SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hu3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		10 / 12 LEU A  20
GLY A  21
VAL A  28
ALA A  41
VAL A  74
VAL A  93
GLU A  97
ASN A 141
LEU A 143
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.0A)
ADP  A 301 (-3.5A)
MG  A 302 ( 2.8A)
ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
 0.58A 1fmoE-5hu3A:
31.0		 1fmoE-5hu3A:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
VAL A  28
ALA A  41
GLU A  61
GLY A  96
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.84A 1iepA-5hu3A:
22.8		 1iepA-5hu3A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 LEU A  20
VAL A  28
ALA A  41
GLU A  61
GLY A  95
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 ( 4.8A)
 0.98A 1iepB-5hu3A:
13.5		 1iepB-5hu3A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 LEU A  20
VAL A  28
ALA A  41
GLU A  61
GLY A  96
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 ( 4.8A)
 0.77A 1iepB-5hu3A:
13.5		 1iepB-5hu3A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
ALA A  41
LYS A  43
GLU A  61
LEU A  88
LEU A  92
GLY A  96
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-4.7A)
 0.76A 1m17A-5hu3A:
25.8		 1m17A-5hu3A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
VAL A  28
ALA A  41
GLU A  61
VAL A  74
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.73A 1opjA-5hu3A:
23.0		 1opjA-5hu3A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 VAL A  28
ALA A  41
GLU A  61
VAL A  74
GLY A  96
ALA A 156
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
None
ADP  A 301 ( 4.8A)
 0.76A 1opjB-5hu3A:
16.6		 1opjB-5hu3A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		4 / 5 ILE A 249
TRP A 238
LEU A 253
PRO A 213
 None
 1.25A 1s8fA-5hu3A:
undetectable
1s8fB-5hu3A:
undetectable		 1s8fA-5hu3A:
22.07
1s8fB-5hu3A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
VAL A  74
GLY A  96
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
None
ADP  A 301 (-4.7A)
 0.75A 1t46A-5hu3A:
23.2		 1t46A-5hu3A:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 9 LEU A  20
VAL A  28
LEU A  76
LEU A  88
LEU A  92
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
None
None
ADP  A 301 ( 4.8A)
 0.46A 1xkkA-5hu3A:
16.7		 1xkkA-5hu3A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 9 VAL A  28
LYS A  43
LEU A  76
LEU A  88
LEU A  92
 ADP  A 301 (-3.7A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 ( 4.8A)
 0.75A 1xkkA-5hu3A:
16.7		 1xkkA-5hu3A:
24.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		9 / 12 VAL A  28
LYS A  43
VAL A  74
PHE A  90
VAL A  93
ASN A 141
LEU A 143
ALA A 156
ASP A 157
 ADP  A 301 (-3.7A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 (-4.0A)
MG  A 302 ( 2.8A)
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
MG  A 302 ( 3.3A)
 0.68A 2eufB-5hu3A:
29.4		 2eufB-5hu3A:
31.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
GLY A  21
VAL A  28
ALA A  41
VAL A  93
LYS A 138
ASN A 141
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-4.0A)
TPO  B 787 ( 2.7A)
MG  A 302 ( 2.8A)
 0.51A 2fumA-5hu3A:
30.5		 2fumA-5hu3A:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
GLY A  21
VAL A  28
ALA A  41
VAL A  93
LYS A 138
ASN A 141
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-4.0A)
TPO  B 787 ( 2.7A)
MG  A 302 ( 2.8A)
 0.52A 2fumB-5hu3A:
30.4		 2fumB-5hu3A:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 LEU A  20
GLY A  21
VAL A  28
ALA A  41
VAL A  93
ASN A 141
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-4.0A)
MG  A 302 ( 2.8A)
 0.45A 2fumC-5hu3A:
28.6		 2fumC-5hu3A:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
GLY A  21
GLY A  23
VAL A  28
ALA A  41
LYS A 138
ASN A 141
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-2.8A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
