SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hu7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 5hu7 PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		4 / 4 LEU A3082
PRO A3092
ILE A2891
LEU A2894
 None
 1.14A 1ya4B-5hu7A:
undetectable		 1ya4B-5hu7A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 5hu7 PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		4 / 6 LEU A2981
GLN A2987
GLU A2989
PRO A2984
 None
 1.10A 2fcnA-5hu7A:
undetectable
2fcnB-5hu7A:
undetectable		 2fcnA-5hu7A:
13.79
2fcnB-5hu7A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5hu7 PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		5 / 11 SER A3053
ILE A3017
VAL A3029
VAL A3020
ILE A3099
 None
 1.26A 3rf4A-5hu7A:
undetectable
3rf4C-5hu7A:
undetectable		 3rf4A-5hu7A:
15.82
3rf4C-5hu7A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5hu7 PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		5 / 11 ILE A3099
SER A3053
ILE A3017
VAL A3029
VAL A3020
 None
 1.21A 3rf4A-5hu7A:
undetectable
3rf4B-5hu7A:
undetectable		 3rf4A-5hu7A:
15.82
3rf4B-5hu7A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5hu7 PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		5 / 11 ILE A3099
SER A3053
ILE A3017
VAL A3029
VAL A3020
 None
 1.23A 3rf4B-5hu7A:
undetectable
3rf4C-5hu7A:
undetectable		 3rf4B-5hu7A:
15.82
3rf4C-5hu7A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5hu7 PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		3 / 3 VAL A2978
THR A2980
ARG A3124
 None
 0.69A 5b2sB-5hu7A:
undetectable		 5b2sB-5hu7A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5hu7 PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		3 / 3 VAL A2978
THR A2980
ARG A3124
 None
 0.73A 5b2tB-5hu7A:
undetectable		 5b2tB-5hu7A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 5hu7 PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		4 / 6 LYS A3111
GLY A3131
SER A3102
LEU A3114
 None
 1.20A 5bphA-5hu7A:
undetectable		 5bphA-5hu7A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 5hu7 PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		4 / 6 LYS A3111
GLY A3131
SER A3102
LEU A3114
 None
 1.10A 5bphD-5hu7A:
undetectable		 5bphD-5hu7A:
24.20