SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hst'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 5hst POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		5 / 11 GLU A 157
ILE A 153
GLY A 218
THR A 217
GLY A 222
 None
 1.17A 1i7qA-5hstA:
undetectable		 1i7qA-5hstA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)		 5hst POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		5 / 10 GLU A 157
ILE A 153
GLY A 218
THR A 217
GLY A 222
 None
 1.17A 1i7qC-5hstA:
undetectable		 1i7qC-5hstA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 5hst POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		4 / 6 PRO A 206
HIS A  46
ASP A  45
TYR A  41
 None
 1.14A 2lh8A-5hstA:
undetectable		 2lh8A-5hstA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 5hst POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		4 / 6 LEU A 279
PHE A 270
ILE A 212
PHE A 219
 None
 0.96A 3ko0S-5hstA:
undetectable		 3ko0S-5hstA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5hst POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		5 / 8 SER A 165
ARG A 290
ALA A 288
LEU A 289
PHE A 108
 None
 1.24A 4rkuA-5hstA:
undetectable
4rkuJ-5hstA:
undetectable		 4rkuA-5hstA:
17.24
4rkuJ-5hstA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5hst POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		4 / 5 ILE A 181
VAL A 186
PHE A 213
CYH A 158
 None
 1.32A 4rzvA-5hstA:
undetectable		 4rzvA-5hstA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5hst POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		5 / 9 SER A 165
ARG A 290
ALA A 288
LEU A 289
PHE A 108
 None
 1.18A 4y28A-5hstA:
undetectable
4y28J-5hstA:
undetectable		 4y28A-5hstA:
16.80
4y28J-5hstA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 5hst POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		5 / 12 GLY A 222
LEU A 284
PHE A 213
ILE A  59
GLY A  56
 None
 1.18A 5fsaB-5hstA:
undetectable		 5fsaB-5hstA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 5hst POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		5 / 11 ILE A  59
ILE A  97
THR A 112
VAL A  53
LEU A  36
 None
 1.13A 5jkwA-5hstA:
undetectable		 5jkwA-5hstA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5hst POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		5 / 12 ALA A 229
VAL A  48
ASP A 210
GLY A  56
LEU A 284
 None
 1.11A 5x24A-5hstA:
undetectable		 5x24A-5hstA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 5hst POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		6 / 12 ALA A 229
VAL A  48
ASP A 210
GLY A  56
ALA A  57
LEU A 284
 None
 1.21A 5xxiA-5hstA:
undetectable		 5xxiA-5hstA:
19.36