SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5htp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		5 / 12 LEU A 410
GLU A 191
LEU A 272
LEU A 267
GLY A 268
 None
 1.46A 1d4fA-5htpA:
undetectable		 1d4fA-5htpA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		3 / 4 VAL A  43
TRP A  49
TRP A  44
 None
 1.44A 1gmkC-5htpA:
undetectable
1gmkD-5htpA:
undetectable		 1gmkC-5htpA:
10.16
1gmkD-5htpA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		4 / 7 SER A 146
ALA A  67
SER A 156
ALA A 142
 None
 1.05A 1k5qA-5htpA:
undetectable
1k5qB-5htpA:
undetectable		 1k5qA-5htpA:
19.75
1k5qB-5htpA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		4 / 4 LEU A 284
SER A 297
LEU A 241
LEU A 349
 ANP  A 501 (-4.6A)
None
None
None
 1.16A 1yajA-5htpA:
undetectable		 1yajA-5htpA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		5 / 12 LEU A  52
ALA A  16
THR A 407
ILE A 199
LEU A 209
 None
 1.06A 2jn3A-5htpA:
undetectable		 2jn3A-5htpA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		4 / 5 LEU A 386
GLN A 351
THR A 350
THR A 303
 None
 1.29A 2zj0C-5htpA:
undetectable		 2zj0C-5htpA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		4 / 6 TYR A  91
GLY A  13
THR A  71
GLU A  46
 None
 1.02A 3fpjA-5htpA:
undetectable		 3fpjA-5htpA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		5 / 12 LEU A 410
THR A 220
LEU A 272
LEU A 267
GLY A 268
 None
 1.38A 3g1uB-5htpA:
undetectable		 3g1uB-5htpA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		5 / 12 VAL A 255
SER A 251
THR A 354
GLY A 275
LEU A 247
 None
 1.02A 3j6pB-5htpA:
undetectable		 3j6pB-5htpA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		5 / 11 ILE A 223
ALA A 142
ALA A  67
ALA A 224
THR A 407
 None
 1.11A 3mdtB-5htpA:
undetectable		 3mdtB-5htpA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		4 / 5 GLU A 236
GLY A 235
TYR A 357
GLN A 361
 None
 1.35A 3w9tD-5htpA:
undetectable		 3w9tD-5htpA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		4 / 5 GLU A 236
GLY A 235
TYR A 357
GLN A 361
 None
 1.30A 3w9tE-5htpA:
undetectable		 3w9tE-5htpA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		4 / 5 GLU A 236
GLY A 235
TYR A 357
GLN A 361
 None
 1.35A 3w9tG-5htpA:
undetectable		 3w9tG-5htpA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		5 / 12 ILE A  66
ALA A  67
THR A 407
GLY A  10
ALA A  16
 None
 1.12A 4enhA-5htpA:
undetectable		 4enhA-5htpA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		5 / 12 LEU A 345
LEU A 342
LEU A 296
ARG A 334
THR A 291
 None
 1.18A 4f4dA-5htpA:
undetectable		 4f4dA-5htpA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		3 / 3 HIS A 265
TRP A 271
SER A  72
 None
 1.09A 4lrhD-5htpA:
undetectable		 4lrhD-5htpA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		5 / 12 ALA A  16
ALA A  67
ALA A 224
GLY A 406
LEU A 410
 None
 1.07A 4oaeA-5htpA:
undetectable		 4oaeA-5htpA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		5 / 12 GLY A 242
GLY A 281
ILE A 397
GLY A 376
GLY A 375
 ANP  A 501 (-3.3A)
ANP  A 501 (-3.4A)
None
ANP  A 501 (-3.6A)
ANP  A 501 (-3.6A)
 1.09A 4yvgA-5htpA:
undetectable		 4yvgA-5htpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		4 / 8 ASP A 169
PRO A 168
TYR A 158
SER A 251
 None
 1.11A 5l1fA-5htpA:
undetectable
5l1fB-5htpA:
undetectable		 5l1fA-5htpA:
19.66
5l1fB-5htpA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		3 / 3 LEU A 186
LEU A 185
TRP A 136
 None
 0.90A 5nwuA-5htpA:
undetectable		 5nwuA-5htpA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		4 / 7 ILE A 138
LEU A  77
LEU A 132
LEU A 182
 None
 0.74A 6g9bA-5htpA:
undetectable
6g9bB-5htpA:
undetectable		 6g9bA-5htpA:
10.67
6g9bB-5htpA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		5 / 12 GLY A 269
GLY A 268
LEU A 267
GLY A 364
PRO A 168
 None
 0.94A 6gngB-5htpA:
undetectable		 6gngB-5htpA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		4 / 4 LYS A 248
LEU A 272
ALA A 237
LEU A 250
 None
 1.33A 6gnrA-5htpA:
undetectable		 6gnrA-5htpA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 5htp PROBABLE SUGAR
KINASE
(Synechococcus
elongatus) 		4 / 4 LYS A 248
LEU A 272
ALA A 237
LEU A 250
 None
 1.30A 6gnrB-5htpA:
undetectable		 6gnrB-5htpA:
14.45