SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hu6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 5hu6 HEMOGLOBIN SUBUNIT
BETA
(Homo
sapiens) 		4 / 7 PHE B  43
PHE B  46
VAL B  68
HIS B  93
 HEM  B 201 ( 4.4A)
None
HEM  B 201 ( 3.6A)
HEM  B 201 (-3.5A)
 0.90A 1lh6A-5hu6B:
13.4		 1lh6A-5hu6B:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 5hu6 HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR
(Trypanosoma
brucei) 		5 / 12 ALA D 225
GLY D 222
GLY D 221
ASP D 232
GLY D 231
 None
 1.00A 1sqfA-5hu6D:
undetectable		 1sqfA-5hu6D:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5hu6 HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR
(Trypanosoma
brucei) 		4 / 5 ALA D 170
ALA D 213
ALA D 216
VAL D 220
 None
 0.90A 2nyrB-5hu6D:
undetectable		 2nyrB-5hu6D:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 5hu6 HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR
(Trypanosoma
brucei) 		4 / 4 LEU D 157
ASP D 147
VAL D 247
THR D  69
 None
 1.26A 3cyxB-5hu6D:
undetectable		 3cyxB-5hu6D:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5hu6 HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR
(Trypanosoma
brucei) 		5 / 12 TYR D  66
ALA D 155
GLY D 159
SER D 161
LEU D 239
 None
 1.45A 3ou6D-5hu6D:
undetectable		 3ou6D-5hu6D:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 5hu6 HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR
(Trypanosoma
brucei) 		5 / 12 LEU D  97
VAL D 100
ALA D 278
GLU D 130
ALA D 128
 None
 1.24A 4fiaA-5hu6D:
undetectable		 4fiaA-5hu6D:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5hu6 HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR
(Trypanosoma
brucei) 		5 / 12 LEU D  97
VAL D 100
ALA D 278
GLU D 130
ALA D 128
 None
 1.24A 4fiaA-5hu6D:
undetectable		 4fiaA-5hu6D:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5hu6 HEMOGLOBIN SUBUNIT
BETA
(Homo
sapiens) 		4 / 5 PHE B 123
LEU B 111
VAL B 135
VAL B  12
 None
 1.14A 4l49A-5hu6B:
undetectable		 4l49A-5hu6B:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5hu6 HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR
(Trypanosoma
brucei) 		4 / 5 ALA D  52
ARG D 199
ALA D 170
GLU D 172
 None
HEM  B 201 (-3.9A)
None
None
 1.32A 5a06C-5hu6D:
undetectable
5a06D-5hu6D:
undetectable		 5a06C-5hu6D:
23.70
5a06D-5hu6D:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 5hu6 HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR
(Trypanosoma
brucei) 		5 / 12 ALA D 169
GLY D 167
GLN D  54
LEU D 210
GLU D 209
 None
 1.14A 5nwuA-5hu6D:
undetectable		 5nwuA-5hu6D:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5hu6 HEMOGLOBIN SUBUNIT
BETA
(Homo
sapiens) 		4 / 4 VAL B 134
VAL B 135
TYR B 131
GLN B 128
 None
 1.21A 5qggA-5hu6B:
undetectable		 5qggA-5hu6B:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5hu6 HEMOGLOBIN SUBUNIT
BETA
(Homo
sapiens) 		4 / 4 VAL B 134
VAL B 135
TYR B 131
GLN B 128
 None
 1.18A 5qgoA-5hu6B:
undetectable		 5qgoA-5hu6B:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5hu6 HEMOGLOBIN SUBUNIT
BETA
(Homo
sapiens) 		4 / 4 VAL B 134
VAL B 135
TYR B 131
GLN B 128
 None
 1.18A 5qgpA-5hu6B:
undetectable		 5qgpA-5hu6B:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5hu6 HEMOGLOBIN SUBUNIT
BETA
(Homo
sapiens) 		4 / 4 VAL B 134
VAL B 135
TYR B 131
GLN B 128
 None
 1.25A 5qgqA-5hu6B:
undetectable		 5qgqA-5hu6B:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5hu6 HEMOGLOBIN SUBUNIT
BETA
(Homo
sapiens) 		4 / 4 VAL B 134
VAL B 135
TYR B 131
GLN B 128
 None
 1.22A 5qhbA-5hu6B:
undetectable		 5qhbA-5hu6B:
26.01