SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5htk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RXC_C_URFC2081_1 (URIDINE PHOSPHORYLASE)	5htk	6-PHOSPHOFRUCTO-2-KI NASE/FRUCTOSE-2,6-BI SPHOSPHATASE 2 (Homo sapiens)	4 / 7	GLY A 222 GLN A 248 ILE A 219 VAL A 218	GOL A 607 (-3.3A) GOL A 607 ( 4.1A) None None	0.99A	1rxcC-5htkA: undetectable	1rxcC-5htkA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RXC_D_URFD2021_1 (URIDINE PHOSPHORYLASE)	5htk	6-PHOSPHOFRUCTO-2-KI NASE/FRUCTOSE-2,6-BI SPHOSPHATASE 2 (Homo sapiens)	4 / 7	GLY A 222 GLN A 248 ILE A 219 VAL A 218	GOL A 607 (-3.3A) GOL A 607 ( 4.1A) None None	1.02A	1rxcD-5htkA: undetectable	1rxcD-5htkA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WSV_A_THHA3001_0 (AMINOMETHYLTRANSFERA SE)	5htk	6-PHOSPHOFRUCTO-2-KI NASE/FRUCTOSE-2,6-BI SPHOSPHATASE 2 (Homo sapiens)	5 / 12	THR A 424 LEU A 423 ILE A 252 VAL A 386 LEU A 399	None	1.31A	1wsvA-5htkA: undetectable	1wsvA-5htkA: 21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2AXN_A_EDTA737_0 (6-PHOSPHOFRUCTO-2-KI NASE/FRUCTOSE-2,6-BI PHOSPHATASE 3 (6PF-2-K/FRU- 2,6-P2ASE BRAIN/PLACENTA-TYPE ISOZYME) (IPFK-2) [INCLUDES: 6- PHOSPHOFRUCTO-2-KINA SE (EC 2.7.1.105) FRUCTOSE-2,6-BISPHO SPHATASE (EC 3.1.3.46)])	5htk	6-PHOSPHOFRUCTO-2-KI NASE/FRUCTOSE-2,6-BI SPHOSPHATASE 2 (Homo sapiens)	12 / 12	PRO A 47 LYS A 51 THR A 52 ASN A 73 GLY A 75 ARG A 79 PHE A 91 ARG A 102 ALA A 129 THR A 130 ARG A 193 TYR A 197	ATP A 602 (-4.3A) ATP A 602 (-2.7A) ATP A 602 ( 3.1A) ATP A 602 ( 3.9A) FLC A 601 (-3.0A) ATP A 602 ( 4.1A) FLC A 601 ( 4.8A) GOL A 606 ( 2.0A) FLC A 601 (-3.3A) FLC A 601 (-2.7A) None GOL A 606 ( 3.4A)	0.54A	2axnA-5htkA: 48.1	2axnA-5htkA: 67.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5htk	6-PHOSPHOFRUCTO-2-KI NASE/FRUCTOSE-2,6-BI SPHOSPHATASE 2 (Homo sapiens)	4 / 7	TYR A 337 TYR A 412 TYR A 360 ILE A 327	F6P A 604 (-4.6A) None None F6P A 604 ( 4.4A)	1.13A	2ph9A-5htkA: undetectable 2ph9B-5htkA: undetectable	2ph9A-5htkA: 19.04 2ph9B-5htkA: 19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_B_CHDB153_0 (ILEAL BILE ACID-BINDING PROTEIN)	5htk	6-PHOSPHOFRUCTO-2-KI NASE/FRUCTOSE-2,6-BI SPHOSPHATASE 2 (Homo sapiens)	4 / 6	THR A 59 LYS A 56 PHE A 72 TYR A 116	None	1.16A	3elzB-5htkA: undetectable	3elzB-5htkA: 15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GWX_B_EPAB3_2 (PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR-DELTA)))	5htk	6-PHOSPHOFRUCTO-2-KI NASE/FRUCTOSE-2,6-BI SPHOSPHATASE 2 (Homo sapiens)	5 / 12	LEU A 213 ARG A 137 LEU A 40 VAL A 