TPO  B 787 ( 2.7A)
MG  A 302 ( 2.8A)
 0.80A 2fumD-5hu3A:
28.7		 2fumD-5hu3A:
32.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
VAL A  28
ALA A  41
GLU A  61
VAL A  74
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.62A 2gqgB-5hu3A:
26.8		 2gqgB-5hu3A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
VAL A  28
ALA A  41
VAL A  74
GLY A  96
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.63A 2gqgB-5hu3A:
26.8		 2gqgB-5hu3A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 VAL A  28
ALA A  41
GLU A  61
GLY A  96
LEU A 143
ALA A 156
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.79A 2hyyA-5hu3A:
23.2		 2hyyA-5hu3A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 VAL A  28
ALA A  41
GLU A  61
GLY A  96
LEU A 143
ALA A 156
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.74A 2hyyB-5hu3A:
23.1		 2hyyB-5hu3A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 VAL A  28
ALA A  41
GLU A  61
VAL A  74
GLY A  96
LEU A 143
ALA A 156
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.60A 2hyyC-5hu3A:
23.4		 2hyyC-5hu3A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
ALA A  41
LYS A  43
GLU A  61
LEU A  88
GLY A  96
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
None
ADP  A 301 (-4.7A)
 0.87A 2itoA-5hu3A:
24.9		 2itoA-5hu3A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
GLY A  96
LEU A 143
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
 0.92A 2itzA-5hu3A:
24.9		 2itzA-5hu3A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 9 LEU A  20
VAL A  28
ALA A  41
GLY A  96
LEU A 143
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
 0.77A 2xp2A-5hu3A:
7.4		 2xp2A-5hu3A:
26.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 VAL A  28
ALA A  41
PHE A  90
LEU A  92
GLY A  96
GLU A  97
LEU A 143
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-3.5A)
ADP  A 301 (-4.7A)
 0.35A 2y7jA-5hu3A:
35.8		 2y7jA-5hu3A:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 10 VAL A  28
ALA A  41
PHE A  90
LEU A  92
GLY A  96
LEU A 143
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-4.7A)
 0.38A 2y7jB-5hu3A:
36.3		 2y7jB-5hu3A:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 10 VAL A  28
ALA A  41
PHE A  90
LEU A  92
GLY A  96
LEU A 143
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-4.7A)
 0.37A 2y7jC-5hu3A:
35.9		 2y7jC-5hu3A:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 10 VAL A  28
ALA A  41
PHE A  90
LEU A  92
GLY A  96
LEU A 143
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-4.7A)
 0.46A 2y7jD-5hu3A:
35.8		 2y7jD-5hu3A:
34.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 10 LEU A  20
ALA A  41
LYS A  43
VAL A  74
LEU A  92
GLY A  96
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-4.7A)
 0.84A 3aoxA-5hu3A:
24.2		 3aoxA-5hu3A:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 VAL A  28
ALA A  41
LEU A  76
LEU A  92
GLY A  96
LEU A 143
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-4.7A)
 0.66A 3bbtB-5hu3A:
23.0		 3bbtB-5hu3A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
POTASSIUM
VOLTAGE-GATED
CHANNEL PROTEIN EAG
(Drosophila
melanogaster) 		5 / 12 ILE B 788
SER A 182
PRO A 213
PHE A 214
LEU A 222
 TPO  B 787 ( 3.8A)
None
None
None
None
 1.16A 3cd2A-5hu3B:
undetectable		 3cd2A-5hu3B:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
GLY A  21
GLY A  23
VAL A  28
ALA A  41
LYS A  43
ASN A 141
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-2.8A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
MG  A 302 ( 2.8A)
ADP  A 301 (-4.7A)
 0.66A 3eygA-5hu3A:
27.0		 3eygA-5hu3A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
VAL A  74
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.83A 3g5dB-5hu3A:
24.9		 3g5dB-5hu3A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
