SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hu4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 5hu4 CYSTEINE PROTEASE
(Listeria
monocytogenes) 		5 / 11 LEU A  79
GLY A 131
ASP A  75
VAL A  15
ILE A 115
 None
 0.92A 1hxwB-5hu4A:
undetectable		 1hxwB-5hu4A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5hu4 CYSTEINE PROTEASE
(Listeria
monocytogenes) 		4 / 7 PHE A  65
GLY A 131
ILE A  68
VAL A  71
 None
 0.81A 1p2yA-5hu4A:
undetectable		 1p2yA-5hu4A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5hu4 CYSTEINE PROTEASE
(Listeria
monocytogenes) 		4 / 7 LEU A  53
ILE A  77
ILE A  68
PHE A 148
 None
 0.89A 1uwjA-5hu4A:
undetectable		 1uwjA-5hu4A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 5hu4 CYSTEINE PROTEASE
(Listeria
monocytogenes) 		5 / 12 LEU A  79
GLY A 131
ASP A  75
VAL A  15
ILE A 115
 None
 0.91A 2ieoA-5hu4A:
undetectable		 2ieoA-5hu4A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 5hu4 CYSTEINE PROTEASE
(Listeria
monocytogenes) 		5 / 12 LEU A  79
GLY A 131
ASP A  75
VAL A  15
ILE A 115
 None
 0.87A 3cywA-5hu4A:
undetectable		 3cywA-5hu4A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 5hu4 CYSTEINE PROTEASE
(Listeria
monocytogenes) 		5 / 10 LEU A  79
GLY A 131
ASP A  75
VAL A  15
ILE A 115
 None
 0.90A 3ekpD-5hu4A:
undetectable		 3ekpD-5hu4A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 5hu4 CYSTEINE PROTEASE
(Listeria
monocytogenes) 		5 / 9 LEU A  79
GLY A 131
ASP A  75
VAL A  15
ILE A 115
 None
 0.96A 3ektA-5hu4A:
undetectable		 3ektA-5hu4A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 5hu4 CYSTEINE PROTEASE
(Listeria
monocytogenes) 		4 / 6 SER A  62
LEU A  64
HIS A  56
MET A  58
 None
 1.28A 3thrB-5hu4A:
undetectable		 3thrB-5hu4A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5hu4 CYSTEINE PROTEASE
(Listeria
monocytogenes) 		5 / 12 VAL A  18
ALA A  37
PHE A  65
ILE A  77
LEU A  79
 None
 1.07A 3w67C-5hu4A:
undetectable		 3w67C-5hu4A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 5hu4 CYSTEINE PROTEASE
(Listeria
monocytogenes) 		5 / 11 ILE A 112
ALA A  54
LEU A  53
THR A  38
VAL A  24
 None
 1.14A 4g1bB-5hu4A:
undetectable		 4g1bB-5hu4A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 5hu4 CYSTEINE PROTEASE
(Listeria
monocytogenes) 		5 / 12 LEU A  79
GLY A 131
ASP A  75
VAL A  15
ILE A 115
 None
 0.86A 4jecB-5hu4A:
undetectable		 4jecB-5hu4A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 5hu4 CYSTEINE PROTEASE
(Listeria
monocytogenes) 		5 / 11 GLY A  49
ALA A 110
ASP A 109
ILE A  77
THR A 136
 None
 1.15A 4l1aA-5hu4A:
undetectable		 4l1aA-5hu4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5hu4 CYSTEINE PROTEASE
(Listeria
monocytogenes) 		5 / 12 LEU A  82
GLU A  83
GLY A  47
ALA A 110
GLU A 132
 None
 1.15A 4retA-5hu4A:
undetectable		 4retA-5hu4A:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5hu4 CYSTEINE PROTEASE
(Listeria
monocytogenes) 		5 / 12 LEU A  82
GLU A  83
GLY A  47
ALA A 110
GLU A 132
 None
 1.15A 4retC-5hu4A:
undetectable		 4retC-5hu4A:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 5hu4 CYSTEINE PROTEASE
(Listeria
monocytogenes) 		4 / 6 ASP A  97
PRO A  52
THR A 113
VAL A 128
 None
 1.15A 4yoaA-5hu4A:
undetectable		 4yoaA-5hu4A:
22.31