SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hsx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5hsx PUTATIVE
ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 12 ILE A 129
ALA A 127
ILE A  42
PHE A  71
LEU A 285
 None
 0.96A 2aclG-5hsxA:
undetectable		 2aclG-5hsxA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5hsx PUTATIVE
ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Paraburkholderia
xenovorans) 		3 / 3 PHE A  71
PHE A 257
PHE A  54
 None
 0.82A 2od9A-5hsxA:
undetectable		 2od9A-5hsxA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5hsx PUTATIVE
ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 12 ILE A  93
VAL A  51
THR A 284
ASP A 117
HIS A  64
 EDO  A 409 (-4.6A)
None
None
NA  A 401 (-3.6A)
None
 1.41A 2qo4A-5hsxA:
undetectable		 2qo4A-5hsxA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5hsx PUTATIVE
ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Paraburkholderia
xenovorans) 		3 / 3 PHE A  71
PHE A 257
PHE A  54
 None
 0.82A 2qqgA-5hsxA:
undetectable		 2qqgA-5hsxA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5hsx PUTATIVE
ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 12 ILE A 129
ALA A 127
ILE A  42
PHE A  71
LEU A 285
 None
 0.78A 3dzuA-5hsxA:
undetectable		 3dzuA-5hsxA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5hsx PUTATIVE
ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Paraburkholderia
xenovorans) 		4 / 5 LEU A  59
ARG A  55
ILE A  25
PHE A  54
 None
 1.32A 3ln1D-5hsxA:
undetectable		 3ln1D-5hsxA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 5hsx PUTATIVE
ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Paraburkholderia
xenovorans) 		4 / 7 PHE A 161
SER A 228
VAL A 230
VAL A 223
 None
 1.32A 3n61A-5hsxA:
undetectable
3n61B-5hsxA:
undetectable		 3n61A-5hsxA:
21.27
3n61B-5hsxA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 5hsx PUTATIVE
ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Paraburkholderia
xenovorans) 		4 / 4 ILE A 129
VAL A  52
VAL A 255
ARG A 131
 None
 1.36A 4m6tA-5hsxA:
undetectable		 4m6tA-5hsxA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5hsx PUTATIVE
ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Paraburkholderia
xenovorans) 		3 / 3 GLU A 207
HIS A 202
ARG A 200
 None
 0.93A 5uunA-5hsxA:
undetectable		 5uunA-5hsxA:
22.57