SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ht0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		5 / 12 LEU A  60
GLU A 124
LEU A  20
GLY A  23
PHE A 128
 None
 1.44A 1d4fA-5ht0A:
undetectable		 1d4fA-5ht0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		5 / 12 LEU A  60
GLU A 124
LEU A  20
GLY A  23
PHE A 128
 None
 1.44A 1d4fB-5ht0A:
undetectable		 1d4fB-5ht0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		5 / 12 LEU A  60
GLU A 124
LEU A  20
GLY A  23
PHE A 128
 None
 1.44A 1d4fC-5ht0A:
undetectable		 1d4fC-5ht0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		5 / 12 LEU A  60
GLU A 124
LEU A  20
GLY A  23
PHE A 128
 None
 1.40A 1d4fD-5ht0A:
undetectable		 1d4fD-5ht0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		5 / 10 GLY A  36
VAL A  35
LEU A  11
SER A   6
ALA A 237
 None
 0.86A 1pbcA-5ht0A:
undetectable		 1pbcA-5ht0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA888_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		4 / 5 PRO A 143
LYS A 146
ALA A 150
GLU A 124
 None
 1.18A 1qhsA-5ht0A:
undetectable		 1qhsA-5ht0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		5 / 12 LEU A  20
ALA A  25
GLY A 123
GLY A 122
ILE A 121
 None
 1.09A 2o4kA-5ht0A:
undetectable		 2o4kA-5ht0A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		4 / 5 ARG A 110
ALA A  63
ASP A  64
TRP A  65
 None
 1.17A 2xrzA-5ht0A:
undetectable		 2xrzA-5ht0A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y4N_B_PACB503_0
(PHENYLACETATE-COENZY
ME A LIGASE)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		4 / 4 SER A 111
GLY A 139
GLY A 145
LYS A 146
 None
 1.03A 2y4nB-5ht0A:
undetectable		 2y4nB-5ht0A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		4 / 8 HIS A 168
SER A 205
ASP A  69
LEU A  67
 None
 1.04A 3n2oC-5ht0A:
undetectable
3n2oD-5ht0A:
undetectable		 3n2oC-5ht0A:
17.16
3n2oD-5ht0A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		3 / 3 TYR A 138
TYR A  62
GLU A 171
 None
COA  A 301 (-4.7A)
None
 0.83A 3pfgA-5ht0A:
undetectable		 3pfgA-5ht0A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		4 / 5 HIS A 169
GLY A 139
TYR A 138
GLU A 171
 None
 1.45A 4ae1B-5ht0A:
undetectable		 4ae1B-5ht0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		5 / 12 LEU A  46
ILE A 102
ALA A 120
ALA A  25
GLY A 152
 None
 1.05A 4enhA-5ht0A:
undetectable		 4enhA-5ht0A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		4 / 7 ILE A 121
LEU A  46
ASP A  43
ASP A  47
 None
 1.02A 4mmcA-5ht0A:
undetectable		 4mmcA-5ht0A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		3 / 3 GLU A 124
ALA A 125
PHE A 128
 None
 0.59A 4v1fA-5ht0A:
undetectable		 4v1fA-5ht0A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		3 / 3 GLU A 124
ALA A 125
PHE A 128
 None
 0.63A 4v1fC-5ht0A:
undetectable		 4v1fC-5ht0A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		5 / 11 ILE A 234
SER A 239
GLY A 232
ASP A  14
GLU A 236
 None
 1.23A 4xt7A-5ht0A:
1.9		 4xt7A-5ht0A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		5 / 12 ILE A 234
SER A 239
GLY A 232
ASP A  14
GLU A 236
 None
 1.22A 4xt8A-5ht0A:
undetectable		 4xt8A-5ht0A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		5 / 11 ASN A  95
TYR A 138
HIS A 168
THR A 204
ASP A 206
 COA  A 301 (-3.9A)
None
None
None
None