42 VAL A 151	None	1.10A	3gwxB-5htkA: undetectable	3gwxB-5htkA: 19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PGY_A_GLYA510_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5htk	6-PHOSPHOFRUCTO-2-KI NASE/FRUCTOSE-2,6-BI SPHOSPHATASE 2 (Homo sapiens)	4 / 6	GLU A 364 ILE A 327 GLU A 326 ASN A 325	None F6P A 604 ( 4.4A) F6P A 604 (-3.1A) None	1.01A	3pgyA-5htkA: undetectable 3pgyB-5htkA: undetectable	3pgyA-5htkA: 22.20 3pgyB-5htkA: 22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z7F_C_FOLC201_0 (FOLATE ECF TRANSPORTER)	5htk	6-PHOSPHOFRUCTO-2-KI NASE/FRUCTOSE-2,6-BI SPHOSPHATASE 2 (Homo sapiens)	5 / 12	SER A 272 ALA A 329 THR A 336 THR A 444 ARG A 256	None F6P A 604 ( 4.9A) None F6P A 604 ( 3.3A) NEP A 257 ( 3.7A)	1.26A	4z7fC-5htkA: undetectable	4z7fC-5htkA: 19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_B_SORB1341_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	5htk	6-PHOSPHOFRUCTO-2-KI NASE/FRUCTOSE-2,6-BI SPHOSPHATASE 2 (Homo sapiens)	4 / 7	ARG A 136 PHE A 90 ARG A 78 ILE A 101	None None FLC A 601 (-3.9A) None	1.40A	5a06B-5htkA: undetectable	5a06B-5htkA: 20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IWU_A_ERYA404_1 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	5htk	6-PHOSPHOFRUCTO-2-KI NASE/FRUCTOSE-2,6-BI SPHOSPHATASE 2 (Homo sapiens)	4 / 6	GLY A 75 ASP A 189 ILE A 194 TYR A 197	FLC A 601 (-3.0A) None None GOL A 606 ( 3.4A)	0.84A	5iwuA-5htkA: undetectable	5iwuA-5htkA: 19.52

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RXC_C_URFC2081_1","URIDINE PHOSPHORYLASE","5htk","6-PHOSPHOFRUCTO-2-KINASE\/FRUCTOSE-2,6-BISPHOSPHATASE 2","Homo sapiens",4,"GLY A 222;GLN A 248;ILE A 219;VAL A 218","GOL A 607 (-3.3A);GOL A 607 ( 4.1A);None;None","0.99A","1rxcC-5htkA:undetectable","1rxcC-5htkA:20.00"],["1RXC_D_URFD2021_1","URIDINE PHOSPHORYLASE","5htk","6-PHOSPHOFRUCTO-2-KINASE\/FRUCTOSE-2,6-BISPHOSPHATASE 2","Homo sapiens",4,"GLY A 222;GLN A 248;ILE A 219;VAL A 218","GOL A 607 (-3.3A);GOL A 607 ( 4.1A);None;None","1.02A","1rxcD-5htkA:undetectable","1rxcD-5htkA:20.00"],["1WSV_A_THHA3001_0","AMINOMETHYLTRANSFERASE","5htk","6-PHOSPHOFRUCTO-2-KINASE\/FRUCTOSE-2,6-BISPHOSPHATASE 2","Homo sapiens",5,"THR A 424;LEU A 423;ILE A 252;VAL A 386;LEU A 399","None","1.31A","1wsvA-5htkA:undetectable","1wsvA-5htkA:21.50"],["2AXN_A_EDTA737_0","6-PHOSPHOFRUCTO-2-KINASE\/FRUCTOSE-2,6-BIPHOSPHATASE 3 (6PF-2-K\/FRU- 2,6-P2ASE BRAIN\/PLACENTA-TYPE ISOZYME) (IPFK-2) [INCLUDES: 6- PHOSPHOFRUCTO-2-KINASE (EC 2.7.1.105); FRUCTOSE-2,6-BISPHOSPHATASE (EC 