VAL A  28
ALA A  41
LYS A  43
VAL A  74
GLY A  96
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.80A 3g5dB-5hu3A:
24.9		 3g5dB-5hu3A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
VAL A  28
ALA A  41
GLU A  61
VAL A  74
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.73A 3gvuA-5hu3A:
23.3		 3gvuA-5hu3A:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		4 / 6 GLN A 119
LEU A 121
GLU A 122
LEU A 267
 None
 0.81A 3h5gA-5hu3A:
undetectable
3h5gC-5hu3A:
undetectable		 3h5gA-5hu3A:
8.07
3h5gC-5hu3A:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 12 ALA A  41
GLU A  61
VAL A  74
LEU A 143
ALA A 156
 ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.57A 3ik3A-5hu3A:
23.2		 3ik3A-5hu3A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 12 ALA A  41
VAL A  74
HIS A 134
LEU A 143
ALA A 156
 ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.40A 3ik3A-5hu3A:
23.2		 3ik3A-5hu3A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 12 ALA A  41
GLU A  61
VAL A  74
LEU A 143
ALA A 156
 ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.59A 3ik3B-5hu3A:
12.5		 3ik3B-5hu3A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 12 ALA A  41
VAL A  74
HIS A 134
LEU A 143
ALA A 156
 ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.42A 3ik3B-5hu3A:
12.5		 3ik3B-5hu3A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		3 / 3 GLU A 237
ASP A 239
ASP A 232
 None
 0.52A 3jb2A-5hu3A:
undetectable		 3jb2A-5hu3A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 12 LEU A 143
ASP A 157
GLU A  97
ALA A  24
GLU A 140
 ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
ADP  A 301 (-3.5A)
TPO  B 787 (-3.1A)
None
 1.49A 3k39D-5hu3A:
undetectable		 3k39D-5hu3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 12 LEU A 143
ASP A 157
GLU A  97
ALA A  24
GLU A 140
 ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
ADP  A 301 (-3.5A)
TPO  B 787 (-3.1A)
None
 1.49A 3k39I-5hu3A:
undetectable		 3k39I-5hu3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 12 LEU A 143
ASP A 157
GLU A  97
ALA A  24
GLU A 140
 ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
ADP  A 301 (-3.5A)
TPO  B 787 (-3.1A)
None
 1.48A 3k39J-5hu3A:
undetectable		 3k39J-5hu3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 12 LEU A 143
ASP A 157
GLU A  97
ALA A  24
GLU A 140
 ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
ADP  A 301 (-3.5A)
TPO  B 787 (-3.1A)
None
 1.48A 3k39L-5hu3A:
undetectable		 3k39L-5hu3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 VAL A  28
ALA A  41
GLU A  61
GLY A  96
LEU A 143
ALA A 156
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.75A 3k5vA-5hu3A:
16.6		 3k5vA-5hu3A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 VAL A  28
ALA A  41
GLU A  61
GLY A  96
LEU A 143
ALA A 156
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.73A 3k5vB-5hu3A:
16.6		 3k5vB-5hu3A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 8 ALA A  41
LYS A  43
GLU A  61
LEU A  88
LEU A  92
 ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 ( 4.8A)
 0.43A 3lfaA-5hu3A:
22.7		 3lfaA-5hu3A:
29.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
GLY A  21
GLY A  23
VAL A  28
ALA A  41
VAL A  93
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-2.8A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-4.0A)
ADP  A 301 (-4.7A)
 0.57A 3lxnA-5hu3A:
27.1		 3lxnA-5hu3A:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 LEU A  20
VAL A  28
ALA A  41
GLU A  61
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.87A 3ms9A-5hu3A:
22.5		 3ms9A-5hu3A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
VAL A  28
ALA A  41
GLU A  61
GLY A  96
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.81A 3ms9B-5hu3A:
22.5		 3ms9B-5hu3A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 LEU A  20
