SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5htv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		5 / 12 LEU A 214
LEU A 164
LEU A 163
LEU A  15
MET A  17
 None
 1.24A 1a28B-5htvA:
undetectable		 1a28B-5htvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		4 / 5 SER A 292
THR A 294
GLU A 333
GLY A 332
 None
 1.29A 1icrA-5htvA:
undetectable
1icrB-5htvA:
undetectable		 1icrA-5htvA:
20.14
1icrB-5htvA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		4 / 5 GLU A 333
GLY A 332
SER A 292
THR A 294
 None
 1.30A 1icrA-5htvA:
undetectable
1icrB-5htvA:
undetectable		 1icrA-5htvA:
20.14
1icrB-5htvA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		4 / 5 SER A 292
THR A 294
GLU A 333
GLY A 332
 None
 1.31A 1icvC-5htvA:
undetectable
1icvD-5htvA:
undetectable		 1icvC-5htvA:
20.14
1icvD-5htvA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		5 / 10 GLU A 384
ALA A 383
LEU A 408
PRO A 409
GLY A 369
 None
 1.23A 1mjqG-5htvA:
undetectable
1mjqH-5htvA:
undetectable		 1mjqG-5htvA:
13.54
1mjqH-5htvA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		6 / 12 ALA A 239
ALA A 422
LEU A 242
ALA A 243
CYH A 231
LEU A 161
 None
 1.26A 1xiuA-5htvA:
undetectable		 1xiuA-5htvA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		4 / 5 LEU A  13
GLY A  39
PRO A  70
VAL A  73
 None
 0.90A 2aojA-5htvA:
undetectable		 2aojA-5htvA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		6 / 12 ALA A 246
LEU A 287
SER A 266
THR A 254
ILE A 262
LEU A 375
 None
 1.47A 2oipA-5htvA:
undetectable		 2oipA-5htvA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		6 / 12 ALA A 246
LEU A 287
SER A 266
THR A 254
ILE A 262
LEU A 375
 None
 1.46A 2oipD-5htvA:
undetectable		 2oipD-5htvA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		6 / 12 ALA A 246
LEU A 287
SER A 266
THR A 254
ILE A 262
LEU A 375
 None
 1.48A 2oipE-5htvA:
undetectable		 2oipE-5htvA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		4 / 6 ILE A 401
PRO A 327
LEU A 299
ILE A 360
 None
None
ANP  A 501 ( 4.5A)
None
 0.96A 2q83B-5htvA:
undetectable		 2q83B-5htvA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		4 / 7 ILE A 364
PHE A 356
PHE A 303
GLY A 392
 None
None
None
ANP  A 501 ( 3.9A)
 1.02A 3em0B-5htvA:
undetectable		 3em0B-5htvA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		6 / 12 ALA A 246
LEU A 287
SER A 266
THR A 254
ILE A 262
LEU A 375
 None
 1.47A 3hj3B-5htvA:
undetectable		 3hj3B-5htvA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		5 / 12 VAL A 253
ALA A 261
PHE A 241
LEU A 282
TYR A 372
 None
 1.17A 3hj3C-5htvA:
undetectable		 3hj3C-5htvA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		4 / 8 PHE A 222
LEU A 164
PHE A  63
LEU A  62
 None
 0.94A 3i45A-5htvA:
undetectable		 3i45A-5htvA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		5 / 7 GLN A 329
SER A 258
LEU A 361
ARG A 300
ILE A 298
 None
ANP  A 501 (-3.3A)
None
ANP  A 501 (-4.2A)
None
 1.41A 3ln1C-5htvA:
undetectable		 3ln1C-5htvA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		5 / 12 THR A 234
THR A 247
ASP A 283
LEU A 425
GLY A 208
 None
 1.16A 3n58C-5htvA:
undetectable		 3n58C-5htvA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		5 / 12 THR A 234
THR A 247
ASP A 283
LEU A 425
GLY A 208
 None
 1.18A 3ondA-5htvA:
undetectable		 3ondA-5htvA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		5 / 12 THR A 234
THR A 247
ASP A 283
LEU A 425
GLY A 208
 None
 1.19A 3ondB-5htvA:
undetectable		 3ondB-5htvA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		3 / 3 TYR A 420
HIS A 415
ARG A 245
 None
 1.08A 4e7bC-5htvA:
undetectable		 4e7bC-5htvA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		3 / 3 HIS A 280
TRP A 286
SER A  86
 None
 1.22A 4lrhD-5htvA:
undetectable		 4lrhD-5htvA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		5 / 12 THR A 234
THR A 247
ASP A 283
LEU A 425
GLY A 208
 None
 1.22A 5axdA-5htvA:
undetectable		 5axdA-5htvA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		5 / 12 THR A 234
THR A 247
ASP A 283
LEU A 425
GLY A 208
 None
 1.21A 5axdC-5htvA:
undetectable		 5axdC-5htvA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		5 / 12 THR A 234
THR A 247
ASP A 283
LEU A 425
GLY A 208
 None
 1.21A 5m66A-5htvA:
undetectable		 5m66A-5htvA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		5 / 12 THR A 234
THR A 247
ASP A 283
LEU A 425
GLY A 208
 None
 1.16A 5m66C-5htvA:
undetectable		 5m66C-5htvA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		5 / 12 THR A 234
THR A 247
ASP A 283
LEU A 425
GLY A 208
 None
 1.21A 5utuF-5htvA:
undetectable		 5utuF-5htvA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		4 / 8 GLY A 379
ARG A 274
VAL A 270
ASP A 272
 None
 0.98A 5vlmA-5htvA:
undetectable		 5vlmA-5htvA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		5 / 12 THR A 234
THR A 247
ASP A 283
LEU A 425
GLY A 208
 None
 1.12A 6f3nB-5htvA:
undetectable		 6f3nB-5htvA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		4 / 4 LYS A 263
LEU A 287
ALA A 252
LEU A 265
 None
 1.17A 6gnrA-5htvA:
undetectable		 6gnrA-5htvA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 5htv PUTATIVE XYLULOSE
KINASE
(Arabidopsis
thaliana) 		4 / 4 LYS A 263
LEU A 287
ALA A 252
LEU A 265
 None
 1.16A 6gnrB-5htvA:
undetectable		 6gnrB-5htvA:
17.10