3.1.3.46)]","5htk","6-PHOSPHOFRUCTO-2-KINASE\/FRUCTOSE-2,6-BISPHOSPHATASE 2","Homo sapiens",12,"PRO A  47;LYS A  51;THR A  52;ASN A  73;GLY A  75;ARG A  79;PHE A  91;ARG A 102;ALA A 129;THR A 130;ARG A 193;TYR A 197","ATP A 602 (-4.3A);ATP A 602 (-2.7A);ATP A 602 ( 3.1A);ATP A 602 ( 3.9A);FLC A 601 (-3.0A);ATP A 602 ( 4.1A);FLC A 601 ( 4.8A);GOL A 606 ( 2.0A);FLC A 601 (-3.3A);FLC A 601 (-2.7A);None;GOL A 606 ( 3.4A)","0.54A","2axnA-5htkA:48.1","2axnA-5htkA:67.43"],["2PH9_A_GNTA301_1","SOLUBLE ACETYLCHOLINE RECEPTOR;SOLUBLE ACETYLCHOLINE RECEPTOR","5htk","6-PHOSPHOFRUCTO-2-KINASE\/FRUCTOSE-2,6-BISPHOSPHATASE 2","Homo sapiens",4,"TYR A 337;TYR A 412;TYR A 360;ILE A 327","F6P A 604 (-4.6A);None;None;F6P A 604 ( 4.4A)","1.13A","2ph9A-5htkA:undetectable;2ph9B-5htkA:undetectable","2ph9A-5htkA:19.04;2ph9B-5htkA:19.04"],["3ELZ_B_CHDB153_0","ILEAL BILE ACID-BINDING PROTEIN","5htk","6-PHOSPHOFRUCTO-2-KINASE\/FRUCTOSE-2,6-BISPHOSPHATASE 2","Homo sapiens",4,"THR A  59;LYS A  56;PHE A  72;TYR A 116","None","1.16A","3elzB-5htkA:undetectable","3elzB-5htkA:15.43"],["3GWX_B_EPAB3_2","PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR-DELTA))","5htk","6-PHOSPHOFRUCTO-2-KINASE\/FRUCTOSE-2,6-BISPHOSPHATASE 2","Homo sapiens",5,"LEU A 213;ARG A 137;LEU A  40;VAL A  42;VAL A 151","None","1.10A","3gwxB-5htkA:undetectable","3gwxB-5htkA:19.32"],["3PGY_A_GLYA510_0","SERINE HYDROXYMETHYLTRANSFERASE","5htk","6-PHOSPHOFRUCTO-2-KINASE\/FRUCTOSE-2,6-BISPHOSPHATASE 2","Homo sapiens",4,"GLU A 364;ILE A 327;GLU A 326;ASN A 325","None;F6P A 604 ( 4.4A);F6P A 604 (-3.1A);None","1.01A","3pgyA-5htkA:undetectable;3pgyB-5htkA:undetectable","3pgyA-5htkA:22.20;3pgyB-5htkA:22.20"],["4Z7F_C_FOLC201_0","FOLATE ECF TRANSPORTER","5htk","6-PHOSPHOFRUCTO-2-KINASE\/FRUCTOSE-2,6-BISPHOSPHATASE 2","Homo sapiens",5,"SER A 272;ALA A 329;THR A 336;THR A 444;ARG A 256","None;F6P A 604 ( 4.9A);None;F6P A 604 ( 3.3A);NEP A 257 ( 3.7A)","1.26A","4z7fC-5htkA:undetectable","4z7fC-5htkA:19.01"],["5A06_B_SORB1341_0","ALDOSE-ALDOSE OXIDOREDUCTASE","5htk","6-PHOSPHOFRUCTO-2-KINASE\/FRUCTOSE-2,6-BISPHOSPHATASE 2","Homo sapiens",4,"ARG A 136;PHE A  90;ARG A  78;ILE A 101","None;None;FLC A 601 (-3.9A);None","1.40A","5a06B-5htkA:undetectable","5a06B-5htkA:20.96"],["5IWU_A_ERYA404_1","MACROLIDE 2'-PHOSPHOTRANSFERASE II","5htk","6-PHOSPHOFRUCTO-2-KINASE\/FRUCTOSE-2,6-BISPHOSPHATASE 2","Homo sapiens",4,"GLY A  75;ASP A 189;ILE A 194;TYR A 197","FLC A 601 (-3.0A);None;None;GOL A 606 ( 3.4A)","0.84A","5iwuA-5htkA:undetectable","5iwuA-5htkA:19.52"]]