VAL A  28
ALA A  41
GLU A  61
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.89A 3mssA-5hu3A:
22.7		 3mssA-5hu3A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 LEU A  20
VAL A  28
ALA A  41
GLU A  61
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.89A 3mssC-5hu3A:
22.6		 3mssC-5hu3A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 LEU A  20
ALA A  41
GLU A  61
GLY A  96
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.79A 3mssD-5hu3A:
17.1		 3mssD-5hu3A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		4 / 5 VAL A 124
LEU A 121
ILE A 203
ALA A 199
 None
 0.88A 3n8yB-5hu3A:
undetectable		 3n8yB-5hu3A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 ALA A  41
GLU A  61
VAL A  74
GLY A  96
HIS A 134
ALA A 156
ASP A 157
 ADP  A 301 (-3.5A)
None
None
None
None
ADP  A 301 ( 4.8A)
MG  A 302 ( 3.3A)
 1.07A 3oxzA-5hu3A:
23.0		 3oxzA-5hu3A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
VAL A  28
ALA A  41
GLU A  61
VAL A  74
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.69A 3pyyB-5hu3A:
22.8		 3pyyB-5hu3A:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
VAL A  28
ALA A  41
GLU A  61
VAL A  74
GLY A  96
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.78A 3qlgB-5hu3A:
24.8		 3qlgB-5hu3A:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
VAL A  28
ALA A  41
LYS A  43
LEU A  88
LEU A  92
GLY A  96
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
ADP  A 301 ( 4.8A)
None
 0.89A 3ug2A-5hu3A:
24.8		 3ug2A-5hu3A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 VAL A  28
ALA A  41
LYS A  43
LEU A  88
LEU A  92
GLY A  96
LEU A 143
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-4.7A)
 0.87A 3ug2A-5hu3A:
24.8		 3ug2A-5hu3A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		4 / 8 VAL A  28
LYS A  43
PHE A  90
ASP A 157
 ADP  A 301 (-3.7A)
ADP  A 301 (-2.7A)
None
MG  A 302 ( 3.3A)
 0.48A 3warA-5hu3A:
27.5		 3warA-5hu3A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		4 / 5 ILE A  64
VAL A  74
LEU A 143
ASP A 157
 None
None
ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
 1.06A 3wzdA-5hu3A:
22.9		 3wzdA-5hu3A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
GLY A  96
HIS A 134
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
None
 0.71A 3wzeA-5hu3A:
22.9		 3wzeA-5hu3A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
ALA A  41
LYS A  43
GLU A  61
HIS A 134
ARG A 135
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.90A 3zosA-5hu3A:
22.5		 3zosA-5hu3A:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
VAL A  74
GLY A  96
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
None
ADP  A 301 (-4.7A)
 0.64A 4ag8A-5hu3A:
22.8		 4ag8A-5hu3A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
GLY A  96
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 (-4.7A)
 0.63A 4agcA-5hu3A:
22.3		 4agcA-5hu3A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 9 LEU A  20
VAL A  28
ALA A  41
GLY A  96
LEU A 143
ALA A 156
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
MG  A 302 ( 3.3A)
 0.82A 4anqA-5hu3A:
24.8		 4anqA-5hu3A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 9 LEU A  20
VAL A  28
ALA A  41
GLY A  96
LEU A 143
ALA A 156
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
MG  A 302 ( 3.3A)
 0.86A 4ansA-5hu3A:
24.7		 4ansA-5hu3A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 ALA A  41
LYS A  43
GLU A  61
ILE A  73
HIS A 134
LEU A 143
ALA A 156
 ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.58A 4c8bB-5hu3A:
24.4		 4c8bB-5hu3A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 VAL A  28
ALA A  41
GLU A  61
ILE A  64
VAL A  74
LEU A 143
ALA A 156
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.90A 4csvA-5hu3A:
