SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ht6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_A_SORA1341_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	5ht6	HISTONE-LYSINE N-METHYLTRANSFERASE 2E (Homo sapiens)	4 / 7	ARG A 106 ARG A 95 ASP A 93 TYR A 55	None	1.41A	5a06A-5ht6A: undetectable	5a06A-5ht6A: 14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_C_SORC1341_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	5ht6	HISTONE-LYSINE N-METHYLTRANSFERASE 2E (Homo sapiens)	4 / 7	ARG A 106 ARG A 95 ASP A 93 TYR A 55	None	1.42A	5a06C-5ht6A: undetectable	5a06C-5ht6A: 14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_D_SORD1342_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	5ht6	HISTONE-LYSINE N-METHYLTRANSFERASE 2E (Homo sapiens)	4 / 7	ARG A 106 ARG A 95 ASP A 93 TYR A 55	None	1.41A	5a06D-5ht6A: undetectable	5a06D-5ht6A: 14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_E_SORE1342_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	5ht6	HISTONE-LYSINE N-METHYLTRANSFERASE 2E (Homo sapiens)	4 / 7	ARG A 106 ARG A 95 ASP A 93 TYR A 55	None	1.41A	5a06E-5ht6A: undetectable	5a06E-5ht6A: 14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_F_SORF1343_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	5ht6	HISTONE-LYSINE N-METHYLTRANSFERASE 2E (Homo sapiens)	4 / 7	ARG A 106 ARG A 95 ASP A 93 TYR A 55	None	1.43A	5a06F-5ht6A: undetectable	5a06F-5ht6A: 14.63

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["5A06_A_SORA1341_0","ALDOSE-ALDOSE OXIDOREDUCTASE","5ht6","HISTONE-LYSINE N-METHYLTRANSFERASE 2E","Homo sapiens",4,"ARG A 106;ARG A  95;ASP A  93;TYR A  55","None","1.41A","5a06A-5ht6A:undetectable","5a06A-5ht6A:14.63"],["5A06_C_SORC1341_0","ALDOSE-ALDOSE OXIDOREDUCTASE","5ht6","HISTONE-LYSINE N-METHYLTRANSFERASE 2E","Homo sapiens",4,"ARG A 106;ARG A  95;ASP A  93;TYR A  55","None","1.42A","5a06C-5ht6A:undetectable","5a06C-5ht6A:14.63"],["5A06_D_SORD1342_0","ALDOSE-ALDOSE OXIDOREDUCTASE","5ht6","HISTONE-LYSINE N-METHYLTRANSFERASE 2E","Homo sapiens",4,"ARG A 106;ARG A  95;ASP A  93;TYR A  55","None","1.41A","5a06D-5ht6A:undetectable","5a06D-5ht6A:14.63"],["5A06_E_SORE1342_0","ALDOSE-ALDOSE OXIDOREDUCTASE","5ht6","HISTONE-LYSINE N-METHYLTRANSFERASE 2E","Homo sapiens",4,"ARG A 106;ARG A  95;ASP A  93;TYR A  55","None","1.41A","5a06E-5ht6A:undetectable","5a06E-5ht6A:14.63"],["5A06_F_SORF1343_0","ALDOSE-ALDOSE OXIDOREDUCTASE","5ht6","HISTONE-LYSINE N-METHYLTRANSFERASE 2E","Homo sapiens",4,"ARG A 106;ARG A  95;ASP A  93;TYR A  55","None","1.43A","5a06F-5ht6A:undetectable","5a06F-5ht6A:14.63"]]