None
 1.43A 4a7aA-5hssA:
undetectable		 4a7aA-5hssA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		4 / 5 HIS A 249
LEU A 311
LEU A 300
ASP A 313
 None
 1.28A 4aqlA-5hssA:
undetectable		 4aqlA-5hssA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		4 / 8 SER A  66
ILE A  67
TRP A  53
PHE A  50
 None
 1.16A 4cx7A-5hssA:
undetectable
4cx7B-5hssA:
undetectable		 4cx7A-5hssA:
18.30
4cx7B-5hssA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		4 / 8 SER A  66
ILE A  67
TRP A  53
PHE A  50
 None
 1.21A 4cx7C-5hssA:
undetectable
4cx7D-5hssA:
0.0		 4cx7C-5hssA:
18.30
4cx7D-5hssA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		5 / 9 VAL A 270
LEU A 316
SER A 296
THR A 299
LEU A 300
 None
 1.05A 4ubsA-5hssA:
undetectable		 4ubsA-5hssA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		5 / 12 GLU A 344
TRP A  53
TYR A  70
LEU A 341
THR A  58
 None
None
None
64Z  A 402 (-4.7A)
None
 1.45A 4xqeA-5hssA:
undetectable		 4xqeA-5hssA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B504_1
(HOMOSPERMIDINE
SYNTHASE)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		5 / 12 GLU A 344
TRP A  53
TYR A  70
LEU A 341
THR A  58
 None
None
None
64Z  A 402 (-4.7A)
None
 1.45A 4xqeB-5hssA:
undetectable		 4xqeB-5hssA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_A_AG2A502_1
(HOMOSPERMIDINE
SYNTHASE)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		5 / 12 GLU A 344
TRP A  53
TYR A  70
LEU A 341
THR A  58
 None
None
None
64Z  A 402 (-4.7A)
None
 1.45A 4xrgA-5hssA:
undetectable		 4xrgA-5hssA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_B_AG2B502_1
(HOMOSPERMIDINE
SYNTHASE)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		5 / 12 GLU A 344
TRP A  53
TYR A  70
LEU A 341
THR A  58
 None
None
None
64Z  A 402 (-4.7A)
None
 1.46A 4xrgB-5hssA:
undetectable		 4xrgB-5hssA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		4 / 6 ALA A  71
HIS A 128
MET A  99
LEU A 131
 None
 1.23A 5dzkB-5hssA:
undetectable
5dzkP-5hssA:
undetectable		 5dzkB-5hssA:
19.89
5dzkP-5hssA:
0.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		3 / 3 ASP A 343
SER A  66
TYR A  70
 None
 0.72A 5glmA-5hssA:
undetectable		 5glmA-5hssA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		4 / 5 PRO A 364
HIS A 194
LEU A 131
TYR A 145
 None
 1.41A 5igjA-5hssA:
undetectable		 5igjA-5hssA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		5 / 12 LEU A 294
ALA A 295
PHE A 298
THR A 299
THR A 282
 None
 0.95A 5k9dA-5hssA:
undetectable		 5k9dA-5hssA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		4 / 5 LEU A 131
LEU A 185
MET A 361
TYR A 136
 None
 1.30A 5uc3A-5hssA:
undetectable		 5uc3A-5hssA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		4 / 4 LYS A 350
LEU A 346
ALA A 349
LEU A 345
 None
 1.43A 6gnrA-5hssA:
undetectable		 6gnrA-5hssA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 5hss LINALOOL
DEHYDRATASE/ISOMERAS
E
(Castellaniella
defragrans) 		4 / 4 LYS A 350
LEU A 346
ALA A 349
LEU A 345
 None
 1.42A 6gnrB-5hssA:
undetectable		 6gnrB-5hssA:
17.53