23.9		 4csvA-5hu3A:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 11 VAL A  28
ALA A  41
LYS A  43
GLU A 140
LEU A 143
ASP A 157
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
 0.99A 4iaaA-5hu3A:
29.0		 4iaaA-5hu3A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
VAL A  28
ALA A  41
VAL A  74
GLY A  96
LEU A 143
ALA A 156
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
MG  A 302 ( 3.3A)
 0.94A 4mxyB-5hu3A:
25.3		 4mxyB-5hu3A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
VAL A  28
ALA A  41
VAL A  74
GLY A  96
LEU A 143
ALA A 156
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
MG  A 302 ( 3.3A)
 0.94A 4mxzB-5hu3A:
25.3		 4mxzB-5hu3A:
26.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 6 LEU A  20
GLY A  21
VAL A  28
ALA A  41
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-4.7A)
 0.38A 4o0wA-5hu3A:
31.5		 4o0wA-5hu3A:
32.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
GLY A  21
GLY A  23
VAL A  28
ALA A  41
LYS A  43
VAL A  74
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-2.8A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
ADP  A 301 ( 4.8A)
 0.56A 4otiA-5hu3A:
23.8		 4otiA-5hu3A:
29.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
GLY A  21
GLY A  23
VAL A  28
ALA A  41
VAL A  74
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-2.8A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.58A 4otiA-5hu3A:
23.8		 4otiA-5hu3A:
29.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
VAL A  28
LYS A  43
VAL A  74
GLY A  96
LEU A 143
ALA A 156
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
MG  A 302 ( 3.3A)
 1.03A 4otwA-5hu3A:
23.0		 4otwA-5hu3A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 10 ALA A  41
LYS A  43
LEU A  92
VAL A  93
LEU A 143
 ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
ADP  A 301 ( 4.8A)
ADP  A 301 (-4.0A)
ADP  A 301 (-4.7A)
 0.51A 4rz7A-5hu3A:
11.4		 4rz7A-5hu3A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
VAL A  28
ALA A  41
GLY A  96
ASN A 141
LEU A 143
ALA A 156
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
MG  A 302 ( 2.8A)
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
MG  A 302 ( 3.3A)
 0.62A 4twpA-5hu3A:
26.1		 4twpA-5hu3A:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLY A  96
LEU A 143
ALA A 156
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
MG  A 302 ( 3.3A)
 0.69A 4twpA-5hu3A:
26.1		 4twpA-5hu3A:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
VAL A  28
ALA A  41
GLY A  96
ASN A 141
LEU A 143
ALA A 156
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
MG  A 302 ( 2.8A)
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
MG  A 302 ( 3.3A)
 0.59A 4twpB-5hu3A:
26.2		 4twpB-5hu3A:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 12 ALA A  41
GLU A  61
HIS A 134
LEU A 143
ALA A 156
 ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.58A 4tyjA-5hu3A:
23.5		 4tyjA-5hu3A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 10 LEU A  20
VAL A  28
GLU A  61
LEU A  68
ILE A  73
VAL A  74
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
None
None
None
None
 0.77A 4u0iA-5hu3A:
23.0		 4u0iA-5hu3A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 11 LEU A  20
VAL A  28
ALA A  41
GLY A  96
ASN A 141
LEU A 143
ALA A 156
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
MG  A 302 ( 2.8A)
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
MG  A 302 ( 3.3A)
 0.55A 4u5jA-5hu3A:
26.8		 4u5jA-5hu3A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 12 LEU A  20
ALA A  41
HIS A 134
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.60A 4uxqA-5hu3A:
23.2		 4uxqA-5hu3A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 VAL A  28
ALA A  41
GLU A  61
HIS A 134
ALA A 156
GLY A 159
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 ( 4.8A)
None
