SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hsz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 5hsz NUCLEOID OCCLUSION
FACTOR SLMA
(Klebsiella
pneumoniae) 		4 / 6 LEU A 162
PHE A 165
ALA A 164
LEU A 136
 None
 0.85A 1ukbA-5hszA:
undetectable		 1ukbA-5hszA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 5hsz NUCLEOID OCCLUSION
FACTOR SLMA
(Klebsiella
pneumoniae) 		5 / 12 GLY A  97
GLY A  99
LEU A 105
GLY A 104
ARG A 107
 None
 1.18A 1y4lA-5hszA:
undetectable		 1y4lA-5hszA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 5hsz NUCLEOID OCCLUSION
FACTOR SLMA
(Klebsiella
pneumoniae) 		4 / 6 LEU A 105
THR A 106
PHE A  98
ASP A  68
 None
 0.97A 2wm3A-5hszA:
undetectable		 2wm3A-5hszA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5hsz NUCLEOID OCCLUSION
FACTOR SLMA
(Klebsiella
pneumoniae) 		5 / 9 THR A  34
ALA A  35
LEU A  37
ALA A  39
SER A  40
 None
 1.36A 3kp6B-5hszA:
1.2		 3kp6B-5hszA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB511_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5hsz NUCLEOID OCCLUSION
FACTOR SLMA
(Klebsiella
pneumoniae) 		4 / 5 SER A  61
GLU A  13
LEU A  16
GLN A  17
 None
 1.41A 3pgyB-5hszA:
undetectable		 3pgyB-5hszA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5hsz NUCLEOID OCCLUSION
FACTOR SLMA
(Klebsiella
pneumoniae) 		3 / 3 ARG A 137
MET A 140
ARG A 141
 None
 1.24A 3uvvA-5hszA:
undetectable		 3uvvA-5hszA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5hsz NUCLEOID OCCLUSION
FACTOR SLMA
(Klebsiella
pneumoniae) 		5 / 12 ILE A  66
ILE A 108
LEU A 105
ASP A  60
LEU A 121
 None
 1.21A 5km9B-5hszA:
undetectable		 5km9B-5hszA:
21.81