 1.13A 6mb5A-5ht0A:
39.4		 6mb5A-5ht0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		8 / 11 TYR A  62
ASP A  64
TYR A 138
ASP A 162
THR A 163
HIS A 168
THR A 204
ASP A 206
 COA  A 301 (-4.7A)
None
None
None
COA  A 301 (-3.9A)
None
None
None
 0.60A 6mb5A-5ht0A:
39.4		 6mb5A-5ht0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB7_A_PARA900_0
(AAC(3)-IIIB PROTEIN)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		7 / 10 TYR A  62
ASP A  64
TYR A 138
THR A 163
HIS A 168
THR A 204
ASP A 206
 COA  A 301 (-4.7A)
None
None
COA  A 301 (-3.9A)
None
None
None
 0.54A 6mb7A-5ht0A:
39.3		 6mb7A-5ht0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_A_NMYA303_0
(AAC(3)-IIIB PROTEIN)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		8 / 10 TYR A  62
ASP A  64
TYR A 138
ASP A 162
THR A 163
HIS A 168
THR A 204
ASP A 206
 COA  A 301 (-4.7A)
None
None
None
COA  A 301 (-3.9A)
None
None
None
 0.58A 6mb9A-5ht0A:
39.8		 6mb9A-5ht0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_B_NMYB302_0
(AAC(3)-IIIB PROTEIN)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		8 / 10 TYR A  62
ASP A  64
TYR A 138
ASP A 162
THR A 163
HIS A 168
THR A 204
ASP A 206
 COA  A 301 (-4.7A)
None
None
None
COA  A 301 (-3.9A)
None
None
None
 0.53A 6mb9B-5ht0A:
39.8		 6mb9B-5ht0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		8 / 10 TYR A  62
ASP A  64
TYR A 138
ASP A 162
THR A 163
HIS A 168
THR A 204
ASP A 206
 COA  A 301 (-4.7A)
None
None
None
COA  A 301 (-3.9A)
None
None
None
 0.56A 6mb9C-5ht0A:
39.6		 6mb9C-5ht0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		8 / 10 TYR A  62
ASP A  64
TYR A 138
ASP A 162
THR A 163
HIS A 168
THR A 204
ASP A 206
 COA  A 301 (-4.7A)
None
None
None
COA  A 301 (-3.9A)
None
None
None
 0.58A 6mb9D-5ht0A:
39.6		 6mb9D-5ht0A:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MN1_A_LLLA302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		6 / 10 ASP A  64
TRP A  65
GLY A 115
TYR A 138
ASP A 213
THR A 204
 None
 1.47A 6mn1A-5ht0A:
43.8		 6mn1A-5ht0A:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MN1_A_LLLA302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		8 / 10 TRP A  65
ASP A  69
GLY A 115
TYR A 138
ASP A 162
THR A 163
THR A 204
SER A 205
 None
None
None
None
None
COA  A 301 (-3.9A)
None
None
 0.76A 6mn1A-5ht0A:
43.8		 6mn1A-5ht0A:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MN1_A_LLLA302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		9 / 10 TYR A  62
ASP A  64
TRP A  65
ASP A  69
GLY A 115
TYR A 138
ASP A 162
THR A 163
THR A 204
 COA  A 301 (-4.7A)
None
None
None
None
None
None
COA  A 301 (-3.9A)
None
 0.53A 6mn1A-5ht0A:
43.8		 6mn1A-5ht0A:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MN1_B_LLLB302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		5 / 10 ASP A  64
TRP A  65
GLY A 115
TYR A 138
ASP A 213
 None
 1.26A 6mn1B-5ht0A:
43.8		 6mn1B-5ht0A:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MN1_B_LLLB302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005
(uncultured
bacterium) 		10 / 10 TYR A  62
ASP A  64
TRP A  65
ASP A  69
GLY A 115
TYR A 138
ASP A 162
THR A 163
THR A 204
SER A 205
 COA  A 301 (-4.7A)
None
None
None
None
None
None
COA  A 301 (-3.9A)
None
None
 0.68A 6mn1B-5ht0A:
43.8		 6mn1B-5ht0A:
98.75