 1.30A 4v04A-5hu3A:
22.7		 4v04A-5hu3A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
ALA A  41
LYS A  43
GLU A  61
LEU A  88
LEU A  92
GLY A  96
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-4.7A)
 0.73A 4wkqA-5hu3A:
26.0		 4wkqA-5hu3A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
ALA A  41
LYS A  43
GLU A  61
VAL A  74
GLY A  96
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.86A 4xliB-5hu3A:
26.8		 4xliB-5hu3A:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 9 LEU A  20
VAL A  28
ALA A  41
GLY A  96
LEU A 143
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
 0.81A 5aaaA-5hu3A:
25.1		 5aaaA-5hu3A:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 10 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLY A  96
LEU A 143
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
 0.98A 5aabA-5hu3A:
24.7		 5aabA-5hu3A:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 LEU A  20
ALA A  41
GLY A  96
LEU A 143
ALA A 156
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
MG  A 302 ( 3.3A)
 0.60A 5ajqA-5hu3A:
26.1		 5ajqA-5hu3A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
GLY A  96
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.76A 5bvwA-5hu3A:
22.8		 5bvwA-5hu3A:
25.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 GLY A  21
VAL A  28
ALA A  41
VAL A  74
PHE A  90
LEU A 143
ALA A 156
 ADP  A 301 (-3.6A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.69A 5l2iA-5hu3A:
7.9		 5l2iA-5hu3A:
31.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 GLY A  21
VAL A  28
ALA A  41
VAL A  74
PHE A  90
ALA A 156
 ADP  A 301 (-3.6A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 ( 4.8A)
 0.83A 5l2tA-5hu3A:
7.8		 5l2tA-5hu3A:
31.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 11 LEU A  20
GLY A  21
VAL A  28
ALA A  41
VAL A  74
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.7A)
 0.50A 5lvnA-5hu3A:
32.3		 5lvnA-5hu3A:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 GLU A  18
VAL A  28
ALA A  41
LYS A  43
GLU A  61
GLY A  96
GLU A  97
 None
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 (-3.5A)
 0.81A 5mafA-5hu3A:
31.8		 5mafA-5hu3A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 12 ALA A  41
VAL A  74
HIS A 134
LEU A 143
ALA A 156
 ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.43A 5mo4A-5hu3A:
19.0		 5mo4A-5hu3A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 10 LEU A  20
VAL A  28
ALA A  41
VAL A  74
VAL A  93
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.0A)
ADP  A 301 (-4.7A)
 0.54A 5n3hA-5hu3A:
30.5		 5n3hA-5hu3A:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		4 / 8 LEU A  98
ALA A 199
GLN A 119
HIS A 134
 None
 0.93A 5nu7A-5hu3A:
undetectable		 5nu7A-5hu3A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS8_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		4 / 5 LYS A  57
ARG A  60
ARG A 135
LEU A 160
 None
None
None
TPO  B 787 ( 4.7A)
 0.95A 5os8A-5hu3A:
27.0		 5os8A-5hu3A:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		4 / 8 ALA A  41
GLU A  61
LEU A 143
ASP A 157
 ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
 0.39A 5owrA-5hu3A:
23.9		 5owrA-5hu3A:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 GLU A  18
ALA A  41
GLU A  61
VAL A  74
GLY A  96
LEU A 143
 None
ADP  A 301 (-3.5A)
None
None
None
ADP  A 301 (-4.7A)
 0.69A 5te0A-5hu3A:
28.3		 5te0A-5hu3A:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 LEU A  20
ALA A  41
LYS A  43
GLU A  61
LEU A  88
GLY A  96
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
None
 1.22A 5vcvA-5hu3A:
28.2		 5vcvA-5hu3A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
GLY A  95
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
 0.88A 5vcyA-5hu3A:
28.2		 5vcyA-5hu3A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
LEU A  88
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
 0.45A 5vcyA-5hu3A:
28.2		 5vcyA-5hu3A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		4 / 4 VAL A  74
LEU A  92
ASN A 141
ASP A 157
 None
ADP  A 301 ( 4.8A)
MG  A 302 ( 2.8A)
MG  A 302 ( 3.3A)
 0.93A 5vcyA-5hu3A:
28.2		 5vcyA-5hu3A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		4 / 6 MET A 252
ASN A 258
VAL A 255
LEU A 253
 None
 1.31A 5xdhA-5hu3A:
0.6
5xdhC-5hu3A:
undetectable		 5xdhA-5hu3A:
18.31
5xdhC-5hu3A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 12 LEU A  20
GLY A  21
VAL A  28
ALA A  41
PHE A  90
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
 0.31A 5xv7A-5hu3A:
27.6		 5xv7A-5hu3A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
LEU A  92
GLY A  96
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-4.7A)
 0.81A 5y7zA-5hu3A:
27.2		 5y7zA-5hu3A:
15.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
LEU A  92
GLY A  96
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-4.7A)
 0.81A 5y7zA-5hu3A:
27.2		 5y7zA-5hu3A:
32.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 VAL A  28
ALA A  41
LYS A  43
GLU A  61
GLY A  96
GLU A 100
LEU A 143
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
None
ADP  A 301 (-4.7A)
 0.95A 5y7zA-5hu3A:
27.2		 5y7zA-5hu3A:
15.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 VAL A  28
ALA A  41
LYS A  43
GLU A  61
GLY A  96
GLU A 100
LEU A 143
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
None
ADP  A 301 (-4.7A)
 0.95A 5y7zA-5hu3A:
27.2		 5y7zA-5hu3A:
32.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
ALA A  41
GLU A  61
LEU A  88
LEU A  92
LEU A 143
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 ( 4.8A)
ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
 0.75A 5y7zB-5hu3A:
19.6		 5y7zB-5hu3A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
ALA A  41
GLU A  61
LEU A  92
GLY A  96
LEU A 143
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
 0.74A 5y7zB-5hu3A:
19.6		 5y7zB-5hu3A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
ALA A  41
LYS A  43
GLU A  61
LEU A  88
LEU A  92
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 ( 4.8A)
MG  A 302 ( 3.3A)
 0.75A 5y7zB-5hu3A:
19.6		 5y7zB-5hu3A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
ALA A  41
LYS A  43
GLU A  61
LEU A  92
GLY A  96
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
ADP  A 301 ( 4.8A)
None
MG  A 302 ( 3.3A)
 0.82A 5y7zB-5hu3A:
19.6		 5y7zB-5hu3A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
VAL A  28
ALA A  41
GLU A  61
LEU A  92
GLY A  96
LEU A 143
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
 0.66A 5y80A-5hu3A:
26.3		 5y80A-5hu3A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		8 / 12 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
LEU A  92
GLY A  96
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
ADP  A 301 ( 4.8A)
None
MG  A 302 ( 3.3A)
 0.75A 5y80A-5hu3A:
26.3		 5y80A-5hu3A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		4 / 8 VAL A  28
LYS A  43
PHE A  90
ASP A 157
 ADP  A 301 (-3.7A)
ADP  A 301 (-2.7A)
None
MG  A 302 ( 3.3A)
 0.32A 5y9mX-5hu3A:
27.1		 5y9mX-5hu3A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		4 / 7 VAL A  28
LYS A  43
PHE A  90
ASP A 157
 ADP  A 301 (-3.7A)
ADP  A 301 (-2.7A)
None
MG  A 302 ( 3.3A)
 0.55A 5yf9B-5hu3A:
27.1		 5yf9B-5hu3A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		4 / 7 VAL A  28
LYS A  43
PHE A  90
ASP A 157
 ADP  A 301 (-3.7A)
ADP  A 301 (-2.7A)
None
MG  A 302 ( 3.3A)
 0.39A 5ywmX-5hu3A:
27.6		 5ywmX-5hu3A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		6 / 12 LEU A  20
VAL A  28
ALA A  41
GLU A  61
GLY A  96
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 ( 4.8A)
 0.67A 5zv2A-5hu3A:
23.1		 5zv2A-5hu3A:
14.39